Enzyme-Responsive Drug Release

In article number 2102080, Zhengbao Zha, Hua Wang, and co-workers encapsulate chemotherapeutic DOX and aTIGIT drugs together in a gelatin-based hydrogel to synergistically realize immunogenic tumors, which promote the infiltration of NK and effector T cells and then are further stimulated by the subsequently released aTIGIT, to boost multilayered innate and adaptive immune responses for durable and long-lasting anti-tumor therapy.