The effects of psilocybin on cognitive and emotional functions in healthy participants: Results from a phase 1, randomised, placebo-controlled trial involving simultaneous psilocybin administration and preparation

Anderson, BT, Danforth, A, Daroff, R, et al. (2020) Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: An open-label safety and feasibility pilot study. EClinicalMedicine 27: 100538.
Google Scholar | Crossref | Medline Arioli, M, Crespi, C, Canessa, N (2018) Social cognition through the lens of cognitive and clinical neuroscience. BioMed Research International 2018: 4283427.
Google Scholar | Crossref | Medline Baron-Cohen, S, Wheelwright, S, Hill, J, et al. (2001) The ‘Reading the Mind in the Eyes’ Test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry 42(2): 241–251.
Google Scholar | Crossref | Medline | ISI Bernasconi, F, Schmidt, A, Pokorny, T, et al. (2014) Spatiotemporal brain dynamics of emotional face processing modulations induced by the serotonin 1A/2A receptor agonist psilocybin. Cerebral Cortex 24(12): 3221–3231.
Google Scholar | Crossref | Medline Bogenschutz, MP, Forcehimes, AA, Pommy, JA, et al. (2015) Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study. Journal of Psychopharmacology 29(3): 289–299.
Google Scholar | SAGE Journals | ISI Carhart-Harris, RL, Goodwin, GM (2017) The therapeutic potential of psychedelic drugs: Past, present, and future. Neuropsychopharmacology 42(11): 2105–2113.
Google Scholar | Crossref | Medline Carhart-Harris, RL, Bolstridge, M, Day, CMJ, et al. (2018) Psilocybin with psychological support for treatment-resistant depression: Six-month follow-up. Psychopharmacology 235(2): 399–408.
Google Scholar | Crossref | Medline Carhart-Harris, RL, Bolstridge, M, Rucker, J, et al. (2016) Psilocybin with psychological support for treatment-resistant depression: An open-label feasibility study. Lancet Psychiatry 3(7): 619–627.
Google Scholar | Crossref | Medline Carhart-Harris, RL, Erritzoe, D, Williams, T, et al. (2012) Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences of the United States of America 109(6): 2138–2143.
Google Scholar | Crossref | Medline | ISI Ciranna, L (2006) Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: Implications in physiological functions and in pathology. Current Neuropharmacology 4(2): 101–114.
Google Scholar | Crossref | Medline Clarke, Z (2007) Psilocybin. In: Enna, SJ, Bylund, DB (eds) xPharm: The Comprehensive Pharmacology Reference. New York: Elsevier, pp.1–4.
Google Scholar | Crossref Coric, V, Stock, EG, Pultz, J, et al. (2009) Sheehan Suicidality Tracking Scale (Sheehan-STS): Preliminary results from a multicenter clinical trial in generalized anxiety disorder. Psychiatry 6(1): 26–31.
Google Scholar | Medline Cotter, J, Granger, K, Backx, R, et al. (2018) Social cognitive dysfunction as a clinical marker: A systematic review of meta-analyses across 30 clinical conditions. Neuroscience & Biobehavioral Reviews 84: 92–99.
Google Scholar | Crossref | Medline Crockett, MJ, Clark, L, Hauser, MD, et al. (2010) Serotonin selectively influences moral judgment and behavior through effects on harm aversion. Proceedings of the National Academy of Sciences of the United States of America 107(40): 17433–17438.
Google Scholar | Crossref | Medline Davis, AK, Barrett, FS, May, DG, et al. (2021) Effects of psilocybin-assisted therapy on major depressive disorder: A randomized clinical trial. JAMA Psychiatry 78: 481–489.
Google Scholar | Crossref | Medline Dos Santos, RG, Bouso, JC, Hallak, JEC (2017) Ayahuasca, dimethyltryptamine, and psychosis: A systematic review of human studies. Therapeutic Advances in Psychopharmacology 7(4): 141–157.
Google Scholar | SAGE Journals | ISI Gabay, A, Carhart-Harris, RL, Mazibuko, N, et al. (2018) Psilocybin and MDMA reduce costly punishment in the Ultimatum Game. Scientific Reports 8(1): 8236.
Google Scholar | Crossref | Medline Gough, HG, McClosky, H, Meehl, PE (1952) A personality scale for social responsibility. Journal of Abnormal and Social Psychology 47(1): 73–80.
Google Scholar | Crossref | Medline | ISI Griffiths, R, Richards, W, Johnson, M, et al. (2008) Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. Journal of Psychopharmacology 22(6): 621–632.
Google Scholar | SAGE Journals | ISI Griffiths, RR, Johnson, MW, Carducci, MA, et al. (2016) Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology 30(12): 1181–1197.
Google Scholar | SAGE Journals | ISI Griffiths, RR, Johnson, MW, Richards, WA, et al. (2011) Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects. Psychopharmacology 218(4): 649–665.
Google Scholar | Crossref | Medline | ISI Grob, CS, Danforth, AL, Chopra, GS, et al. (2011) Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Archives of General Psychiatry 68(1): 71–78.
Google Scholar | Crossref | Medline Halberstadt, AL, Geyer, MA (2011) Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens. Neuropharmacology 61(3): 364–381.
Google Scholar | Crossref | Medline Harman, WW, McKim, RH, Mogar, RE, et al. (1966) Psychedelic agents in creative problem-solving: A pilot study. Psychological Reports 19(1): 211–227.
Google Scholar | SAGE Journals | ISI Harmer, CJ, Shelley, NC, Cowen, PJ, et al. (2004) Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. American Journal of Psychiatry 161(7): 1256–1263.
Google Scholar | Crossref | Medline Hasler, F, Grimberg, U, Benz, MA, et al. (2004) Acute psychological and physiological effects of psilocybin in healthy humans: A double-blind, placebo-controlled dose-effect study. Psychopharmacology 172(2): 145–156.
Google Scholar | Crossref | Medline Hendin, HM, Penn, AD (2021) An episode of mania following self-reported ingestion of psilocybin mushrooms in a woman previously not diagnosed with bipolar disorder: A case report. Bipolar Disorders 23: 733–735.
Google Scholar | Crossref | Medline Hill, SL, Thomas, SH (2020) Drug misuse. Medicine 48(3): 176–181.
Google Scholar | Crossref Hofmann, A, Heim, R, Brack, A, et al. (1958) Psilocybin, a psychotropic substance from the Mexican mushroom Psilicybe Mexicana Heim. Experientia 14(3): 107–109.
Google Scholar | Crossref | Medline Hofmann, A, Heim, R, Brack, A, et al. (1959) Psilocybin und Psilocin, zwei psychotrope Wirkstoffe aus mexikanischen Rauschpilzen. Helvetica Chimica Acta 42(5): 1557–1572.
Google Scholar | Crossref Johnson, MW, Garcia-Romeu, A, Cosimano, MP, et al. (2014) Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. Journal of Psychopharmacology 28(11): 983–992.
Google Scholar | SAGE Journals | ISI Jones, DE, Greenberg, M, Crowley, M (2015) Early social-emotional functioning and public health: The relationship between kindergarten social competence and future wellness. American Journal of Public Health 105(11): 2283–2290.
Google Scholar | Crossref | Medline | ISI Kometer, M, Schmidt, A, Bachmann, R, et al. (2012) Psilocybin biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic subreceptors. Biological Psychiatry 72(11): 898–906.
Google Scholar | Crossref | Medline Kraehenmann, R, Preller, KH, Scheidegger, M, et al. (2015) Psilocybin-induced decrease in amygdala reactivity correlates with enhanced positive mood in healthy volunteers. Biological Psychiatry 78(8): 572–581.
Google Scholar | Crossref | Medline Krebs, TS, Johansen, P (2013) Over 30 million psychedelic users in the United States. F1000Research 2: 98.
Google Scholar | Crossref | Medline Leary, T, Litwin, GH, Metzner, R (1963) Reactions to psilocybin administered in a supportive environment. Journal of Nervous and Mental Disease 137(6): 561–573.
Google Scholar | Crossref | Medline Lindeman, M, Koirikivi, I, Lipsanen, J (2018) Pictorial Empathy Test (PET): An easy-to-use method for assessing affective empathic reactions. European Journal of Psychological Assessment 34(6): 421–431.
Google Scholar | Crossref Litjens, RPW, Brunt, T, Alderliefste, GJ, et al. (2014) Hallucinogen persisting perception disorder and the serotonergic system: A comprehensive review including new MDMA-related clinical cases. European Neuropsychopharmacology 24(8): 1309–1323.
Google Scholar | Crossref | Medline Madsen, MK, Fisher, PM, Burmester, D, et al. (2019) Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Neuropsychopharmacology 44(7): 1328–1334.
Google Scholar | Crossref | Medline Mason, NL, Mischler, E, Uthaug, MV, et al. (2019) Sub-acute effects of psilocybin on empathy, creative thinking, and subjective well-being. Journal of Psychoactive Drugs 51: 123–134.
Google Scholar | Crossref | Medline Moreno, FA, Wiegand, CB, Taitano, EK, et al. (2006) Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder. Journal of Clinical Psychiatry 67(11): 1735–1740.
Google Scholar | Crossref | Medline | ISI Murphy, RO, Ackermann, KA, Handgraaf, MJJ (2011) Measuring social value orientation. Judgment and Decision Making 6(8): 771–781.
Google Scholar | ISI McManus, S, Bebbington, P, Jenkins, R, Brugha, T (eds.) (2016) Mental health and wellbeing in England: Adult Psychiatric Morbidity Survey 2014. Leeds: NHS Digital. https://webarchive.nationalarchives.gov.uk/ukgwa/20180328140249mp_/http://digital.nhs.uk/media/35660/APMS-2014-Full-Report/pdf/Mental_health_and_wellbeing_in_England_full_report
Google Scholar | Crossref Nichols, DE (2016) Psychedelics. Pharmacological Reviews 68(2): 264–355.
Google Scholar | Crossref | Medline Pahnke, W (1963) Drugs and mysticism: An analysis of the relationship between psychedelic drugs and the mystical consciousness. PhD Dissertation, Harvard University, Cambridge, MA.
Google Scholar Passie, T (2005) A history of the use of psilocybin in psychotherapy. In: R, Metzner (ed.) Sacred Mushroom of Visions: Teonanácatl: A Sourcebook on the Psilocybin Mushroom. Rochester, VT: Park Street Press, pp.113–138.
Google Scholar Passie, T, Seifert, J, Schneider, U, et al. (2002) The pharmacology of psilocybin. Addiction Biology 7(4): 357–364.
Google Scholar | Crossref | Medline | ISI Pokorny, T, Preller, KH, Kometer, M, et al. (2017) Effect of psilocybin on empathy and moral decision-making. International Journal of Neuropsychopharmacology 20(9): 747–757.
Google Scholar | Crossref | Medline Preller, KH, Pokorny, T, Hock, A, et al. (2016) Effects of serotonin 2A/1A receptor stimulation on social exclusion processing. Proceedings of the National Academy of Sciences of the United States of America 113(18): 5119–5124.
Google Scholar | Crossref | Medline Ross, S, Bossis, A, Guss, J, et al. (2016) Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: A randomized controlled trial. Journal of Psychopharmacology 30(12): 1165–1180.

留言 (0)

沒有登入
gif