The development of an easy-to-use, low-cost, and visualized detection platform for screening human dental caries and periodontal diseases is in urgent demand. In this work, we present a Au@Ag nanorods-polydimethylsiloxane (Au@Ag NRs-PDMS) wearable mouthguard, which can visualize the tooth lesion sites through the color change of it at the corresponding locations. The Au@Ag NRs-PDMS composite exhibited a distinct color response to hydrogen sulfide (H2S) gas generated by bacterial decay at the lesion sites. Moreover, the Au@Ag NRs-PDMS mouthguard was demonstrated to own desired mechanical properties, excellent chemical stability as well as good biocompatibility, and could accurately locate the lesion sites in human oral cavity. These findings suggest that our mouthguard has the potential to be utilized on a large scale to help people self-monitor their oral health in daily life, and treat oral diseases locally.

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