Anecdotal reports linking minimal change disease (MCD) to vaccinations possibly due to immune dysregulation,1 including influenza vaccine,2 pneumococcal,3 meningococcal C vaccines,4 and BNT162b2 coronavirus disease 2019 (COVID-19) vaccine (Pfizer-BioNTech)5,6 have been published. We report 2 cases of biopsy-proven MCD relapsing within 2 days of receiving an AstraZeneca COVID-19 vaccine.