Irisin in nonalcoholic fatty liver disease: need for an updated meta-analysis

Polyzos S.A. Kountouras J. Anastasilakis A.D. Geladari E.V. Mantzoros C.S.

Irisin in patients with nonalcoholic fatty liver disease.

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Circulating Irisin levels in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis.

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Irisin is inversely associated with intrahepatic triglyceride contents in obese adults.

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Lower circulating irisin is associated with nonalcoholic fatty liver disease and type 2 diabetes.

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A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3'UTR.

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Hepatic FNDC5 is a potential local protective factor against non-alcoholic fatty liver.

Biochim Biophys Acta Mol Basis Dis. 1866; 2020: 165705Polyzos S.A. Kountouras J. Shields K. Mantzoros C.S.

Irisin: a renaissance in metabolism?.

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.

Nature. 2012; 481: 463-468Polyzos S.A. Mantzoros C.S.

An update on the validity of irisin assays and the link between irisin and hepatic metabolism.

Metabolism. 2015; 64: 937-942Polyzos S.A. Mathew H. Mantzoros C.S.

Irisin: a true, circulating hormone.

Metabolism. 2015; 64: 1611-1618Polyzos S.A. Anastasilakis A.D. Efstathiadou Z.A. Makras P. Perakakis N. Kountouras J. et al.

Irisin in metabolic diseases.

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Established and emerging factors affecting the progression of nonalcoholic fatty liver disease.

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Complications, morbidity and mortality of nonalcoholic fatty liver disease.

Metabolism. 2020; 111S: 154170Long M.T. Gandhi S. Loomba R.

Advances in non-invasive biomarkers for the diagnosis and monitoring of non-alcoholic fatty liver disease.

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Use of imaging techniques for non-invasive assessment in the diagnosis and staging of non-alcoholic fatty liver disease.

Metabolism. 2020; 112: 154355Polyzos S.A. Mantzoros C.S.

Nonalcoholic fatty future disease.

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Addressing the epidemic of fatty liver disease: a call to action, a call to collaboration, a call to moving the field forward.

Metabolism. 2021; https://doi.org/10.1016/j.metabol.2021.154781:154781

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