Harrison LB, Franzese F, Gaynor JJ, et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in the management of completely resected soft tissue sarcomas of the extremity and superficial trunk. Int J Radiat Oncol Biol Phys. 1993;27:259–65.

Article  CAS  PubMed  Google Scholar 

Rosenberg SA, Tepper J, Glatstein E, et al. The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg. 1982;196:305–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang JC, Chang AE, Baker AR, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16:197–203.

Article  CAS  PubMed  Google Scholar 

Riedel RF. Systemic therapy for advanced soft tissue sarcomas: highlighting novel therapies and treatment approaches. Cancer. 2012;118:1474–85.

Article  PubMed  Google Scholar 

van der Graaf WT, Gelderblom H. New systemic therapy options for advanced sarcomas. Curr Treat Options Oncol. 2012;13:306–17.

Article  PubMed  PubMed Central  Google Scholar 

Davis AM, O’Sullivan B, Turcotte R, et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol. 2005;75:48–53.

Article  PubMed  Google Scholar 

O’Sullivan B, Davis AM, Turcotte R, et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet. 2002;359:2235–41.

Article  PubMed  Google Scholar 

Koseła-Paterczyk H, Szacht M, Morysiński T, ługowska I, Dziewirski W, Falkowski S, Zdzienicki M, Pieńkowski A, Szamotulska K, Switaj T, Rutkowski P. Preoperative hypofractionated radiotherapy inthe treatment of localized soft tissue sarcomas. Eur J Surg Oncol. 2014;40(12):1641–7. https://doi.org/10.1016/j.ejso.2014.05.016

Pennington JD, Eilber FC, Eilber FR, Singh AS, Reed JP, Chmielowski B, et al. Long-term Outcomes With Ifosfamide-based Hypofractionated Preoperative Chemoradiotherapy for Extremity Soft Tissue Sarcomas. Am J Clin Oncol. 2018;41(12):1154–1161.

Kalbasi A, Kamrava M, Chu FI, Telesca D, Van Dams R, Yang Y, et al. A Phase II Trial of 5-Day Neoadjuvant Radiotherapy for Patients with High-Risk Primary Soft Tissue Sarcoma. Clin Cancer Res. 2020;26(8):1829–1836

Parsai S, Lawrenz J, Kilpatrick S, et al. Early outcomes of Preoperative 5-Fraction Radiation Therapy for Soft tissue sarcoma followed by Immediate Surgical Resection. Adv Radiat Oncol. 2020;5:1274–9.

Article  PubMed  PubMed Central  Google Scholar 

Bedi M, Singh R, Charlson JA, et al. Is 5 the New 25? Long-term oncologic outcomes from a phase II, prospective, 5-Fraction Preoperative Radiation Therapy Trial in patients with localized soft tissue sarcoma. Adv Radiat Oncol. 2022;7:100850.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guadagnolo BA, Bassett RL, Mitra D, et al. Hypofractionated, 3-week, preoperative radiotherapy for patients with soft tissue sarcomas (HYPORT-STS): a single-centre, open-label, single-arm, phase 2 trial. Lancet Oncol. 2022;23:1547–57.

Article  PubMed  PubMed Central  Google Scholar 

Ahmed SK, Petersen IA, Grams MP, et al. Spatially fractionated Radiation Therapy in Sarcomas: a large single-Institution experience. Adv Radiat Oncol. 2024;9:101401.

Article  CAS  PubMed  Google Scholar 

Bishop AJ, Mitra D, Farooqi A et al. Moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas (HYPORT-STS): updated local control, late toxicities, and patient-reported outcomes. Cancer. 2025;131(1):e35542

Mills M, Miller J, Liveringhouse C, et al. Novel postoperative Hypofractionated Accelerated Radiation Dose-Painting Approach for Soft tissue sarcoma. Adv Radiat Oncol. 2024;9:101391.

Article  CAS  PubMed  Google Scholar 

Pitson G, Robinson P, Wilke D, et al. Radiation response: an additional unique signature of myxoid liposarcoma. Int J Radiat Oncol Biol Phys. 2004;60:522–6.

Article  PubMed  Google Scholar 

Betgen A, Haas RL, Sonke JJ. Volume changes in soft tissue sarcomas during preoperative radiotherapy of extremities evaluated using cone-beam CT. J Radiat Oncol. 2013;2:55–62.

Article  PubMed  PubMed Central  Google Scholar 

de Vreeze RS, de Jong D, Haas RL, et al. Effectiveness of radiotherapy in myxoid sarcomas is associated with a dense vascular pattern. Int J Radiat Oncol Biol Phys. 2008;72:1480–7.

Article  PubMed  Google Scholar 

Moreau LC, Turcotte R, Ferguson P, et al. Myxoid\round cell liposarcoma (MRCLS) revisited: an analysis of 418 primarily managed cases. Ann Surg Oncol. 2012;19:1081–8.

Article  PubMed  Google Scholar 

Guadagnolo BA, Zagars GK, Ballo MT, et al. Excellent local control rates and distinctive patterns of failure in myxoid liposarcoma treated with conservation surgery and radiotherapy. Int J Radiat Oncol Biol Phys. 2008;70:760–5.

Article  PubMed  Google Scholar 

Lansu J, Bovee J, Braam P, et al. Dose reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: a Nonrandomized Controlled Trial. JAMA Oncol. 2021;7:e205865.

Article  PubMed  Google Scholar 

Kepka L, DeLaney TF, Suit HD, et al. Results of radiation therapy for unresected soft-tissue sarcomas. Int J Radiat Oncol Biol Phys. 2005;63:852–9.

Article  PubMed  Google Scholar 

Bryant JM, Mills MN, Yang GQ, et al. Novel definitive Hypofractionated Accelerated Radiation dose-painting (HARD) for Unresected Soft tissue sarcomas. Adv Radiat Oncol. 2024;9:101447.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boyce-Fappiano D, Damron EP, Farooqi A, et al. Hypofractionated Radiation Therapy for Unresectable or metastatic sarcoma lesions. Adv Radiat Oncol. 2022;7:100913.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bryant JM, Mills MN, Liveringhouse C et al. Hypofractionated accelerated radiation dose-painting (HARD) improves outcomes in unresected soft-tissue sarcoma. Radiother Oncol. 2024;5(202):110644.

Kaiser A, Mohiuddin M, Jackson G. Dramatic response from neoadjuvant, spatially fractionated GRID radiotherapy (SFGRT) for large, high-grade extremity sarcoma. J Radiation Oncol. 2013;2:103–6.

Article  Google Scholar 

Kudrimoti M, Mohiuddin M, Ahmed MM et al. Use of high dose spatially fractionated radiation (GRID therapy) in management of large, poor prognostic stage III (> 10cms) soft tissue sarcomas. Int J Radiat Oncol Biol Phys 60, 2004.

Snider JW, Molitoris J, Shyu S, et al. Spatially fractionated Radiotherapy (GRID) prior to Standard Neoadjuvant conventionally fractionated Radiotherapy for Bulky, High-Risk Soft tissue and Osteosarcomas: feasibility, Safety, and Promising Pathologic Response Rates. Radiat Res. 2020;194:707–14.

Article  CAS  PubMed  Google Scholar 

Huhn JL, Regine WF, Valentino JP, et al. Spatially fractionated GRID radiation treatment of advanced neck disease associated with head and neck cancer. Technol Cancer Res Treat. 2006;5:607–12.

Article  PubMed  Google Scholar 

Penagaricano JA, Moros EG, Ratanatharathorn V, et al. Evaluation of spatially fractionated radiotherapy (GRID) and definitive chemoradiotherapy with curative intent for locally advanced squamous cell carcinoma of the head and neck: initial response rates and toxicity. Int J Radiat Oncol Biol Phys. 2010;76:1369–75.

Article  PubMed  Google Scholar 

Sathishkumar S, Dey S, Meigooni AS, et al. The impact of TNF-alpha induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiation. Technol Cancer Res Treat. 2002;1:141–7.

Article  CAS  PubMed  Google Scholar 

Yan W, Khan MK, Wu X, et al. Spatially fractionated radiation therapy: history, present and the future. Clin Transl Radiat Oncol. 2020;20:30–8.

PubMed  Google Scholar 

Rhomberg W, Hassenstein EO, Gefeller D. Radiotherapy vs. radiotherapy and razoxane in the treatment of soft tissue sarcomas: final results of a randomized study. Int J Radiat Oncol Biol Phys. 1996;36:1077–84.

Article  CAS  PubMed  Google Scholar 

Allignet B, Sunyach MP, Geets X, et al. Is there a place for definitive radiotherapy in the treatment of unresectable soft-tissue sarcoma? A systematic review. Acta Oncol. 2022;61:720–9.

Article  CAS  PubMed  Google Scholar 

Weber DC, Rutz HP, Bolsi A, et al. Spot scanning proton therapy in the curative treatment of adult patients with sarcoma: the Paul Scherrer institute experience. Int J Radiat Oncol Biol Phys. 2007;69:865–71.

Article  PubMed  Google Scholar 

Laughlin BS, Golafshar MA, Ahmed S, et al. Early experience using Proton Beam Therapy for Extremity Soft tissue sarcoma: a Multicenter Study. Int J Part Ther. 2022;9:1–11.

Article  PubMed