*Clinical Pharmacology, Institute AGATE gGmbH, Pentling, Germany; and

Departments of †Pharmacology & Toxicology, &

‡Psychiatry & Psychotherapy, University of Regensburg, Regensburg, Germany.

Correspondence: Ekkehard Haen, MD, PhD, Klinische Pharmakologie, Institut AGATE gGmbH, Nelkenweg 10, D-93080 Pentling, Germany (e-mail: [email protected]).

E. Haen declares that he is chairman of AGATE e.V, and medical and managing director of Institute AGATE gGmbH, Pentling, Germany, a nongovernmental nonprofit society for pharmacovigilance and pharmacoinformation to improve the benefit-to-risk ratio of drug therapy. He is coeditor of PSIAConline, an internet-based database that yields information on drug–drug interactions. SpringerNature, Heidelberg, Germany runs PSIAC. He is the medical and managing director of InMediCon GmbH, Pentling, Germany, a company focused on creating and marketing internet-based tools for the interpretation and evaluation of drug concentrations and (poly-)pharmacy.

Section coauthors have the same affiliation.