4- Division of Pulmonary, Critical Care and Sleep, Yale School of Medicine, New Haven, CT/US

FNR is the guarantor of the paper taking the responsibility for the integrity of the work as a whole, from inception to published article

FNR, PN, ABW, RSJE, BM, JAL, ARH, GRW were involved in the conceptualization; FNR, PN, EH, IS, GVSF, JCR, RSJE, SYA, ARH were involved in data collection and analysis. All authors participated in writing and approval of the final manuscript.

This study was supported in part by NHLBI grants, 1K23HL136905 (F.N.R) 5R01HL116473 (R.S.J.E. and G.R.W), 1R01HL149877 (R.S.J.E) , 5K08HL145118 (S.Y.A.)..

RSJE reports grants from NIH-NHLBI, during the conduct of the study; personal fees from LeukoLabs, grants and personal fees from Boehringer Ingelheim, personal fees from Chiesi USA Inc., from null, outside the submitted work; and he is also a founder and co-owner of Quantitative Imaging Solutions which is a company that provides image based consulting and develops software to enable data sharing.

GRW reports grants from NIH, grants and other from Boehringer Ingelheim, other from Quantitative Imaging Solutions, other from PulmonX, grants and other from Janssen Pharmaceuticals, other from GlaxoSmithKline, other from Novartis, other from Vertex, other from CSL Behring, outside the submitted work; and Dr. Washko's spouse works for Biogen. He is also a founder and co-owner of Quantitative Imaging Solutions which is a company that provides image based consulting and develops software to enable data sharing.