Abbreviated Duration of Vasoactive Agents Has Similar Outcomes as Standard Duration of Therapy in Patients with Liver Cirrhosis and Variceal Bleeding: An Individual Patient Data Meta-Analysis

D’Amico G, Bernardi M, Angeli P. Towards a new definition of decompensated cirrhosis. J Hepatol. 2022;76:202–207.

Article  PubMed  Google Scholar 

Wells M, Chande N, Adams P, Beaton M, Levstik M, Boyce E et al. Meta-analysis: vasoactive medications for the management of acute variceal bleeds. Aliment Pharmacol Ther. 2012;35:1267–1278.

Article  CAS  PubMed  Google Scholar 

de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Abraldes JG et al. Baveno VII – Renewing consensus in portal hypertension. Journal of Hepatology. 2022;76:959–974.

Article  PubMed  Google Scholar 

Garcia-Tsao G, Abraldes JG, Rich NE, Wong VW-S. AGA Clinical Practice Update on the Use of Vasoactive Drugs and Intravenous Albumin in Cirrhosis: Expert Review. Gastroenterology. 2024;166:202–10.

Vaishnav M, Biswas S, Shenoy A, Pathak P, Anand A, Swaroop S et al. Comparison of 1-day versus 3-day intravenous terlipressin in cirrhosis patients with variceal bleeding: A pilot randomised controlled trial. Aliment Pharmacol Ther. 2024;59:645–655.

Article  CAS  PubMed  Google Scholar 

Lo G-H, Yeh J-H, Tseng C-H, Chen T-H, Tai C-M, Wang W-L, et al. A non-inferiority trial comparing 2 days vs. 5 days of terlipressin and ceftriaxone in terms of 5-day rebleeding for patients with acute gastro-esophageal variceal hemorrhage. Am J Gastroenterol. 2024; 119(9):1821–1830.

Lo G-H, Perng D-S, Chang C-Y, Tai C-M, Wang H-M, Lin H-C. Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding. J Gastroenterol Hepatol. 2013;28:684–689.

Article  CAS  PubMed  Google Scholar 

Azam Z, Hamid S, Jafri W, Salih M, Abbas Z, Abid S et al. Short course adjuvant terlipressin in acute variceal bleeding: A randomized double blind dummy controlled trial. J Hepatol. 2012;56:819–824.

Article  CAS  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

Article  PubMed  PubMed Central  Google Scholar 

Salim A, Malik K, ul Haq I, Butt AK, Alam A. Comparison of 12-hour with 72-hour Terlipressin therapy for bleeding esophageal varices. J Coll Phys Surg Pak. 2017;27:334–7.

Zaman M, Zaidi AR, Hyder A, Kumar M, Amin J, Malik K. Frequency of rebleeding between short course terlipressin different courses (24 hours) and usual course (72 hours) terlipressin in adult cirrhotic patients presenting with acute variceal rebleeding. Med Forum Monthly. 2019;30:130–133.

Google Scholar 

Poudel RC, Dhibar DP, Sharma N, Sharma V, Taneja S, Prakash A. Rational for continuing terlipressin after endoscopic variceal ligation in acute variceal haemorrhage needs further evidence: a pilot study. Arq Gastroenterol. 2022;59:89–96.

Article  PubMed  Google Scholar 

Rengasamy S, Ali SM, Sistla SC, Lakshmi CP, Harichandra Kumar KT. Comparison of 2 days versus 5 days of octreotide infusion along with endoscopic therapy in preventing early rebleed from esophageal varices: a randomized clinical study. Eur J Gastroenterol Hepatol. 2015;27:386–392.

Article  CAS  PubMed  Google Scholar 

Sung JJ, Chung SC, Yung MY, Lai CW, Lau JY, Lee YT et al. Prospective randomised study of effect of octreotide on rebleeding from oesophageal varices after endoscopic ligation. Lancet. 1995;346:1666–1669.

Article  CAS  PubMed  Google Scholar 

Abdelghani YA, Yehia R. Continuing Somatostatin Does Not Prevent Rebleeding After Variceal Ligation For Acute Variceal Bleeding. J Pharm Negat Results. 2022;13:477–482.

Article  CAS  Google Scholar 

Kumar A, Jha SK, Mittal VV, Sharma P, Sharma BC, Sarin SK. Addition of Somatostatin After Successful Endoscopic Variceal Ligation Does not Prevent Early Rebleeding in Comparison to Placebo: A Double Blind Randomized Controlled Trial. J Clin Exp Hepatol. 2015;5:204–212.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

Article  PubMed  Google Scholar 

Burke DL, Ensor J, Riley RD. Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ. Stat Med. 2017;36:855–875.

Article  PubMed  Google Scholar 

Riley RD, Ensor J, Hattle M, Papadimitropoulou K, Morris TP. Two-stage or not two-stage? That is the question for IPD meta-analysis projects. Res Synth Methods. 2023;14:903–910.

Article  PubMed  PubMed Central  Google Scholar 

Thorlund K, Engstrøm J, Wetterslev J, Imberger G, Gluud C. Trial Sequential Analysis (TSA). 2011;

Chitapanarux T, Ritdamrongthum P, Leerapun A, Pisespongsa P, Thongsawat S. Three-day versus five-day somatostatin infusion combination with endoscopic variceal ligation in the prevention of early rebleeding following acute variceal hemorrhage: A randomized controlled trial. Hepatol Res. 2015;45:1276–1282.

Article  CAS  PubMed  Google Scholar 

Calès P, Masliah C, Bernard B, Garnier P-P, Silvain C, Szostak-Talbodec N et al. Early administration of vapreotide for variceal bleeding in patients with cirrhosis. New Engl J Med. 2001;344:23–28.

Article  PubMed  Google Scholar 

Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis. Ann Intern Med. 1995;123:280–287.

Article  CAS  PubMed  Google Scholar 

Villanueva C, Piqueras M, Aracil C, Gómez C, López-Balaguer JM, Gonzalez B et al. A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding. J Hepatol. 2006;45:560–567.

Article  PubMed  Google Scholar 

García-Pagán JC, Caca K, Bureau C, Laleman W, Appenrodt B, Luca A et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. New Engl J Med. 2010;362:2370–2379.

Article  PubMed  Google Scholar 

Balcar L, Mandorfer M, Hernández-Gea V, Procopet B, Meyer EL, Giráldez Á et al. Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding. J Hepatol. 2024;80:73–81.

Article  CAS  PubMed  Google Scholar 

Lv Y, Bai W, Zhu X, Xue H, Zhao J, Zhuge Y et al. Development and validation of a prognostic score to identify the optimal candidate for preemptive TIPS in patients with cirrhosis and acute variceal bleeding. Hepatology. 2024;79:118–134.

Article  PubMed  Google Scholar 

Bowden J, Tierney JF, Simmonds M, Copas AJ, Higgins JP. Individual patient data meta-analysis of time-to-event outcomes: one-stage versus two-stage approaches for estimating the hazard ratio under a random effects model. Res Synth Methods. 2011;2:150–162.

Article  PubMed  Google Scholar 

Nicoară-Farcău O, Han G, Rudler M, Angrisani D, Monescillo A, Torres F, et al. Pre-emptive TIPS in high-risk acute variceal bleeding. An updated and revised individual patient data meta-analysis. Hepatology. 2024;79:624–35.

留言 (0)

沒有登入
gif