Psilocybin microdosing does not affect emotion-related symptoms and processing: A preregistered field and lab-based study

Amanzio, M, Benedetti, F (1999) Neuropharmacological dissection of placebo analgesia: Expectation-activated opioid systems versus conditioning-activated specific subsystems. The Journal of Neuroscience 19(1): 484–494.
Google Scholar | Crossref | Medline Anderson, T, Petranker, R, Rosenbaum, D, et al. (2019) Microdosing psychedelics: Personality, mental health, and creativity differences in microdosers. Psychopharmacology 236(2): 731–740.
Google Scholar | Crossref | Medline ANOVA_power (n.d.) Available at: https://shiny.ieis.tue.nl/anova_power/
Google Scholar Bener, A, Alsulaiman, R, Doodson, LG, et al. (2016) Comparison of reliability and validity of the breast cancer Depression Anxiety Stress Scales (DASS-21) with the beck depression inventory-(BDI-II) and hospital anxiety and depression scale (HADS). International Journal of Behavioral Research & Psychology 4(4): 196–202.
Google Scholar Bernasconi, F, Schmidt, A, Pokorny, T, et al. (2013) Spatiotemporal brain dynamics of emotional face processing modulations induced by the serotonin 1A/2A receptor agonist psilocybin. Cerebral Cortex 24(12): 3221–3231.
Google Scholar | Crossref | Medline Bershad, AK, Schepers, ST, Bremmer, MP, et al. (2019) Acute subjective and behavioral effects of microdoses of lysergic acid diethylamide in healthy human volunteers. Biological Psychiatry 86(10): 792–800.
Google Scholar | Crossref | Medline Bornemann, B, Herbert, BM, Mehling, WE, et al. (2015) Differential changes in self-reported aspects of interoceptive awareness through 3 months of contemplative training. Frontiers in Psychology 5: 1504.
Google Scholar | Crossref | Medline Bornemann, J (2020) The viability of microdosing psychedelics as a strategy to enhance cognition and well-being – An early review. Journal of Psychoactive Drugs 52(4): 300–308.
Google Scholar | Crossref | Medline Cameron, LP, Benson, CJ, Defelice, BC, et al. (2019) Chronic, intermittent microdoses of the psychedelic N, N-Dimethyltryptamine (DMT) produce positive effects on mood and anxiety in rodents. ACS Chemical Neuroscience 10(7): 3261–3270.
Google Scholar | Crossref | Medline Cameron, LP, Nazarian, A, Olson, DE (2020) Psychedelic microdosing: Prevalence and subjective effects. Journal of Psychoactive Drugs 52(2): 113–122.
Google Scholar | Crossref | Medline Christoffel, DJ, Golden, SA, Russo, SJ (2011) Structural and synaptic plasticity in stress related disorders. Reviews in the Neurosciences 22(5): 535–549.
Google Scholar | Crossref | Medline Clark, A (2013) Whatever next? Predictive brains, situated agents, and the future of cognitive science. The Behavioral and Brain Sciences 36(3): 181–204.
Google Scholar | Crossref | Medline | ISI Erb, SJ, Schappi, JM, Rasenick, MM (2016) Antidepressants accumulate in lipid rafts independent of monoamine transporters to modulate redistribution of the G protein, Gαs. Journal of Biological Chemistry 291(38): 19725–19733.
Google Scholar | Crossref | Medline Erickson, K, Drevets, WC, Clark, L, et al. (2005) Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder. American Journal of Psychiatry 162(11): 2171–2173.
Google Scholar | Crossref | Medline Fadiman, J (2011) The Psychedelic Explorer’s Guide: Safe, Therapeutic, and Sacred Journeys (1st edn). Rochester, VT: Inner Traditions Bear and Company.
Google Scholar Fadiman, J, Korb, S (2019) Might microdosing psychedelics be safe and beneficial? An initial exploration. Journal of Psychoactive Drugs 51: 118–122.
Google Scholar | Crossref | Medline Family, N, Maillet, E, Williams, L, et al. (2020) Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers. Psychopharmacology 237: 841–853.
Google Scholar | Crossref | Medline Füstös, J, Gramann, K, Herbert, B, et al. (2013) On the embodiment of emotion regulation: Interoceptive awareness facilitates reappraisal. Social Cognitive and Affective Neuroscience 8(8): 911–917.
Google Scholar | Crossref | Medline Hanson, ND, Owens, MJ, Nemeroff, CB (2011) Depression, antidepressants, and neurogenesis: A critical reappraisal. Neuropsychopharmacology 36(13): 2589–2602.
Google Scholar | Crossref | Medline | ISI Harmer, CJ, Goodwin, GM, Cowen, PJ (2009) Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action. British Journal of Psychiatry 195(2): 102–108.
Google Scholar | Crossref | Medline | ISI Henry, JD, Crawford, JR (2005) The short-form version of the Depression Anxiety Stress Scales (DASS-21): Construct validity and normative data in a large non-clinical sample. British Journal of Clinical Psychology 44(2): 227–239.
Google Scholar | Crossref | Medline | ISI Horsley, RR, Palenicek, T, Kolin, J, et al. (2018) Psilocin and ketamine microdosing: Effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats. Behavioural Pharmacology 29(6): 530–536.
Google Scholar | Crossref | Medline Hutten, N, Mason, NL, Dolder, PC, et al. (2019) Self-rated effectiveness of microdosing with psychedelics for mental and physical health problems among microdosers. Frontiers in Psychiatry 10: 672.
Google Scholar | Crossref | Medline Hutten, N, Mason, NL, Dolder, PC, et al. (2020) Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study. Eur Neuropsychopharmacol 41: 81–91.
Google Scholar | Crossref | Medline Johnstad, PG (2018) Powerful substances in tiny amounts. Nordic Studies on Alcohol and Drugs 35(1): 39–51.
Google Scholar | SAGE Journals | ISI Kaertner, LS, Steinborn, MB, Kettner, H, et al. (2021) Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing. Scientific Reports 11(1): 1941.
Google Scholar | Crossref | Medline Kirsch, I (2014) Antidepressants and the placebo effect. Zeitschrift für Psychologie 222(3): 128134.
Google Scholar Kometer, M, Schmidt, A, Bachmann, R, et al. (2012) Psilocybin biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic subreceptors. Biological Psychiatry 72(11): 898–906.
Google Scholar | Crossref | Medline Kraehenmann, R, Preller, KH, Scheidegger, M, et al. (2015) Psilocybin-induced decrease in amygdala reactivity correlates with enhanced positive mood in healthy volunteers. Biological Psychiatry 78(8): 572–581.
Google Scholar | Crossref | Medline Lea, T, Amada, N, Jungaberle, H, et al. (2020) Microdosing psychedelics: Motivations, subjective effects and harm reduction. The International Journal on Drug Policy 75: 102600.
Google Scholar | Crossref | Medline Lovibond, P, Lovibond, S (1995) The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the beck depression and anxiety inventories. Behaviour Research and Therapy 33(3): 335–343.
Google Scholar | Crossref | Medline | ISI Ly, C, Greb, AC, Cameron, LP, et al. (2018) Psychedelics Promote Structural and Functional Neural Plasticity. Cell Reports 23(11): 3170–3182.
Google Scholar | Crossref | Medline Madsen, MK, Fisher, PM, Burmester, D, et al. (2019) Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Neuropsychopharmacology 44(7): 1328–1334.
Google Scholar | Crossref | Medline Mehling, WE, Price, C, Daubenmier, JJ, et al. (2012) The Multidimensional Assessment of Interoceptive Awareness (MAIA). PLoS ONE 7(11): e48230.
Google Scholar | Crossref | Medline Meissner, K, Kohls, N, Colloca, L (2011) Introduction to placebo effects in medicine: Mechanisms and clinical implications. Philosophical Transactions of the Royal Society B: Biological Sciences 366(1572): 1783–1789.
Google Scholar | Crossref | Medline Norton, PJ (2007) Depression anxiety and stress scales (DASS-21): Psychometric analysis across four racial groups. Anxiety, Stress & Coping 20(3): 253–265.
Google Scholar | Crossref | Medline | ISI Olson, DE (2018) Psychoplastogens: A promising class of plasticity-promoting neurotherapeutics. Journal of Experimental Neuroscience. Epub ahead of print 19 September. DOI: 10.1177/1179069518800508.
Google Scholar | SAGE Journals Osman, A, Wong, JL, Bagge, CL, et al. (2012) The Depression Anxiety Stress Scales-21 (DASS-21): Further examination of dimensions, scale reliability, and correlates. Journal of Clinical Psychology 68(12): 1322–1338.
Google Scholar | Crossref | Medline Passie, T, Seifert, J, Schneider, U, et al. (2002) The pharmacology of psilocybin. Addiction Biology 7(4): 357–364.
Google Scholar | Crossref | Medline | ISI Petranker, R, Anderson, T, Maier, L, et al. (2020) Microdosing psychedelics: Subjective benefits and challenges, substance testing behavior, and the relevance of intention. Journal of Psychopharmacology. Epub ahead of print 8 October. DOI: 10.1177/0269881120953994.
Google Scholar | SAGE Journals Pink-Hashkes, S, van Rooij, I, Kwisthout, J (2017) Perception is in the details: A predictive coding account of the psychedelic phenomenon. In: Proceedings of the 39th Annual Meeting of the Cognitive Science Society, London, , pp. 2907–2912. London: Cognitive Science Society.
Google Scholar Polito, V, Stevenson, D (2019) A systematic study of microdosing psychedelics. PLoS ONE 14(2): e0211023.
Google Scholar | Crossref | Medline Prochazkova, L, van Elk, M, Marschall, J, et al. (2021) Microdosing psychedelics and its effect on creativity: Lessons learned from three double-blind placebo controlled longitudinal trials. PsyArxiv Preprints. DOI: 10.31234/osf.io/emcxw.
Google Scholar | Crossref Schalk, JV, Hawk, ST, Fischer, AH, et al. (2011) Moving faces, looking places: Validation of the Amsterdam Dynamic Facial Expression Set (ADFES). Emotion 11(4): 907–920.
Google Scholar | Crossref | Medline Schmidt, A, Kometer, M, Bachmann, R, et al. (2012) The NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on structural encoding of emotional face expressions. Psychopharmacology 225(1): 227–239.
Google Scholar | Crossref | Medline Schulz, K, Fan, J, Magidina, O, et al. (2007) Does the emotional go/no-go task really measure behavioral inhibition? Convergence with measures on a non-emotional analog. Archives of Clinical Neuropsychology 22(2): 151–160.
Google Scholar | Crossref | Medline Szigeti, B, Kartner, L, Blemings, A, et al. (2021) Self-blinding citizen science to explore psychedelic microdosing. eLife 10: e62878.
Google Scholar | Crossref | Medline Tottenham, N, Hare, TA, Casey, BJ (2011) Behavioral assessment of emotion discrimination, emotion regulation, and cognitive control in childhood, adolescence, and adulthood. Frontiers in Psychology 2: 39.
Google Scholar | Crossref | Medline van Elk, M, Fejer, G, Lempe, P, et al. (2021) Effects of psilocybin microdosing on awe and aesthetic experiences: A preregistered field and lab-based study. Psychopharmacology. Epub ahead of print 30 April. DOI: 10.1007/s00213-021-05857-0.
Google Scholar | Crossref | Medline Vollenweider, FX (2001) Brain mechanisms of hallucinogens and entactogens. Dialogues in Clinical Neuroscience 3(4): 265–279.
Google Scholar |

留言 (0)

沒有登入
gif