Aamodt KI, Powers AC (2017) Signals in the pancreatic islet microenvironment influence beta-cell proliferation. Diabetes Obes Metab 19(Suppl 1):124–136
CAS PubMed PubMed Central Google Scholar
Aguayo-Mazzucato C, Bonner-Weir S (2018) Pancreatic beta cell regeneration as a possible therapy for diabetes. Cell Metab 27:57–67
Agulnick AD, Ambruzs DM, Moorman MA, Bhoumik A, Cesario RM, Payne JK, Kelly JR, Haakmeester C, Srijemac R, Wilson AZ et al (2015) Insulin-producing endocrine cells differentiated in vitro from human embryonic stem cells function in macroencapsulation devices in vivo. Stem Cells Transl Med 4:1214–1222
CAS PubMed PubMed Central Google Scholar
Ahren B (2000) Autonomic regulation of islet hormone secretion–implications for health and disease. Diabetologia 43:393–410
Alvarez-Dominguez JR, Donaghey J, Rasouli N, Kenty JHR, Helman A, Charlton J, Straubhaar JR, Meissner A, Melton DA (2020) Circadian entrainment triggers maturation of human in vitro islets. Cell Stem Cell 26(108–122):e110
Ameri J, Borup R, Prawiro C, Ramond C, Schachter KA, Scharfmann R, Semb H (2017) Efficient generation of glucose-responsive beta cells from isolated GP2(+) human pancreatic progenitors. Cell Rep 19:36–49
Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, Khalaj M, Crespo M, Perera M, Xiang JZ et al (2018) Discovery of a drug candidate for GLIS3-associated diabetes. Nat Commun 9:2681
PubMed PubMed Central Google Scholar
Arrojo e Drigo R, Ali Y, Diez J, Srinivasan DK, Berggren PO, Boehm BO (2015) New insights into the architecture of the islet of Langerhans: a focused cross-species assessment. Diabetologia 58:2218–2228
Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T et al (2015) Paternal allelic mutation at the Kcnq1 locus reduces pancreatic beta-cell mass by epigenetic modification of Cdkn1c. Proc Natl Acad Sci USA 112:8332–8337
CAS PubMed PubMed Central Google Scholar
Ashcroft FM, Rorsman P (2012) Diabetes mellitus and the beta cell: the last ten years. Cell 148:1160–1171
CAS PubMed PubMed Central Google Scholar
Augsornworawat P, Maxwell KG, Velazco-Cruz L, Millman JR (2020) Single-cell transcriptome profiling reveals beta cell maturation in stem cell-derived islets after transplantation. Cell Rep 32:108067
CAS PubMed PubMed Central Google Scholar
Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J et al (2016) Identification of proliferative and mature beta-cells in the islets of Langerhans. Nature 535:430–434
Bakhti M, Scheibner K, Tritschler S, Bastidas-Ponce A, Tarquis-Medina M, Theis FJ, Lickert H (2019) Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro. Mol Metab 30:16–29
CAS PubMed PubMed Central Google Scholar
Balboa D, Saarimaki-Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, Eurola S, Ustinov J, Grym H, Huopio H et al (2018) Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. Elife 7
Basford CL, Prentice KJ, Hardy AB, Sarangi F, Micallef SJ, Li X, Guo Q, Elefanty AG, Stanley EG, Keller G et al (2012) The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells. Diabetologia 55:358–371
Bi H, Ye K, Jin S (2020) Proteomic analysis of decellularized pancreatic matrix identifies collagen V as a critical regulator for islet organogenesis from human pluripotent stem cells. Biomaterials 233:119673
Bishay RH, Greenfield JR (2016) A review of maturity onset diabetes of the young (MODY) and challenges in the management of glucokinase-MODY. Med J Aust 205:480–485
Borden P, Houtz J, Leach SD, Kuruvilla R (2013) Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. Cell Rep 4:287–301
CAS PubMed PubMed Central Google Scholar
Bornstein SR, Rubino F, Khunti K, Mingrone G, Hopkins D, Birkenfeld AL, Boehm B, Amiel S, Holt RIG, Skyler JS et al (2020) Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol 8:546–550
CAS PubMed PubMed Central Google Scholar
Brissova M, Fowler MJ, Nicholson WE, Chu A, Hirshberg B, Harlan DM, Powers AC (2005) Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy. J Histochem Cytochem 53:1087–1097
Broda TR, McCracken KW, Wells JM (2019) Generation of human antral and fundic gastric organoids from pluripotent stem cells. Nat Protoc 14:28–50
CAS PubMed PubMed Central Google Scholar
Bruin JE, Erener S, Vela J, Hu X, Johnson JD, Kurata HT, Lynn FC, Piret JM, Asadi A, Rezania A et al (2014) Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells. Stem Cell Res 12:194–208
Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggrern PO, Caicedo A (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 103:2334–2339
CAS PubMed PubMed Central Google Scholar
Cai EP, Ishikawa Y, Zhang W, Leite NC, Li J, Hou S, Kiaf B, Hollister-Lock J, Yilmaz NK, Schiffer CA et al (2020) Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes. Nat Metab 2:934–945
CAS PubMed PubMed Central Google Scholar
Candiello J, Grandhi TSP, Goh SK, Vaidya V, Lemmon-Kishi M, Eliato KR, Ros R, Kumta PN, Rege K, Banerjee I (2018) 3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform. Biomaterials 177:27–39
Cardenas-Diaz FL, Osorio-Quintero C, Diaz-Miranda MA, Kishore S, Leavens K, Jobaliya C, Stanescu D, Ortiz-Gonzalez X, Yoon C, Chen CS et al (2019) Modeling monogenic diabetes using human ESCs reveals developmental and metabolic deficiencies caused by mutations in HNF1A. Cell Stem Cell 25(273–289):e275
Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R et al (2014) De novo formation of insulin-producing “neo-beta cell islets” from intestinal crypts. Cell Rep 6:1046–1058
CAS PubMed PubMed Central Google Scholar
Choi KM, Seo YK, Yoon HH, Song KY, Kwon SY, Lee HS, Park JK (2008) Effect of ascorbic acid on bone marrow-derived mesenchymal stem cell proliferation and differentiation. J Biosci Bioeng 105:586–594
Clevers H (2016) Modeling development and disease with organoids. Cell 165:1586–1597
Coate KC, Cha J, Shrestha S, Wang W, Goncalves LM, Almaca J, Kapp ME, Fasolino M, Morgan A, Dai C et al (2020) SARS-CoV-2 cell entry factors ACE2 and TMPRSS2 are expressed in the microvasculature and ducts of human pancreas but are not enriched in beta cells. Cell Metab 32(1028–1040):e1024
Cogger KF, Sinha A, Sarangi F, McGaugh EC, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke JL, Screaton RA et al (2017) Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors. Nat Commun 8:331
PubMed PubMed Central Google Scholar
Cooper-Jones B, Ford C (2016) Islet cell replacement therapy for insulin-dependent diabetes. In: CADTH Issues in Emerging Health Technologies (Ottawa (ON)), pp 1–9
D’Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24:1392–1401
Davis JC, Alves TC, Helman A, Chen JC, Kenty JH, Cardone RL, Liu DR, Kibbey RG, Melton DA (2020) Glucose response by stem cell-derived beta cells in vitro is inhibited by a bottleneck in glycolysis. Cell Rep 31:107623
CAS PubMed PubMed Central Google Scholar
de Vargas LM, Sobolewski J, Siegel R, Moss LG (1997) Individual beta cells within the intact islet differentially respond to glucose. J Biol Chem 272:26573–26577
Dominguez-Bendala J, Qadir MMF, Pastori RL (2019) Pancreatic progenitors: there and back again. Trends Endocrinol Metab 30:4–11
Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41–46
Dutta D, Heo I, Clevers H (2017) Disease modeling in stem cell-derived 3D organoid systems. Trends Mol Med 23:393–410
Dwivedi OP, Lehtovirta M, Hastoy B, Chandra V, Krentz NAJ, Kleiner S, Jain D, Richard AM, Abaitua F, Beer NL et al (2019) Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. Nat Genet 51:1596–1606
CAS PubMed PubMed Central Google Scholar
Eberhard D, Kragl M, Lammert E (2010) ‘Giving and taking’: endothelial and beta-cells in the islets of Langerhans. Trends Endocrinol Metab 21:457–463
Fatehullah A, Tan SH, Barker N (2016) Organoids as an in vitro model of human development and disease. Nat Cell Biol 18:246–254
Ghazizadeh Z, Kao DI, Amin S, Cook B, Rao S, Zhou T, Zhang T, Xiang Z, Kenyon R, Kaymakcalan O et al (2017) ROCKII inhibition promotes the maturation of human pancreatic beta-like cells. Nat Commun 8:298
PubMed PubMed Central Google Scholar
Giobbe GG, Crowley C, Luni C, Campinoti S, Khedr M, Kretzschmar K, De Santis MM, Zambaiti E, Michielin F, Meran L et al (2019) Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture. Nat Commun 10:5658
PubMed PubMed Central Google Scholar
Gouzi M, Kim YH, Katsumoto K, Johansson K, Grapin-Botton A (2011) Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development. Dev Dyn 240:589–604
Greggio C, De Franceschi F, Figueiredo-Larsen M, Gobaa S, Ranga A, Semb H, Lutolf M, Grapin-Botton A (2013) Artificial three-dimensional niches deconstruct pancreas development in vitro. Development 140:4452–4462
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