Novel Insights from Clinical Practice
Duplaine A. · Cogrel O.Department of Dermatology, Hôpital Saint-André, CHU de Bordeaux, Bordeaux, France
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Article / Publication DetailsFirst-Page Preview
Received: January 09, 2022
Accepted: March 12, 2022
Published online: April 27, 2022
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1
ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)
For additional information: https://www.karger.com/SAD
AbstractIntroduction: Recent expert recommendations suggest mycophenolate mofetil (MMF) as a third-line therapy, in severe corticosteroid-dependent or corticosteroid-resistant nail lichen planus (NLP). However, there is currently no literature to support MMF use in this indication. This is a retrospective monocentric French case series of 5 patients with severe corticodependant or corticoresistant NLP treated by oral MMF (2–3 g/day), between 2013 and 2021. Case Presentation: The primary outcome was therapeutic success in a target fingernail. All 5 patients showed some clinical improvement, ranging from mild improvement (1/5) to clinical cure (2/5). Clinical improvement was more significant when the drug was taken for a longer period (24 months vs. 4 months) and at a higher dose (3 g/day vs. 2 g/day). Relapse occurred after stopping or tapering the MMF dose. MMF was well tolerated. Discussion/Conclusion: MMF may be a treatment to consider for severe corticosteroid-dependent or corticosteroid-resistant NLP. The long-term safety of this treatment warrants further investigation.
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References Le Cleach L, Chosidow O. Clinical practice. Lichen planus. N Engl J Med. 2012;366:723–32. Hrin ML, Bashyam AM, Huang WW, Feldman SR. Mycophenolate mofetil for the treatment of cutaneous lichen planus: a retrospective case series. J Am Acad Dermatol. 2021 Apr;84(4):1091–4. Frieling U, Bonsmann G, Schwarz T, Luger TA, Beissert S. Treatment of severe lichen planus with mycophenolate mofetil. J Am Acad Dermatol. 2003;49:1063–6. Iorizzo M, Tosti A, Starace M, Baran R, Daniel CR 3rd, Di Chiacchio N, et al. Isolated nail lichen planus: an expert consensus on treatment of the classical form. J Am Acad Dermatol. 2020;83(6):1717–23. Page S, Tait CP. Mycophenolic acid in dermatology a century after its discovery. Australas J Dermatol. 2015;56(1):77–83. Phan K, Smith SD. Mycophenolate mofetil and atopic dermatitis: systematic review and meta-analysis. J Dermatolog Treat. 2020;31:810–4. Article / Publication DetailsFirst-Page Preview
Received: January 09, 2022
Accepted: March 12, 2022
Published online: April 27, 2022
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1
ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)
For additional information: https://www.karger.com/SAD
Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
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