Acknowledgments. The authors acknowledge Chad Rogers, Stephen Patek, Colin Steele, Patrick Keith-Hynes, Antoine Robert, Benton Mize, and Laurie Wright from TypeZero Technologies for their provision of the DSS, unwavering technical support, and commitment to see this study through.

Funding. This work was supported by grants from the National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases (R01DK051562 and DP3DK101055), and material support was provided by Dexcom, Novo Nordisk, and TypeZero Technologies.

Duality of Interest. S.A. receives research support from Medtronic (paid to institution). G.O., S.O., and C.Levi. receive research support from Tandem Diabetes Care, Insulet, Dexcom, and Abbott Laboratories (paid to institution). L.E. has received consulting fees from Tandem Diabetes Care and Ypsomed. D.W.L. receives research support from Tandem Diabetes Care and Insulet (paid to institution). C. Levy receives research support from Tandem Diabetes Care, Insulet, Dexcom, and Abbott Laboratories (paid to institution) and has served as a consultant for Dexcom and Eli Lilly. B.B. has received research support from Tandem Diabetes Care, Insulet, Dexcom, JDRF, the National Institutes of Health, and the Helmsely Foundation (paid to institution) and served as a consultant for Novo Nordisk, Medtronic Diabetes, ConvaTec, Dexcom, Insulet, and Tandem Diabetes Care. No other potential conflicts of interest relevant to this article were reported.

Author Contributions. A.B. participated in data analysis and manuscript writing and editing. S.A. was the principal investigator (PI) at the University of Virginia (UVA) and participated in study design, contributed to manuscript writing and revisions, led participant enrollment, and monitored site safety and assumes responsibility and accountability for UVA site data. L.N., G.O., and J.R. participated in study enrollment, conducted study visits, and contributed to manuscript revisions. S.O. participated in study enrollment, conducted study visits, performed study device and data management, and contributed to manuscript edits. L.H., C.Levi., and L.E. participated in study enrollment, conducted study visits, and contributed to manuscript revisions. D.W.L. participated in study enrollment and contributed to manuscript revisions. C. Levy was the PI at the Icahn School of Medicine and contributed to manuscript writing and revisions, led participant enrollment, and monitored site safety and assumes responsibility and accountability for Icahn School of Medicine site data. B.B. was the PI at Stanford and contributed to manuscript writing and revisions, led participant enrollment, and monitored site safety and assumes responsibility and accountability for Stanford site data. M.D.B. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.