Authors Keywords: polycystic ovary syndrome, Bisphenol A, endocrine disruptors, abortion Abstract

Background. Bisphenol A (BPA) is a widely used industrial element. Recently it is suspected that BPA may disrupt the endocrine system to influence the manifestations of polycystic ovary syndrome (PCOS).

Objective. This study aimed to assess serum BPA level and its association with manifestations of PCOS in women.

Methodology. This cross-sectional study included 40 young adults with PCOS and 38 age-matched control women [23.0 (20.0, 29.0) vs. 25.0 (21.0, 29.0), years, median (IQR), p = 0.406]. After a thorough clinical examination, fasting blood was collected in the follicular phase of the menstrual cycle to measure glucose, lipids, insulin, luteinizing hormone, follicle-stimulating hormone, total testosterone, sex hormone binding globulin, dehydroepiandrosterone sulfate, and BPA. Glucose was measured by glucose oxidase, lipids by glycerol phosphate dehydrogenase-peroxidase, all hormones including SHBG by chemiluminescent immunoassay and BPA by sandwiched enzyme-linked immunosorbent assay. Insulin resistance was measured using homeostasis model assessment of insulin resistance.

Result. Women with PCOS had significantly higher BPA levels (ng/mL) than the control group [27.30 (25.60, 33.40) vs. 24.0 (15.58, 28.70), median (IQR), p = 0.001]. Using the 75th percentile value of the control group, 15 (37.5%) women with PCOS had high BPA levels. Those with high BPA levels had a significantly higher frequency of menstrual regulation /abortion among women with PCOS [53.8% vs. 0%, p=0.005]. Women with PCOS with a history of menstrual regulation / abortion [36.7 ± 4.9 vs. 28.5 ± 6.4, mean ± SD, p = 0.004] and subfertility [34.3 ± 6.8 vs. 28.5 ± 6.4, mean ± SD, p = 0.031] had higher levels of BPA than those without the histories. Serum BPA had no significant association or correlation with any androgenic and metabolic manifestations.

Conclusion. Raised BPA level may be associated with adverse reproductive features in PCOS.

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Author Biographies Dr. Emran-Ur-Rashid Chowdhury, Bangabandhu Sheikh Mujib Medical University Dr. Hurjahan Banu, Bangabandhu Sheikh Mujib Medical University

Assistant Professor and PhD Researcher

Dr. Iffat Ara Jahan, Bangabandhu Sheikh Mujib Medical University Dr. Subi Kharel, Bangabandhu Sheikh Mujib Medical University Prof. M A Hasanat, Bangabandhu Sheikh Mujib Medical University How to Cite

Chowdhury, E.-U.-R., Banu, H., Shahed-Morshed, M., Jahan, I. A., Kharel, S., & Hasanat, M. A. (2025). Raised Bisphenol A has a Significant Association with Adverse Reproductive Manifestations rather than Biochemical or Hormonal Aberrations in Women with Polycystic Ovary Syndrome . Journal of the ASEAN Federation of Endocrine Societies. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/4905

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