Roles for SGLT2 Inhibitors in Cardiorenal Disease
Abstract
Cardiovascular disease (CVD) and chronic kidney disease (CKD) share common risk factors, including type 2 diabetes mellitus (T2DM). In cardiovascular outcome studies of patients with T2DM, sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy was associated with risk reductions in cardiorenal endpoints. This article aims to provide a comprehensive overview of the efficacy of SGLT2i therapy in patients at risk of cardiorenal disease. A literature review of large outcome studies of patients who had CKD or heart failure with reduced ejection fraction (HFrEF, defined as having a left ventricle ejection fraction [LVEF]
The Author(s). Published by S. Karger AG, Basel
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