Genomic Sequencing and Insight into Clinical Heterogeneity and Prognostic Pathway Genes in Patients with Metastatic Colorectal Cancer

ABL1* (NM_005157)4 (251-279), 5-6 (294-379), 7 (399-431), 8-9 (464-521)ACVRL1 (NM_000020)2 (1-21), 4 (169-175), 6 (224-253), 7 (259-286), 8 (367-395)AKT1* (NM_005163)3 (16-52), 6 (146-183), 12 (408-420)ALK* (NM_004304)22-23 (1151-1215), 25 (1251-1279)APC* (NM_000038)2-16 (1-1280), 16 (1284-1384), 16 (1388-1479), 16 (1483-1538), 16 (1543-1582), 16 (1591-2844)APEX1 (NM_001641)2-3 (1-29), 4 (109-140), 5 (165-192), 5 (224-262), 5 (278-310)AR (NM_000044)8 (870-891)ARAF (NM_001654)7 (186-226)ATM* (NM_000051)2-5 (1-166), 6-9 (174-368), 9-13 (391-708), 14-17 (713-865), 18-19 (880-974), 20-23 (1001-1134), 24-25 (1146-1217), 26 (1258-1283), 26 (1292-1331), 27-30 (1335-1530), 31-36 (1550-1786), 36-44 (1790-2136), 44-49 (2146-2389), 49-51 (2414-2519), 52-54 (2544-2667), 55 (2671-2711), 56-57 (2718-2806), 58-63 (2823-3028), 63 (3041-3057)ATP118 (NM_014616)2 (25-48), 20 (751-772), 21 (803-823), 22 (837-860), 23 (892-905), 28 (1051-1074)BAP1 (NM_004656)1-17 (6-730)BCL9 (NM_004326)8 (378-411), 8 (438-476), 8 (497-530), 8 (924-963), 10 (1338-1379)BIRC2 (NM_001166)2 (133-156), 2 (253-290), 3 (299-313), 6 (397-425), 7 (456-473), 9 (555-565), 9 (583-606)BIRC3 (NM_001165)9 (574-596)BRAF* (NM_004333)11 (439-4 78), 15 (581-611)BRCA1 (NM_007294)2-7 (1-183), 8-23 (191-1864)BRCA2 (NM_000059)2-4 (1-137), 5-6 (149-164), 7-11 (173-851).11 (882-1263), 11 (1305-1816), 11 (1843-2135), 11 (2142-2281), 12 (2285-2313). 13-14 (2319-2479), 15 (2487-2539), 16-27 (2548-3419)BTK (NM_000061)15 (457-498)CBL (NM_005188)8-9 (366-432)CCND1 (NM_053056)2 (88-123). 3 (139-173)CCNE1 (NM_001238)4 (45-60), 6 (109-137), 8 (204-217), 9 (268-280), 10 (298-318), 11 (339-370)CD274 (NM_014143)3 (72-111), 3 (132), 5 (228-245), 7 (284-291)CDH1* (NM_004360)1-3 (1-96). 3-16 (101-883)CDK4 (NM_000075)2 (7-50), 3 (73-101), 4 (129-162), 5-6 (190-225), 7 (228-235), 7 (267-273). 8 (286-304)CDKN2A* (NM_000077)1-2 (1-90), 2 (98-140), 2-3 (143-157)CHEK2 (NM_007194)10 (337-356). 11 (366-389)CSF1R* (NM_ 005211)7 (297-319), 9 (400-427), 22 (953-973)CSNK2A1 (NM_001895)7 (143-170), 9 (209-241). 12 (331-354)CTNNB1* (NM_001904)2 (1-5), 3-4 (9-152). 7 (319-351)DCUN1D1 (NM_020640)2 (5-26)DDR2 (NM_006182)5 (62-65), 5 (93-135), 8 (228-264), 12 (440-483), 13 (502-537), 14 (577-606), 15 (621-664), 17 (762-789)DNMT3A (NM_022552)14 (523-556), 16 (618-643), 18-19 (696-761), 23 (881-913)EGFR* (NM_005228)2 (49-78), 3 (96-123), 6 (210-245), 7-8 (250-320), 12 (473-500), 15 (575-601), 17 (669-687), 18 (695-726), 19-20 (729-800), 20 (807-823), 21 (826-875), 28 (1180-1211)ERBB2* (NM_004448)4 (147-171), 7-8 (277-327), 10 (383-398), 17 (661-691), 18-20 (732-797), 21 (832-882), 22 (904-909), 24 (968-990), 25 (1009-1051)ERBB3 (NM_001982)3 (87-120), 8 (292-312)ERBB4* (NM_005235)3 (136-141), 4 (167-186), 6 (225-247), 7 (254-290). 8 (295-323). 9 (333-367), 12 (437-470). 15 (580-623), 17 (649-677), 18 (694-726), 23 (919-948)ESR1 (NM_000125)5 (367-399). 7 (457-478), 8 (532-572)EZH2 (NM_004456)16 (625-649), 18 (677-704)FBXW7* (NM_033632)2-4 (1-242), 5-9 (255-473), 10 (478-509). 10-12 (522-708)FGFR1* (NM_015850)3-4 (117-148), 5 (176-205), 6-7 (230-273), 8 (329-359), 14 (641-657), 16 (681-722), 17 (727-760)FGFR2* (NM_000141)7 (250-275), 7 (296-313), 9 (362-399), 12 (546-558), 14 (635-662)FGFR3* (NM_000142)3 (79-122), 4 (131-149), 7 (247-277), 8 (348-359), 9 (367-402), 10 (423-430), 10 (468-471), 14 (631-653), 16 (690-719), 18 (771-807)FGFR4 (NM_022963)1-2 (1-47), 2-3 (80-146), 4-5 (161-216), 6 (243-280), 6 (306), 8 (353-382), 8 (412-426), 10 (467-484), 10-11 (500-515), 11-12 (540-585), 13-14 (609-649), 15 (678-710), 16 (714-747)FLT3* (NM_004119)2 (15-22), 4 (143-162), 8 (309-346), 10 (402-433), 11-12 (437-489), 14-15 (570-647), 16 (663-685), 20 (828-847), 22 (917-918)FOXL2 (NM_023067)1 (103-138)GAS6 (NM_000820)4 (104-115), 9 (281-318)GATA2 (NM_032638)4 (299-339), 5 (341-379)GATA3 (NM_001002295)2-3 (1-195), 3-6 (213-445)GNA11 (NM_002067)5 (202-219)GNAQ (NM_002072)4 (166-196), 5 (206-245)GNAS* (NM_000516)8-9 (196-240)HNF1A* (NM_000545)3 (192-221), 4 (253-282)HRAS* (NM_005343)2 (5-35), 3 (42-82)IDH1* (NM_005896)4 (53-94), 4 (101-135), 6 (174-197)IDH2 (NM_002168)4 (133-177)IFITM1 (NM_003641)1 (7-43)IFITM3 (NM_021034)1 (47-83)IL6 (NM_000600)1 (1-7), 2 (64-70), 3-4 (81-116), 4 (139-157)JAK1 (NM_002227)14 (638-663), 16 (706-743)JAK2* (NM_004972)12-13 (523-592), 14 (603-622), 16 (668-698)JAK3* (NM_000215)4 (128-140), 11 (484-508), 13 (568-580), 15 (640-682), 16 (709-733)KDR* (NM_002253)6-7 (244-291 ), 11 (471-480), 11 (482-512), 16 (757-785), 19 (872-894), 21 (961-988), 23 (1024-1048), 24 (1087-1102), 26 (1135-1156), 27 (1192-1221), 30 (1283-1310), 30 (1324-1357)KIT* (NM_000222)2 (23-71), 8 (411-433), 9 (494-514), 10-11 (525-587), 12 (592-602), 13 (627-661), 14 (664-684), 15 (714-724), 17-18 (802-858)KNSTRN (NM_033286)1 (1-41)KRAS* (NM_004985)2-3 (5-66), 4 (114-150)MAGOH (NM_002370)5 (121-147)MAP2K1 (NM_002755)2 (43-82), 3 (105-145), 6 (190-225)MAP2K2 (NM_030662)2 (31-68)MAPK1 (NM_002745)7 (307-322)MAX (NM_002382)3 (22-38), 4 (58-83)MCL1 (NM_021960)1 (1-9), 1 (135-171), 1 (182-225), 2 (247-279), 2 (301-312), 3 (335-351)MDM2 (NM_002392)7 (143-168), 11 (307-334), 11 (393-429), 11 (478-498)MDM4 (NM_002393)6 (115-122)MED12 (NM_005120)2 (34-68), 26 (1199-1227)MET* (NM_001127500)2 (65-103), 2 (134-188), 2 (266-296), 2 (339-391), 3 (401-415), 10 (797-806), 11 (816-856), 14 (981-1012), 15-16 (1080-1132), 19 (1246-1274)MLH1* (NM_000249)12 (373-415)MPL* (NM_005373)10 (501-522)MSH2 (NM_000251)1-2 (1-116), 3 (123-215), 4 (228-259), 5 (265-307), 6 (315-359), 7-12 (366-661), 13-16 (669-935)MTOR (NM_004958)30 (1456-1490), 39 (1789-1811), 40 (1872-1905), 47 (2193-2221)MYC (NM_002467)2 (11-29), 2 (69-96), 2 (113-140), 3 (268-274), 3 (297-330), 3 (357-395), 3 (436-455)MYCN (NM_005378)2 (22-51), 3 (289-317), 3 (363-406), 3 (431-463)MYD88 (NM_002468)3-4 (203-247), 5 (259-282)MY018A (NM_078471)8 (598-610), 22 (1173-1212), 23 (1226-1258), 26 (1331-1360), 30 (1510-1549), 34 (1712-1729)NF1 (NM_001042492)1-4 (1-160), 5-15 (174-567), 16 (574-596), 17-23 (616-1038), 25-32 (1071-1444), 33-41 (1447-2049), 42-48 (2052-2389), 49-58 (2397-2840)NF2 (NM_000268)1-16 (1-596)NFE2L2 (NM_006164)2 (16-43), 2 (52-91)NKX2-1 (NM_003317)1 (1-10)NKX2-8 (NM_014360)2 (68-105)NOTCH1* (NM_017617)2-4 (21-243), 5-9 (248-519), 10-11 (526-593), 11-13 (608-713), 14-15 (736-821), 16-19 (823-1057), 20 (1065-1107), 21-26 (1109-1602), 26-27 (1643-1680), 27-28 (1686-1769), 29-31 (1795-1970), 32-34 (1979-2116), 34 (2172-2210), 34 (2249-2556)NPM1* (NM_002520)11 (283-295)NRAS* (NM_002524)2 (3-31), 3 (43-69), 4 (112-150)PAX5 (NM_016734)3 (71-99)PDGFRA* (NM_006206)3 (21-48), 7 (311-328), 12 (552-583), 14 (644-668), 15-16 (671-755), 18 (819-854)PIK3CA* (NM_006218)2-3 (22-138), 5 (316-351), 6 (354-378), 7-8 (390-422), 8 (449-468), 10 (522-555), 14 (677-729), 19 (898-924), 20 (929-952), 21 (990-1051), 21 (1065-1069)PIK3R1 (NM_ 181523)2-10 (1-433), 11-16 (440-725)PNP (NM_000270)2 (15-37), 4 (96-108), 4 (142-154), 5-6 (190-233)PPARG (NM_015869)1 (1-28), 2 (54-91), 3 (104-123), 6 (312-353), 7 (424-453), 7 (473-506)PPP2R1A (NM_014225)5 (171-198), 6 (230-269)PTCH1 (NM_000264)1-23 (50-1448)PTEN* (NM_000314)1-7 (1-267), 8 (282-300), 8-9 (303-382)PTPN11* (NM_002834)3 (46-82), 12 (460-483), 13 (485-527)RAC1 (NM_006908)2 (18-36)RAF1 (NM_002880)7 (245-274)RB1* (NM_000321)1 (1-7), 2-4 (46-159), 5-6 (167-194), 6-12 (196-399), 13-14 (406-463), 17-18 (500-582), 18-21 (587-736), 22-24 (743-835), 25-27 (841-929)RET* (NM_020975)10-11 (608-654), 13 (762-786), 15-16 (875-924)RHEB (NM_005614)2 (21-42)RHOA (NM_001664)2 (24-52)RPS6KB1 (NM_003161)2 (54-64), 5 (130-152), 8 (230-235), 9 (260-274), 10 (307-326), 14 (410-416), 15 (482-521)SF3B1 (NM_012433)14 (611-643), 14 (649-679), 15 (693-721), 16 (763-790)SMAD4* (NM_005359)3 (98-136), 4 (142-146), 5 (165-202), 6 (242-263), 8 (307-319), 9 (326-365), 10 (384-424), 11 (443-474), 12 (494-532)SMARCB1* (NM_003073)2 (32-72), 3-5 (78-206), 6-9 (210-386)SMO* (NM_005631)3 (186-228), 5 (307-369), 6 (391-419), 9 (511-542), 11 (608-646)SOX2 (NM_003106)1 (85-114), 1 (165-210), 1 (226-268), 1 (295-692)SPOP (NM_003563)6(118-152)SRC* (NM_005417)12 (386-418), 14 (499-533)STAT3 (NM_ 139276)21 (631-673)STK11* (NM_000455)1-3 (1-137), 4-6 (155-285), 7-8 (288-361), 9 (370-389), 9 (404-434)TERT (NM_ 198253)2 (233-263), 10 (861-865), 11 (947-948)TET2 (NM_001127208)3-11 (1-2003)TIAF1 (NM_004740)1 (3-44), 1 (111-227)TP53* (NM_000546)2-11 (1-394)TSC1 (NM_000368)3-23 (1-1165)TSC2 (NM_000548)2-13 (1-454), 14-19 (473-654), 19-32 (691-1287), 33 (1295-1298), 33-42 (1324-1808)U2AF1 (NM_006758)2 (17-44), 6 (139-161)VHL* (NM_000551)1 (1-66), 1 (78-108), 2-3 (114-174), 3 (178-214)WT1 (NM_024426)1 (40-72), 1-10 (140-518)XP01 (NM_003400)15 (554-575)ZNF217 (NM_006526)1 (42-73), 1 (448-456), 3 (569-606), 4 (1031-1049)

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