Keywords

Vascular response

Coronary reactive hyperemia

CYP450-enzymes

Soluble epoxide hydrolase

Adenosine receptors

Plasma/heart perfusate oxylipins

Abbreviations6-keto-PGF1α

6-keto prostaglandin-F1α

A2AAR

A2A adenosine receptor

BK

Large conductance potassium channels

CRH

coronary reactive hyperemia

CYP450-2J2

Cytochrome P450-2J2

DDMS

dibromo-dodecenyl-methylsulfimide

DHETs

dihydroxyeicosatrienoic acids

DiHOMEs

dihydroxyoctadecaenoic acids

EDHF

Endothelium-Derived Hyperpolarizing Factor

EETs

Epoxyeicosatrienoic acids

EpOMEs

epoxyoctadecaenoic acids

HETEs

hydroxyeicosatetraenoic acids

HODEs

hydroxyoctadecadienoic acids

KATP

ATP-sensitive K+ channels

KCa

Calcium-acitvated K+ channels

LC-MS/MS

liquid chromatography tandem mass spectroscopy

PUFAs

polyunsaturated fatty acids

sEH

soluble epoxide hydrolase

sEH−/− or Ephx2−/−

sEH–knockout mice

sEH+/+

wild type mice normally expressing sEH

t-AUCB

trans-4-[4-(3-adamantan-1-ylureido)cyclohexyloxy] benzoic acid

A2AAR−/−

A2AAR–knockout mice

A2AAR+/+

wild type mice normally expressing A2AAR

A1AR

A1 adenosine receptor

A1AR−/−

A1AR–knockout mice

A1AR+/+

wild type mice normally expressing A1AR

A2BAR

A2B adenosine receptor

A2BAR−/−

A2BAR–knockout mice

A2BAR+/+

wild type mice normally expressing A2BAR

CVDs

Cardiovascular diseases

CAD

coronary artery disease

ADORA1

adenosine A1 receptor gene

ADORA2

adenosine A2A receptor gene

Tie2-sEH Tr mice

sEH-overexpressed mice

Tie2-CYP2J2 Tr mice

CYP2J2-overexpressed mice

A3AR

adenosine A3 receptor

PPARγ

peroxisome proliferator-activated receptor gamma

PPARα

peroxisome proliferator-activated receptor alpha

SSI or acute ischemic preconditioning

sublethal simulated ischemia

A1AR-tgm

over-expression of adenosine A1 receptor in transgenic mice

DPCPX

8-Cyclopentyl-1,3-dipropylxanthine

SHR

spontaneously hypertensive rats

RAAS

renin-angiotensin-aldosterone system

iPAH

idiopathic pulmonary arterial hypertension

PAH

pulmonary arterial hypertension

GPCR

G-protein-coupled receptor

MSPPOH

N-methylsulphonyl-6-(2-proparglyloxyphenyl) hexamide

14,15-EEZE

14,15-Epoxyeicosa-5(Z)-enoic Acid

HET0016

N-hydroxy-N_-(4-n-butyl-2-methylphenyl) formamidine

AR9281

[1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea

AUDA

12-(3-adamantane-1-yl-ureido) dodecanoic acid

BI00611953

N-(2-chloro-4-methanesulfonyl-benzyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

CDU/NCND

1-cyclohexyl-3-dodecyl-urea

TPPU

N-[1-(1-oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl)-urea

AEPU

1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl) urea

DCU

N,N′-dicyclohexylurea

GSK2256294

((1R,3S)-N-(4-cyano-2-(trifluoromethyl)benzyl)-3- ((4-methyl-6-(methylamino)-1,3,5-triazin-2- yl)amino)cyclohexane-1-carboxamide)

GSK2188931B

[N-(methyl)- 1-[4-methyl-6 (methylamino-1,3,5-triazin-2-yl]- 4-piperidinecarboxamide]

PTUPB

[4-(5-phenyl-3--pyrazol-1-yl)-benzenesulfonamide]

t-CUPM

[trans-5--pyridine-2 carboxylic acid methylamide

TPAU

1-trifluoromethoxyphenyl-3-(1-acetylpiperidin-4-yl) urea

TUPS

1-(1-methanesulfonyl-piperidin-4-yl)-3- (4-trifluoromethoxy-phenyl)-urea

8-HUDE

12-(3-hexylureido) dodec-8-enoic acid

NECA

5’-N-Ethylcarboxamidoadenosine

CGS-21680

2-(4-(2-Carboxyethyl)phenethylamino)-5’-N-ethylcarboxamidoadenosine

CCPA

2-Chloro-N6-cyclopentyladenosine

ZM241385

4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol

SCH-58261

2-(2-furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

Chelerythrine chloride

1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

Glibenclamide

5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl) phenyl]ethyl]-2-methoxybenzamide

5-hydroxydecanoate

5-hydroxydecanoic acid sodium salt

Rosiglitazone

5-(4-methyl)-1,3-thiazolidine-2,4-dione

GW7647

2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoic acid

eNOS−/− mice

endothelial nitric oxide synthase knockout mice.