Neurotransmitter Precursor Amino Acid Ratios Show Differential, Inverse Correlations with Depression Severity in the Low and High Depression Score Range

1. Aan Het Rot, M, Mathew, SJ, Charney, DS. Neurobiological mechanisms in major depressive disorder. Can Med Assoc J. 2009;180:305-313.
Google Scholar | Crossref | Medline | ISI2. Krishnan, V, Nestler, EJ. Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry. 2010;167:1305-1320.
Google Scholar | Crossref | Medline | ISI3. Rush, AJ, Trivedi, MH, Wisniewski, SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163:1905-1917.
Google Scholar | Crossref | Medline | ISI4. Turck, CW. Biomarkers for Psychiatric Disorders. 1st ed. Springer; 2009.
Google Scholar | Crossref5. Padmos, RC, Hillegers, MH, Knijff, EM, et al. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry. 2008;65:395-407.
Google Scholar | Crossref | Medline6. Dantzer, R, Wollman, E, Vitkovic, L, Yirmiya, R. Cytokines and depression: fortuitous or causative association? Mol Psychiatry. 1999;4:328-332.
Google Scholar | Crossref | Medline | ISI7. Strasser, B, Sperner-Unterweger, B, Fuchs, D, Gostner, JM. Mechanisms of inflammation-associated depression: immune influences on tryptophan and phenylalanine metabolisms. Curr Top Behav Neurosci. 2017;31:95-115.
Google Scholar | Crossref | Medline8. Bardeleben, U, Holsboer, F. Cortisol response to a combined dexamethasone-human corticotrophin-releasing hormone challenge in patients with depression. J Neuroendocrinol. 1989;1:485-488.
Google Scholar | Crossref | Medline9. Haroon, E, Raison, CL, Miller, AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology. 2012;37:137-162.
Google Scholar | Crossref | Medline | ISI10. Capuron, L, Neurauter, G, Musselman, DL, et al. Interferon-alpha-induced changes in tryptophan metabolism: relationship to depression and paroxetine treatment. Biol Psychiatry. 2003;54:906-914.
Google Scholar | Crossref | Medline | ISI11. Pantouris, G, Serys, M, Yuasa, HJ, Ball, HJ, Mowat, CG. Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1. Amino Acids. 2014;46:2155-2163.
Google Scholar | Crossref | Medline | ISI12. Widner, B, Laich, A, Sperner-Unterweger, B, Ledochowski, M, Fuchs, D. Neopterin production, tryptophan degradation, and mental depression – what is the link? Brain Behav Immun. 2002;16:590-595.
Google Scholar | Crossref | Medline | ISI13. Oxenkrug, GF. Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later. Isr J Psychiatry Relat Sci. 2010;47:56-63.
Google Scholar | Medline14. Myint, AM. Kynurenines: from the perspective of major psychiatric disorders. FEBS J. 2012;279:1375-1385.
Google Scholar | Crossref | Medline | ISI15. Fukui, S, Schwarcz, R, Rapoport, SI, Takada, Y, Smith, QR. Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem. 1991;56:2007-2017.
Google Scholar | Crossref | Medline | ISI16. Sperner-Unterweger, B, Kohl, C, Fuchs, D. Immune changes and neurotransmitters: possible interactions in depression? Prog Neuropsychopharmacol Biol Psychiatry. 2014;48:268-276.
Google Scholar | Crossref | Medline17. Werner-Felmayer, G, Golderer, G, Werner, ER. Tetrahydrobiopterin biosynthesis, utilization and pharmacological effects. Curr Drug Metab. 2002;3:159-173.
Google Scholar | Crossref | Medline | ISI18. Neurauter, G, Schrocksnadel, K, Scholl-Burgi, S, et al. Chronic immune stimulation correlates with reduced phenylalanine turnover. Curr Drug Metab. 2008;9:622-627.
Google Scholar | Crossref | Medline19. Sucher, R, Schroecksnadel, K, Weiss, G, Margreiter, R, Fuchs, D, Brandacher, G. Neopterin, a prognostic marker in human malignancies. Cancer Lett. 2010;287:13-22.
Google Scholar | Crossref | Medline20. Schneemann, M, Schoedon, G, Hofer, S, Blau, N, Guerrero, L, Schaffner, A. Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J Infect Dis. 1993;167:1358-1363.
Google Scholar | Crossref | Medline | ISI21. Pike, JL, Smith, TL, Hauger, RL, et al. Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans. Psychosom Med. 1997;59:447-457.
Google Scholar | Crossref | Medline | ISI22. Ising, M, Horstmann, S, Kloiber, S, et al. Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression – a potential biomarker? Biol Psychiatry. 2007;62:47-54.
Google Scholar | Crossref | Medline | ISI23. Hufner, K, Galffy, M, Egeter, J, et al. Acute and chronic mental stress both influence levels of neurotransmitter precursor amino acids and derived biogenic amines. Brain Sci. 2020;10:322.
Google Scholar | Crossref24. Koudouovoh-Tripp, P, Hufner, K, Egeter, J, et al. Stress enhances proinflammatory platelet activity: the impact of acute and chronic mental stress. J Neuroimmune Pharmacol. 2021;16:500-512.
Google Scholar | Crossref | Medline25. Snaith, RP, Harrop, FM, Newby, DA, Teale, C. Grade scores of the montgomery—Åsberg depression and the clinical anxiety scales. Br J Psychiatry. 1986;148:599-601.
Google Scholar | Crossref | Medline | ISI26. Montgomery, SA, Asberg, M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382-389.
Google Scholar | Crossref | Medline | ISI27. Sheehan, DV, Lecrubier, Y, Sheehan, KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59:22-33;quiz 34-57.
Google Scholar | Medline | ISI28. Hagströmer, M, Oja, P, Sjöström, M. The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity. Public Health Nutr. 2006;9:755-762.
Google Scholar | Crossref | Medline | ISI29. Buysse, DJ, Reynolds, CF, Monk, TH, Berman, SR, Kupfer, DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193-213.
Google Scholar | Crossref | Medline | ISI30. Vella, EJ, Friedman, BH. Hostility and anger in: cardiovascular reactivity and recovery to mental arithmetic stress. Int J Psychophysiol. 2009;72:253-259.
Google Scholar | Crossref | Medline | ISI31. Garde, AH, Laursen, B, Jorgensen, AH, Jensen, BR. Effects of mental and physical demands on heart rate variability during computer work. Eur J Appl Physiol. 2002;87:456-461.
Google Scholar | Crossref | Medline32. Cohen, S, Kamarck, T, Mermelstein, R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385-396.
Google Scholar | Crossref | Medline | ISI33. Laux, L, Glanzmann, P, Schaffner, P, Spielberger, CD. Das State-Trait-Angstinventar (STAI), Manual. Beltz Test; 1981.
Google Scholar34. Widner, B, Werner, ER, Schennach, H, Wachter, H, Fuchs, D. Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem. 1997;43:2424-2426.
Google Scholar | Crossref | Medline | ISI35. Capuron, L, Schroecksnadel, S, Feart, C, et al. Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry. 2011;70:175-182.
Google Scholar | Crossref | Medline | ISI36. Giustarini, D, Dalle-Donne, I, Colombo, R, Milzani, A, Rossi, R. Adaptation of the Griess reaction for detection of nitrite in human plasma. Free Radic Res. 2004;38:1235-1240.
Google Scholar | Crossref | Medline | ISI37. Geisler, S, Mayersbach, P, Becker, K, Schennach, H, Fuchs, D, Gostner, JM. Serum tryptophan, kynurenine, phenylalanine, tyrosine and neopterin concentrations in 100 healthy blood donors. Pteridines. 2015;26:31-36.
Google Scholar | Crossref38. Dhabhar, FS. The short-term stress response – mother nature’s mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity. Front Neuroendocrinol. 2018;49:175-192.
Google Scholar | Crossref | Medline39. Thony, B, Auerbach, G, Blau, N. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J. 2000;347:1-16.
Google Scholar | Crossref | Medline | ISI40. Crabtree, MJ, Channon, KM. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide. 2011;25:81-88.
Google Scholar | Crossref | Medline | ISI41. Gostner, JM, Geisler, S, Stonig, M, Mair, L, Sperner-Unterweger, B, Fuchs, D. Tryptophan metabolism and related pathways in psychoneuroimmunology: the impact of nutrition and lifestyle. Neuropsychobiology. 2020;79:89-99.
Google Scholar | Crossref | Medline42. Lundberg, JO, Weitzberg, E, Gladwin, MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7:156-167.
Google Scholar | Crossref | Medline | ISI43. Vancassel, S, Capuron, L, Castanon, N. Brain kynurenine and BH4 pathways: relevance to the pathophysiology and treatment of inflammation-driven depressive symptoms. Front Neurosci. 2018;12:499.
Google Scholar | Crossref | Medline44. Hufner, K, Oberguggenberger, A, Kohl, C, et al. Levels in neurotransmitter precursor amino acids correlate with mental health in patients with breast cancer. Psychoneuroendocrinology. 2015;60:28-38.
Google Scholar | Crossref | Medline45. Hüfner, K, Fuchs, D, Blauth, M, Sperner-Unterweger, B. How acute and chronic physical disease may influence mental health – an analysis of neurotransmitter precursor amino acid levels. Psychoneuroendocrinology. 2019;106:95-101.
Google Scholar | Crossref | Medline46. Mac Giollabhui, N, Ng, TH, Ellman, LM, Alloy, LB. The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression. Mol Psychiatry. Published online August 17, 2020. doi:10.1038/s41380-020-00867-4
Google Scholar | Crossref47. Kofler, M, Schiefecker, AJ, Gaasch, M, et al. A reduced co

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