Table S1. Univariate analysis using cox proportional hazards model with hazard ratios using CR only cohort, comparing several variables at baseline (age, gender, involved heavy chain, and ASCT status) and at the time of CR (thrombocytopenia, hypoalbuminemia, immunoparesis). Immunoparesis 1: Either IgG or IgM below the lower limits of normal per internal laboratory range (IgG < 600 mg/dl, IgM < 40 mg/dl). Immunoparesis 2: Both IgG and IgM below the lower limits of normal per internal laboratory range. Thrombocytopenia (platelet count < 150× 103/μl). Hypoalbuminemia (albumin < 3.5 g/dl).

Figure S1. Kaplan-Meier plot comparing OS in patients achieving a CR within 24 months from diagnosis. A-Age: Age < 75 years median OS 121 months; Age ≥ 75 years median OS 43.9 months. B-Sex: Female median OS 153 months; Males median OS 95.5 months. C-Hypoalbuminemia: Albumin at CR ≥ 3.5 g/dl median OS 128 months; Albumin at CR < 3.5 g/dl median OS 98 months. D-Involved heavy chain: IgG median OS 127 months; non-IgG median OS 84 months. OS, overall survival.