Metabolic reprogramming and epigenetic modifications on the path to cancer

Abmayr SM, Workman JL (2019) Histone lysine de-beta-hydroxybutyrylation by SIRT3. Cell Res 29:694–695

PubMed  PubMed Central  Article  Google Scholar 

Adams RR, Maiato H, Earnshaw WC, Carmena M (2001) Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol 153:865–879

CAS  PubMed  PubMed Central  Article  Google Scholar 

Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ (2002) Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes 51:2496–2504

CAS  PubMed  Article  Google Scholar 

Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, Upadhyay P, Uyeminami DL, Pommier A, Kuttner V et al (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361:eaao4227

Alleyn M, Breitzig M, Lockey R, Kolliputi N (2018) The dawn of succinylation: a posttranslational modification. Am J Physiol Cell Physiol 314:C228–C232

PubMed  Article  CAS  Google Scholar 

Allison DF, Wamsley J, Kumar M, Li D, Gray LG, Hart GW, Jones DR, Mayo MW (2012) Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-kappa B acetylation and transcription. Proc Natl Acad Sci USA 109:16888–16893

CAS  PubMed  PubMed Central  Article  Google Scholar 

Altman BJ, Stine ZE, Dang CV (2016) From Krebs to clinic: glutamine metabolism to cancer therapy. Nat Rev Cancer 16:619–634

CAS  PubMed  PubMed Central  Article  Google Scholar 

Alvarez-Nunez F, Bussaglia E, Mauricio D, Ybarra J, Vilar M, Lerma E, de Leiva A, Matias-Guju X, Grp TNS (2006) PTEN promoter methylation in sporadic thyroid carcinomas. Thyroid 16:17–23

CAS  PubMed  Article  Google Scholar 

Amato RJ (2007) Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy. Clin Genitourinary Cancer 5:422–426

CAS  Article  Google Scholar 

Anand R, Marmorstein R (2007) Structure and mechanism of lysine-specific demethylase enzymes. J Biol Chem 282:35425–35429

CAS  PubMed  Article  Google Scholar 

Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS (2003) A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature 423:659–663

CAS  PubMed  Article  Google Scholar 

Ariyannur PS, Moffett JR, Madhavarao CN, Arun P, Vishnu N, Jacobowitz DM, Hallows WC, Denu JM, Namboodiri AMA (2010) Nuclear-cytoplasmic localization of acetyl coenzyme A synthetase-1 in the rat brain. J Comp Neurol 518:2952–2977

CAS  PubMed  PubMed Central  Article  Google Scholar 

Asaga H, Yamada M, Senshu T (1998) Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem Biophys Res Commun 243:641–646

CAS  PubMed  Article  Google Scholar 

Astuti D, Latif F, Dallol A, Dahia PLM, Douglas F, George E, Skoldberg F, Husebye ES, Eng C, Maher ER (2001) Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet 69:49–54

CAS  PubMed  PubMed Central  Article  Google Scholar 

Audia JE, Campbell RM (2016) Histone Modifications and Cancer. Cold Spring Harb Perspect Biol 8:

PubMed  PubMed Central  Article  Google Scholar 

Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM et al (2020) Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science 368:85–89

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ballantyne CM, Davidson MH, Macdougall DE, Bays HE, Dicarlo LA, Rosenberg NL, Margulies J, Newton RS (2013) Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial. J Am Coll Cardiol 62:1154–1162

CAS  PubMed  Article  Google Scholar 

Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH et al (2018) Electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis. Nature 556:501–504

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bandukwala HS, Gagnon J, Togher S, Greenbaum JA, Lamperti ED, Parr NJ, Molesworth AM, Smithers N, Lee K, Witherington J et al (2012) Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci USA 109:14532–14537

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bannister AJ, Kouzarides T (2011) Regulation of chromatin by histone modifications. Cell Res 21:381–395

CAS  PubMed  PubMed Central  Article  Google Scholar 

Barlesi F, Giaccone G, Gallegos-Ruiz MI, Loundou A, Span SW, Lefesvre P, Kruyt FA, Rodriguez JA (2007) Global histone modifications predict prognosis of resected non small-cell lung cancer. J Clin Oncol 25:4358–4364

PubMed  Article  Google Scholar 

Yu WY, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy, D, Yi JN et al (2012) Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun 3

Basappa J, Citir M, Zhang Q, Wang HY, Liu X, Melnikov O, Yahya H, Stein F, Muller R, Traynor-Kaplan A et al (2020) ACLY is the novel signaling target of PIP2/PIP3 and Lyn in acute myeloid leukemia. Heliyon 6:

PubMed  PubMed Central  Article  Google Scholar 

Bayley JP, Kunst HPM, Cascon A, Sampietro ML, Gaal J, Korpershoek E, Hinojar-Gutierrez A, Timmers HJLM, Hoefsloot LH, Hermsen MA et al (2010) SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma. Lancet Oncol 11:366–372

CAS  PubMed  Article  Google Scholar 

Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, van der Mey A, Taschner PEM, Rubinstein WS, Myers EN et al (2000) Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287:848–851

CAS  PubMed  Article  Google Scholar 

Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL (2016) Saccharomyces cerevisiae forms d-2-hydroxyglutarate and couples its degradation to d-lactate formation via a cytosolic transhydrogenase. J Biol Chem 291:6036–6058

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M, Zapatka M, Northcott PA, Sturm D, Wang W et al (2013) Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 24:660–672

CAS  PubMed  Article  Google Scholar 

Berger-Achituv S, Brinkmann V, Abu Abed U, Kuhn LI, Ben-Ezra J, Elhasid R, Zychlinsky A (2013) A proposed role for neutrophil extracellular traps in cancer immunoediting. Front Immunol 4

Bergman Y, Cedar H (2013) DNA methylation dynamics in health and disease. Nat Struct Mol Biol 20:274–281

CAS  PubMed  Article  Google Scholar 

Bharathi SS, Zhang YX, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J et al (2013) Sirtuin 3 (SIRT3) protein regulates long-chain Acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem 288:33837–33847

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu ZC, Zhang L, Czerwonka A, Pawlowska A et al (2020) Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature

Bianco-Miotto T, Chiam K, Buchanan G, Jindal S, Day TK, Thomas M, Pickering MA, O’Loughlin MA, Ryan NK, Raymond WA et al (2010) Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development. Cancer Epidemiol Biomarkers Prev 19:2611–2622

CAS  PubMed  Article  Google Scholar 

Branco AF, Ferreira A, Simoes RF, Magalhaes-Novais S, Zehowski C, Cope E, Silva AM, Pereira D, Sardao VA, Cunha-Oliveira T (2016) Ketogenic diets: from cancer to mitochondrial diseases and beyond. Eur J Clin Invest 46:285–298

PubMed  Article  Google Scholar 

Breillout F, Hadida F, Echinard-Garin P, Lascaux V, Poupon MF (1987) Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet. Anticancer Res 7:861–867

CAS  PubMed  Google Scholar 

Brueckner B, Boy RG, Siedlecki P, Musch T, Kliem HC, Zielenkiewicz P, Suhai S, Wiessler M, Lyko F (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 65:6305–6311

CAS  PubMed  Article  Google Scholar 

Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Voorde JV, Blyth K et al (2017) Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation. Cell Rep 18:647–658

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, Carling D, Thompson CB, Jones RG, Berger SL (2010) Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 329:1201–1205

CAS  PubMed  PubMed Central  Article  Google Scholar 

Caballero F, Fernandez A, Matias N, Martinez L, Fucho R, Elena M, Caballeria J, Morales A, Fernandez-Checa JC, Garcia-Ruiz C (2010) Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem 285:18528–18536

CAS  PubMed  PubMed Central  Article  Google Scholar 

留言 (0)

沒有登入
gif