An essential component in many manufactured chemicals, dyes, and naturally occurring bioactive alkaloids, 2,2-disubstituted indolin-3-ones emerged as an exciting synthetic target. Much attention has been paid to accessing this unit, particularly in an asymmetric fashion, during the last decade. In this review article, we discuss the current scenario of available methods with existing mechanistic situations to access chiral indolin-3-one derivatives under the circumstances of various catalytic systems. This overall presentation of asymmetric catalytic protocols to access 2,2-disubstituted or fused indolin-3-ones with the aza-quaternary centre is categorized based on the modes of reaction of 2-substituted-3H-indole-3-one derivatives or other similar protocols.

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