Genetic Counseling for Men with Prostate Cancer

Giri V.N. Hyatt C. Gomella L.G.

GT for men with prostate cancer: Navigating an expanding new world of genetic evaluation for precision therapy and precision management.

J Clin Oncol. 37: 1455-1459

The historical perspective: sheldon reed and 50 years of genetic counseling.

J Genet Couns. 6: 375-377Uhlmann W.R. Schuette J.L. Yashar B.

A guide to genetic counseling.

2nd edition. Wiley-Blackwell, Hoboken (NJ)Resta R. Biesecker B.B. Bennett R.L. et al.

A new definition of genetic counseling: national society of genetic counselors’ task force report.

J Genet Counsel. 15: 77-83Hyatt C. Russo J. McDougall C.

Genetic counseling perspective of engagement with urology and primary care.

Can J Urol. 26: 52-53Giri V.N. Knudsen K.E. Kelly W.K. et al.

Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019.

J Clin Oncol. 38: 2798-2811Hampel H. Bennett R.L. Buchanan A. et al.

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

Genet Med. 17: 70-87Bensend T.A. Veach P.M. Niendorf K.B.

What’s the harm? Genetic counselor perceptions of adverse effects of genetics service provision by non-genetics professionals.

J Genet Couns. 23: 48-63Hampel H. Grubs R.E. Walton C.S. et al.

Genetic counseling practice analysis.

J Genet Couns. 18: 205-216Bjorvatn C. Eide G.E. Hanestad B.R. et al.

Risk perception, worry and satisfaction related to genetic counseling for hereditary cancer.

J Genet Couns. 16: 211-222Bratt O. Damber J.E. Emanuelsson M. et al.

Risk perception, screening practice and interest in genetic testing among unaffected men in families with hereditary prostate cancer.

Eur J Cancer. 36: 235-241Culver J.O. Brinkerhoff C.D. Clague J. et al.

Variants of uncertain significance in BRCA testing: Evaluation of surgical decisions, risk perception, and cancer distress.

Clin Genet. 84: 464-472Cicero G. DeLuca R. Dorangricchia P. et al.

Risk perception and psychological distress in genetic counselling for hereditary breast and/or ovarian cancer.

J Genet Couns. 26: 999-1007Palmero E.I. Campacci N. Schuler-Faccini L. et al.

Cancer-related worry and risk perception in Brazilian individuals seeking genetic counseling for hereditary breast cancer.

Genet Mol Biol. 43: 1-7Bennett R.L. Steinhaus French K. Resta R.G. et al.

Standardized human pedigree nomenclature: Update and assessment of the recommendations of the National Society of Genetic Counselors.

J Genet Couns. 17: 424-433Riley B.D. Culver J.O. Skrzynia C. et al.

Essential elements of genetic cancer risk assessment, counseling, and testing: Updated recommendations of the National Society of Genetic Counselors.

J Genet Couns. 21: 151-161Balmaña J. Digiovanni L. Gaddam P. et al.

Conflicting interpretation of genetic variants and cancer risk by commercial laboratories as assessed by the prospective registry of multiplex testing.

J Clin Oncol. 34: 4071-4078Richards S. Aziz N. Bale S. et al.

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

Genet Med. 17: 405-423Mersch J. Brown N. Pirzadeh-Miller S. et al.

Prevalence of variant reclassification following hereditary cancer genetic testing.

JAMA. 320: 1266-1274Giri V.N. Obeid E. Gross L. et al.

Inherited Mutations in Males Undergoing Multigene Panel Testing for PCA – emerging implications for personalized prostate cancer genetic evaluation.

J Clin Oncol. https://doi.org/10.1200/PO.16.00039Giri V.N. Obeid E. Hegarty S.E. et al.

Understanding of multigene test results among males undergoing germline testing for inherited prostate cancer: implications for genetic counseling.

Prostate. 78: 879-888

Meiser B Psychological impact of genetic testing for cancer susceptibility: an update of the literature.

Psychooncology. 14: 1060-1074Hadley D.W. Ashida S. Jenkins J.F. et al.

Generation after generation: exploring the psychological impact of providing genetic services through a cascading approach.

Genet Med. 12: 808-815

The role of BRCA1 and BRCA2 in prostate cancer.

Asian J Androl. 14 () (): 409-414Giri V.N. Hegarty S.E. Hyatt C. et al.

Germline genetic testing for inherited prostate cancer in practice: Implications for genetic testing, precision therapy, and cascade testing.

Prostate. 79 () (): 333-339

BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian.

MedGenMed. 7 () (): 60Nyberg T. Frost D. Barrowdale D. et al.

Prostate Cancer Risks for Male BRCA1 and BRCA2 Mutation Carriers: A Prospective Cohort Study.

Eur Urol. 77: 24-35

Re: Prostate Cancer Risks for Male BRCA1 and BRCA2 Mutation Carriers: A Prospective Cohort Study.

J Urol. 203: 463-464Castro E. Goh C. Olmos D. et al.

Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer.

J Clin Oncol. 31: 1748-1757Struewing J.P. Hartge P. Wacholder S. et al.

The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.

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Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

Am J Hum Genet. 62: 676-689Kuchenbaecker K.B. Hopper J.L. Barnes D.R. et al.

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers.

JAMA. 317: 2402-2416Breast Cancer Linkage Consortium

Cancer risks in BRCA2 mutation carriers.

J Natl Cancer Inst. 91: 1310-1316

Fanconi anaemia and cancer: an intricate relationship.

Nat Rev Cancer. 18: 168-185Domchek S.M. Tang J. Stopfer J. et al.

Biallelic deleterious BRCA1 mutations in a woman with early-onset ovarian cancer.

Cancer Discov. 3: 399-405Sawyer S.L. Tian L. Kähkönen M. et al.

Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype.

Cancer Discov. 5: 135-142Ewing C.M. Ray A.M. Lange E.M. et al.

Germline mutations in HOXB13 and prostate-cancer risk.

N Engl J Med. 366: 141-149Laitinen V.H. Wahlfors T. Saaristo L. et al.

HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk.

Cancer Epidemiol Biomarkers Prev. 22: 452-460Karlsson R. Aly M. Clements M. et al.

A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk.

Eur Urol. 65: 169-176Bauer C.M. Ray A.M. Halstead-Nussloch B.A. et al.

Hereditary prostate cancer as a feature of Lynch Syndrome.

Fam Cancer. 10 () (): 37-42Soravia C. Klift H.M. Brundler M.-A. et al.

Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum.

Am J Med Genet A. 121 () (): 159-162Shan A. Wick M. Persons D.

Microsatellite instability in prostate cancer.

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Genetics, diagnosis and treatment of Lynch syndrome: Old lessons and current challenges (Review).

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Milestones of Lynch syndrome: 1895–2015.

Nat Rev Cancer. 15: 181-194Jenkins M.A. Baglietto L. Dowty J.G. et al.

Cancer risks for mismatch repair gene mutation carriers: a population-based early onset case-family study.

Clin Gastroenterol Hepatol. 4: 489-498Beebe-Dimmer J.L. Kapron A.L. Fraser A.M. et al.

Risk of prostate cancer associated with familial and hereditary cancer syndromes.

J Clin Oncol. 38: 1807-1813Wimmer K. Kratz C.P. Vasen H.F. et al.

Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium 'care for CMMRD' (C4CMMRD).

J Med Genet. 51: 355-365Na R. Zheng S.L. Han M. et al.

Germline Mutations in ATM and BRCA1/2 distinguish risk for lethal and indolent prostate cancer and are associated with early age at death.

Eur Urol. 71: 740-747Carter H.B. Helfand B. Mamawala M. et al.

Germline Mutations in ATM and BRCA1/2 are associated with grade reclassification in men on active surveillance for prostate cancer.

Eur Urol. 75: 743-749Mavrou A. Tsangaris G.T. Roma E. et al.

The ATM gene and ataxia telangiectasia.

Anticancer Res. 28: 401-405Seppälä E.H. Ikonen T. Mononen N. et al.

CHEK2 variants associate with hereditary prostate cancer.

Br J Cancer. 89: 1966-1970Cybulski C. Gorski B. Debriak T. et al.

NBS1 is a prostate cancer susceptibility gene.

Cancer Res. 64: 1215-1219Kote-Jarai Z. Jugurnauth S. Mulholland S. et al.

A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer.

Br J Cancer. 100: 426-430

Giri VN, Obeid E, Gross L, et al: Inherited mutations in males undergoing multigene panel testing for prostate cancer: emerging implications for personalized prostate cancer genetic evaluation. JCO Precis Oncol 2017;10.1200/PO.16.00039

Experiences of genetic risk: disclosure and the gendering of responsibility.

Bioethics. 15: 231-247Graves K. Gatammah R. Peshkin B. et al.

BRCA1/2 genetic testing uptake and psychosocial outcomes in men.

Fam Cancer. 1-: 213-223Rauscher E.A. Dean M. Campbell-Salome G.M.

“I Am Uncertain About What My Uncertainty Even Is”: Men’s Uncertainty and Information Management of Their BRCA-Related Cancer Risks.

J Genet Couns. 27: 1417-1427Suttman A. Pilarski R. Agnese D.M. et al.

“Second-class status?” insight into communication patterns and common concerns among men with hereditary breast and ovarian cancer syndrome.

J Genet Couns. 27: 886-893Nicolosi P. Ledet E. Yang S. et al.

Prevalence of germline variants in prostate cancer and implications for current genetic testing guidelines.

JAMA Oncol. https://doi.org/10.1001/jamaoncol.2018.6760Pritchard C.C. Mateo J. Walsh M.F. et al.

Inherited DNA-repair gene mutations in men with metastatic prostate cancer.

N Engl J Med. 375: 443-453

NCI Staff.

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Analysis of the prevalence of microsatellite instability in prostate cancer and response to immune checkpoint blockade.

JAMA Oncol. 5 (): 471-478Edwards S.M. Evans D.G. Hope Q. et al.

Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis.

Br J Cancer. 103: 918Cheng H.H. Sokolova A.O. Schaeffer E.M. et al.

Germline and Somatic Mutations in Prostate Cancer for the Clinician.

J Natl Compr Cancer Netw. 17: 515-521Mandelker D. Zhang L. Kemel Y. et al.

Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.

JAMA. 318 (): 825-835

The emerging significance of secondary germline testing in cancer genomics.

J Pathol. 244: 610-615Schrader K.A. Cheng D.T. Joseph V. et al.

Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.

JAMA Oncol. 2 (): 104-111Robinson D. Van Allen E.M. Wu Y.M. et al.

Integrative clinical genomics of advanced prostate cancer.

Cell. 161: 1215-1228Cancer Genome Atlas Research Network

The molecular taxonomy of primary prostate cancer.

Cell. 163: 1011-1025Schmidlen T. Schwartz M. DiLoreto K. et al.

Patient assessment of chatbots for the scalable delivery of genetic counseling.

J Genet Couns. 28: 1166-1177Michie S. Bron F. Bobrow M. et al.

Nondirectiveness in genetic counseling: An empirical study.

Am J Hum Genet. 60: 40-47Jamal L. Schupmann W. Berkman B.E.

An ethical framework for genetic counseling in the genomic era.

J Genet Couns. 00: 1-10Schupmann W. Jamal L. Berkman B.E.

Re-examining the ethics of genetic counseling in the genomic era.

Bioethical Inq. 17: 325-335Halbert C.H. Harrison B.W.

Genetic counseling among minority populations in the era of precision medicine.

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Genetic Information Nondiscrimination Act of 2008: Pub.L. 110-233, 122 Stat. 881 (2008).

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The Patient Protection and Affordable Care Act (PPACA). Pub. L. No. 111-148, 124 Stat. 119. (2010)

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Genetics Home Reference. Ataxia-telangiectasia.

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OMIM. Fanconi Anemia, complementation group S; FANCS.

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NCBI. GTR: Genetic Testing Registry. Fanconi Anemia, complementation group D1.

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OMIM. Mismatch Repair Cancer Syndrome; MMRCS.

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