AGER gene variant as a risk factor for juvenile idiopathic arthritis

Background

The AGER gene encodes a cell surface multiligand receptor of advanced glycation end-products that are also capable of binding other molecules and are involved in numerous pathways related to inflammation, apoptosis, immunity and so on. In this study, we aimed to investigate whether the AGER rs1035798 (G>A) intronic polymorphism, showing an association with multiple sclerosis and rheumatoid arthritis in adults, is related to juvenile idiopathic arthritis (JIA).

Methods

Caucasian children from the Belarusian population were enrolled in the study. In total, there were 201 cases with JIA, 37 with juvenile systemic lupus erythematosus, 222 children with the articular syndrome of non-autoimmune etiology (positive control for JIA), and 365 negative controls (children without any autoimmune or inflammatory diseases). Genomic DNA samples from the patients and controls were genotyped by real-time PCR instruments.

Results

A marked association of the homozygous AA rs1035798 genotype with JIA (p=5×10-4) was found. Allele A was also associated with JIA (p=0.0058), as well as with the articular syndrome of non-autoimmune etiology (p=0.0264). The highest frequencies of the AA genotype were found in the subgroups of JIA patients with polyarthritis or severe oligoarthritis. The AA genotype patients also had the smallest mean age of the JIA onset.

Conclusions

Our results demonstrate that the AGER rs1035798 AA genotype is a risk factor for JIA in Belarusian children. They also suggest a link between the AGER AA genotype and the risk of JIA early onset and severity. However, the functional relevance of the rs1035798 polymorphism is still unclear.

留言 (0)

沒有登入
gif