M. Trimarchi1, D. Lauritano2, G. Ronconi3, A. Caraffa4, C.E. Gallenga5, I. Frydas6 and S.K. Kritas7

Author information

1Department of Medicine and Surgery, Centre of Neuroscience of Milan, University of Milan, Italy;
2Medicine and Surgery Centre of Neuroscience of Milan, University of Milan-Bicocca, Milano, Italy;
3Clinica dei Pazienti del Territorio, Fondazione Policlinico Gemelli, Rome, Italy;
4School of Pharmacy, University of Camerino, Camerino, Italy;
5Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, Ferrara, Italy;
6Aristotelian University, Thessaloniki, Greece;
7Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece

Abstract

Mast cells (MCs) are ubiquitous immune cells that participate in allergic reactions through the activation of the FCeRI receptor, but also in inflammatory processes induced by various biological and non-biological compounds, neurotransmitters, and cytokines. Activation of MCs can lead to the immediate release of chemical mediators of inflammation, but it can also result in the secretion of pro-inflammatory cytokines without degranulation. In the inflammatory network, macrophages cross-talk with MCs by producing IL-1, which stimulates MCs to secrete pro-inflammatory cytokines including IL-6, TNF, IL-33 and other cytokines and chemokines. IL-37 and IL-38 are anti-inflammatory cytokines implicated in the suppression of the immune and inflammatory system. Therefore, it is pertinent to think that these cytokines can open new pathways in the field of inflammatory and immune diseases. Here we report the relationships between macrophage cytokines, MCs, and inflammation.

Keywords:

mast cell, inflammation, cytokine, macrophage, anti-inflammatory

Publication type

Editorial

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