Neurodegenerative Diseases
Rosas I. · Morís G. · Coto E. · Blázquez M. · Suárez E. · García-Fernández C. · Siso P. · Martínez C. · Pérez-Oliveira S. · Álvarez V. · Menéndez-González M.Log in to MyKarger to check if you already have access to this content.
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Article / Publication Details AbstractAbstract Background: Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies indicate a a decreased incidence of most cancer types in Parkinson's disease (PD) patients and some PD genes are involved in cancer networks. Objective : The aim of this study is to assess the influence of several factors in the risk of cancer in a cohort of 753 PD patients and to study how these variables interact with each other. Methods: We analyzed the effect of gender, tobacco, alcohol, type of PD (genetic (gPD) or idiopathic PD (iPD)) and two genetic variants, previouly associated with cancer, rs5848- GRN, rs1042522- TP53. Results: A higher age at PD onset was observed in patients that develop cancer before PD (p
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