Clinical Investigations – Research Article

Nobeyama Y.a· Aihara Y.b· Asahina A.a

Author affiliations

aDepartment of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
bAi Dermatology Clinic, Utsunomiya, Japan

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Article / Publication Details

First-Page Preview

Received: January 20, 2022
Accepted: May 01, 2022
Published online: June 07, 2022

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)

For additional information: https://www.karger.com/SAD

Abstract

Introduction: The present study aimed to obtain fundamental data, including climate conditions and Demodex mites, on rosacea and similar diseases in the situation where the wearing of face masks is mandatory due to the coronavirus disease 2019 pandemic. Methods: We enrolled 86 Japanese patients habitually wearing face masks with rosacea and similar diseases. Disease severity was assessed using the Investigator Global Assessment. The presence of Demodex mites was examined microscopically. Treatment involved acaricidal and antibiotic agents. Results: The numbers of male and female patients enrolled were 11 and 75, respectively. Among these patients, 85 (98.8%), 57 (66.3%), and 76 (88.4%) had rosacea, rosacea-like dermatitis (RLD), and demodicosis, respectively. The monthly number of patients with rosacea and demodicosis showed two peaks from May to June and in October, during which monthly mean temperature was approximately 20°C (68°F). Improvement rates in rosacea, RLD, and demodicosis were significantly higher when Demodex mites were no longer detected after treatment. Conclusion: The present results suggest that a season with a mean temperature of approximately 20°C is a risk factor for rosacea and similar diseases in individuals wearing face masks in Japan, and a decrease in Demodex mites is associated with the attenuation of symptoms.

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References van Zuuren EJ. Rosacea. N Engl J Med. 2017 Nov 2;377(18):1754–64. Tan J, Almeida LM, Bewley A, Cribier B, Dlova NC, Gallo R, et al. Updating the diagnosis, classification and assessment of rosacea: recommendations from the global ROSacea COnsensus (ROSCO) panel. Br J Dermatol. 2017 Feb;176(2):431–8. Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R, et al. Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol. 2002 Apr;46(4):584–7. Forton F, De Maertelaer V. Erythematotelangiectatic rosacea may be associated with a subclinical stage of demodicosis: a case-control study. Br J Dermatol. 2019 Oct;181(4):818–25. Forton FMN. The pathogenic role of demodex mites in rosacea: a potential therapeutic target already in erythematotelangiectatic rosacea? Dermatol Ther. 2020 Dec;10(6):1229–53. Tolaymat L, Hall MR. Perioral dermatitis. StatPearls. Treasure Island, FL: StatPearls Publishing; 2020. Teraki Y, Hitomi K, Sato Y, Izaki S. Tacrolimus-induced rosacea-like dermatitis: a clinical analysis of 16 cases associated with tacrolimus ointment application. Dermatology. 2012;224(4):309–14. Tempark T, Shwayder TA. Perioral dermatitis: a review of the condition with special attention to treatment options. Am J Clin Dermatol. 2014 Apr;15(2):101–13. Chiriac AE, Wollina U, Azoicai D. Flare-up of rosacea due to face mask in healthcare workers during COVID-19. Maedica. 2020 Sep;15(3):416–7. Damiani G, Gironi LC, Grada A, Kridin K, Finelli R, Buja A, et al. COVID-19 related masks increase severity of both acne (maskne) and rosacea (mask rosacea): multi-center, real-life, telemedical, and observational prospective study. Dermatol Ther. 2021 Mar;34(2):e14848. Giacalone S, Minuti A, Spigariolo CB, Passoni E, Nazzaro G. Facial dermatoses in the general population due to wearing of personal protective masks during the COVID-19 pandemic: first observations after lockdown. Clin Exp Dermatol. 2021 Mar;46(2):368–9. Webster G, Schaller M, Tan J, Jackson JM, Kerrouche N, Schäfer G. Defining treatment success in rosacea as “clear” may provide multiple patient benefits: results of a pooled analysis. J Dermatolog Treat. 2017 Aug;28(5):469–74. He A, Grandhi R, Kwatra SG. Rosacea and rate of temperature change: examining real-time data from 2004 to 2016. Ann Dermatol. 2018 Dec;30(6):739–41. Chang YS, Huang YC. Role of demodex mite infestation in rosacea: a systematic review and meta-analysis. J Am Acad Dermatol. 2017 Sep;77(3):441–7.e6. Forton FMN, De Maertelaer V. Rosacea and demodicosis: little-known diagnostic signs and symptoms. Acta Derm Venereol. 2019 Jan 1;99(1):47–52. Article / Publication Details

First-Page Preview

Received: January 20, 2022
Accepted: May 01, 2022
Published online: June 07, 2022

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)

For additional information: https://www.karger.com/SAD

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