Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303–10.

CAS  PubMed  Google Scholar 

Moore LJ, Moore FA, Todd SR, Jones SL, Turner KL, Bass BL. Sepsis in general surgery: the 2005–2007 national surgical quality improvement program perspective. Arch Surg Chic Ill. 1960;2010(145):695–700.

Google Scholar 

Liu V, Escobar GJ, Greene JD, Soule J, Whippy A, Angus DC, et al. Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA Am Med Assoc. 2014;312:90–2.

CAS  Google Scholar 

Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, et al. Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009–2014. JAMA Am Med Assoc. 2017;318:1241–9.

Google Scholar 

Arefian H, Heublein S, Scherag A, Brunkhorst FM, Younis MZ, Moerer O, et al. Hospital-related cost of sepsis: a systematic review. J Infect. 2017;74:107–17.

PubMed  Google Scholar 

Álvaro-Meca A, Jiménez-Sousa MA, Micheloud D, Sánchez-Lopez A, Heredia-Rodríguez M, Tamayo E, et al. Epidemiological trends of sepsis in the twenty-first century (2000–2013): an analysis of incidence, mortality, and associated costs in Spain. Popul Health Metr. 2018;16:4.

PubMed  PubMed Central  Google Scholar 

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47:1181–247.

Google Scholar 

Vincent J-L, De Backer D. Circulatory shock. N Engl J Med. 2013;369:1726–34.

CAS  PubMed  Google Scholar 

Teng T-S, Ji A-L, Ji X-Y, Li Y-Z. Neutrophils and immunity: from bactericidal action to being conquered. J Immunol Res. 2017;2017:9671604.

PubMed  PubMed Central  Google Scholar 

Babior BM. Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med. 1978;298:659–68.

CAS  PubMed  Google Scholar 

Greif R, Akça O, Horn EP, Kurz A, Sessler DI. Outcomes research group. Supplemental perioperative oxygen to reduce the incidence of surgical-wound infection. N Engl J Med. 2000;342:161–7.

CAS  PubMed  Google Scholar 

Brasel K, McRitchie D, Dellinger P, EBRS Group. Canadian Association of General Surgeons and American College of Surgeons Evidence Based Reviews in Surgery. 21: the risk of surgical site infection is reduced with perioperative oxygen. Can J Surg J Can Chir. 2007;50:214–6.

Belda FJ, Aguilera L, de la Asunción JG, Alberti J, Vicente R, Ferrándiz L, et al. Supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial. JAMA. 2005;294:2035–42.

CAS  PubMed  Google Scholar 

Stolmeijer R, ter Maaten JC, Zijlstra JG, Ligtenberg JJM. Oxygen therapy for sepsis patients in the emergency department: a little less? Eur J Emerg Med. 2014;21:233–5.

PubMed  Google Scholar 

Popoff B, Besnier E, Dureuil B, Veber B, Clavier T. Effect of early hyperoxemia on mortality in mechanically ventilated septic shock patients according to Sepsis-3 criteria: analysis of the MIMIC-III database. Eur J Emerg Med. 2021;28:469–75.

PubMed  Google Scholar 

Asfar P, Schortgen F, Boisramé-Helms J, Charpentier J, Guérot E, Megarbane B, et al. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial. Lancet Respir Med. 2017;5:180–90.

CAS  PubMed  Google Scholar 

Young P, Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, et al. Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX). Intensive Care Med. 2020;46:17–26.

CAS  PubMed  Google Scholar 

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315:801–10.

CAS  PubMed  PubMed Central  Google Scholar 

Madotto F, Rezoagli E, Pham T, Schmidt M, McNicholas B, Protti A, et al. Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study. Crit Care. 2020;24:125.

PubMed  PubMed Central  Google Scholar 

Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European society of intensive care medicine. Intensive Care Med. 1996;22:707–10.

CAS  PubMed  Google Scholar 

Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–29.

CAS  PubMed  PubMed Central  Google Scholar 

CDC/NHSN surveillance definitions for specific types of infections. 2021;30.

Helmerhorst HJF, Roos-Blom M-J, van Westerloo DJ, Abu-Hanna A, de Keizer NF, de Jonge E. Associations of arterial carbon dioxide and arterial oxygen concentrations with hospital mortality after resuscitation from cardiac arrest. Crit Care Lond Engl. 2015;19:348.

Google Scholar 

Flower L, Martin D. Management of hypoxaemia in the critically ill patient. Br J Hosp Med Lond Engl. 2005;2020(81):1–10.

Google Scholar 

SRLF Trial Group. Hypoxemia in the ICU: prevalence, treatment, and outcome. Ann Intensive Care. 2018;8:82.

Google Scholar 

Aggarwal NR, Brower RG, Hager DN, Thompson BT, Netzer G, Shanholtz C, et al. Oxygen exposure resulting in arterial oxygen tensions above the protocol goal was associated with worse clinical outcomes in acute respiratory distress syndrome. Crit Care Med. 2018;46:517–24.

CAS  PubMed  PubMed Central  Google Scholar 

de Jonge E, Peelen L, Keijzers PJ, Joore H, de Lange D, van der Voort PHJ, et al. Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care Lond Engl. 2008;12:R156.

Google Scholar 

Chu DK, Kim LH-Y, Young PJ, Zamiri N, Almenawer SA, Jaeschke R, et al. Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis. Lancet Lond Engl. 2018;391:1693–705.

Google Scholar 

Girardis M, Alhazzani W, Rasmussen BS. What’s new in oxygen therapy? Intensive Care Med. 2019;45:1009–11.

PubMed  Google Scholar 

Siemieniuk RAC, Chu DK, Kim LH-Y, Güell-Rous M-R, Alhazzani W, Soccal PM, et al. Oxygen therapy for acutely ill medical patients: a clinical practice guideline. BMJ. 2018;363:K4169.

PubMed  Google Scholar 

Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, et al. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA. 2010;303:2165–71.

CAS  PubMed  Google Scholar 

Elmer J, Scutella M, Pullalarevu R, Wang B, Vaghasia N, Trzeciak S, et al. The association between hyperoxia and patient outcomes after cardiac arrest: analysis of a high-resolution database. Intensive Care Med. 2015;41:49–57.

PubMed  Google Scholar 

Janz DR, Hollenbeck RD, Pollock JS, McPherson JA, Rice TW. Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest. Crit Care Med. 2012;40:3135–9.

CAS  PubMed  PubMed Central  Google Scholar 

Ni Y-N, Wang Y-M, Liang B-M, Liang Z-A. The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis. BMC Pulm Med. 2019;19:53.

PubMed  PubMed Central  Google Scholar 

Rincon F, Kang J, Maltenfort M, Vibbert M, Urtecho J, Athar MK, et al. Association between hyperoxia and mortality after stroke: a multicenter cohort study. Crit Care Med. 2014;42:387–96.

PubMed  Google Scholar 

Davis DP, Meade W, Sise MJ, Kennedy F, Simon F, Tominaga G, et al. Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma. 2009;26:2217–23.

PubMed  Google Scholar 

Rincon F, Kang J, Vibbert M, Urtecho J, Athar MK, Jallo J. Significance of arterial hyperoxia and relationship with case fatality in traumatic brain injury: a multicentre cohort study. J Neurol Neurosurg Psychiatry. 2014;85:799–805.

PubMed  Google Scholar 

Asher SR, Curry P, Sharma D, Wang J, O’Keefe GE, Daniel-Johnson J, et al. Survival advantage and PaO2 threshold in severe traumatic brain injury. J Neurosurg Anesthesiol. 2013;25:168–73.

PubMed  Google Scholar 

Helmerhorst HJF, Roos-Blom M-J, van Westerloo DJ, de Jonge E. Association between arterial hyperoxia and outcome in subsets of critical illness: a systematic review, meta-analysis, and meta-regression of cohort studies. Crit Care Med. 2015;43:1508–19.

PubMed  Google Scholar 

Vaahersalo J, Bendel S, Reinikainen M, Kurola J, Tiainen M, Raj R, et al. Arterial blood gas tensions after resuscitation from out-of-hospital cardiac arrest: associations with long-term neurologic outcome. Crit Care Med. 2014;42:1463–70.

PubMed  Google Scholar 

Jakkula P, Reinikainen M, Hästbacka J, Loisa P, Tiainen M, Pettilä V, et al. Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial. Intensive Care Med. 2018;44:2112–21.

CAS  PubMed  PubMed Central  Google Scholar 

Wihersaari L, Ashton NJ, Reinikainen M, Jakkula P, Pettilä V, Hästbacka J, et al. Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial. Intensive Care Med. 2021;47:39–48.

PubMed  Google Scholar 

Martin J, Mazer-Amirshahi M, Pourmand A. The impact of hyperoxia in the critically ill patient: a review of the literature. Respir Care. 2020;65:1202–10.

PubMed  Google Scholar 

Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA. 2016;316:1583–9.

CAS  PubMed  Google Scholar 

ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, Mackle D, Bellomo R, Bailey M, Beasley R, Deane A, et al. Conservative Oxygen Therapy during Mechanical Ventilation in the ICU. N Engl J Med. 2020;382:989–98.

Panwar R, Hardie M, Bellomo R, Barrot L, Eastwood GM, Young PJ, et al. Conservative versus liberal oxygenation targets for mechanically ventilated patients. A pilot multicenter randomized controlled trial. Am J Respir Crit Care Med. 2016;193:43–51.

CAS  PubMed  Google Scholar 

Barrot L, Asfar P, Mauny F, Winiszewski H, Montini F, Badie J, et al. Liberal or conservative oxygen therapy for acute respiratory distress syndrome. N Engl J Med. 2020;382:999–1008.

CAS  PubMed  Google Scholar 

Gelissen H, de Grooth H-J, Smulders Y, Wils E-J, de Ruijter W, Vink R, et al. Effect of low-normal vs high-normal oxygenation targets on organ dysfunction in critically ill patients: a randomized clinical trial. JAMA. 2021;326:940–8.

CAS  PubMed