Tetramethylpyrazine promotes osteo-angiogenesis during bone fracture repair

Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, et al. Cellular biology of fracture healing. J Orthop Res. 2019;37(1):35–50.

Article  PubMed  Google Scholar 

Khanna A, Gougoulias N, Maffulli N. Intermittent pneumatic compression in fracture and soft-tissue injuries healing. Br Med Bull. 2008;88(1):147–56.

Article  PubMed  Google Scholar 

Antonova E, Le TK, Burge R, Mershon J. Tibia shaft fractures: costly burden of nonunions. BMC Musculoskelet Disord. 2013;14:42.

Article  PubMed  PubMed Central  Google Scholar 

Migliorini F, Cocconi F, Vecchio G, Schäefer L, Koettnitz J, Maffulli N. Pharmacological agents for bone fracture healing: talking points from recent clinical trials. Expert Opin Investig Drugs. 2023;32(9):855–65.

Article  CAS  PubMed  Google Scholar 

Dimitriou R, Mataliotakis GI, Angoules AG, Kanakaris NK, Giannoudis PV. Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review. Injury. 2011;42(Suppl 2):S3–15.

Article  PubMed  Google Scholar 

Huang SC, Wang M, Wu WB, Wang R, Cui J, Li W et al. Mir-22-3p Inhibits Arterial Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia by Targeting HMGB1 in Arteriosclerosis Obliterans. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017;42(6):2492–506.

Einhorn TA, Gerstenfeld LC. Fracture healing: mechanisms and interventions. Nat Rev Rheumatol. 2015;11(1):45–54.

Article  PubMed  Google Scholar 

Martinez de Albornoz P, Khanna A, Longo UG, Forriol F, Maffulli N. The evidence of low-intensity pulsed ultrasound for in vitro, animal and human fracture healing. Br Med Bull. 2011;100:39–57.

Article  PubMed  Google Scholar 

Melincovici CS, Boşca AB, Şuşman S, Mărginean M, Mihu C, Istrate M, et al. Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 2018;59(2):455–67.

PubMed  Google Scholar 

Ramasamy SK, Kusumbe AP, Schiller M, Zeuschner D, Bixel MG, Milia C, et al. Blood flow controls bone vascular function and osteogenesis. Nat Commun. 2016;7:13601.

Article  PubMed  PubMed Central  Google Scholar 

Chen Z, Zhang C, Gao F, Fu Q, Fu C, He Y, et al. A systematic review on the rhizome of Ligusticum chuanxiong Hort. (Chuanxiong). Food Chem Toxicol. 2018;119:309–25.

Article  CAS  PubMed  Google Scholar 

Dong XL, Yu WX, Li CM, Zhou LP, Wong MS. Chuanxiong (Rhizome of Ligusticum chuanxiong) Protects Ovariectomized Hyperlipidemic Rats from Bone Loss. Am J Chin Med. 2020;48(2):463–85.

Article  CAS  PubMed  Google Scholar 

Wang MY, An MF, Fan MS, Zhang SS, Sun ZR, Zhao YL, et al. FAEE exerts a protective effect against osteoporosis by regulating the MAPK signalling pathway. Pharm Biol. 2022;60(1):467–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Liu Y, Chen K. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638.

Article  PubMed  PubMed Central  Google Scholar 

Dhaliwal J, Dhaliwal N, Akhtar A, Kuhad A, Chopra K. Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats. Neurochem Res. 2022;47(8):2431–44.

Article  CAS  PubMed  Google Scholar 

Li J, Gong X. Tetramethylpyrazine: An Active Ingredient of Chinese Herbal Medicine With Therapeutic Potential in Acute Kidney Injury and Renal Fibrosis. Front Pharmacol. 2022;13:820071.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan J, Xiang D, Luo H, Wang G, Ye Y, Yu C, et al. Tetramethylpyrazine suppresses lipid accumulation in macrophages via upregulation of the ATP-binding cassette transporters and downregulation of scavenger receptors. Oncol Rep. 2017;38(4):2267–76.

Article  CAS  PubMed  Google Scholar 

Cai X, Chen Z, Pan X, Xia L, Chen P, Yang Y, et al. Inhibition of angiogenesis, fibrosis and thrombosis by tetramethylpyrazine: mechanisms contributing to the SDF-1/CXCR4 axis. PLoS ONE. 2014;9(2):e88176.

Article  PubMed  PubMed Central  Google Scholar 

Chen H, Cao J, Zhu Z, Zhang G, Shan L, Yu P, et al. A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways. Front Neurosci. 2018;12:567.

Article  PubMed  PubMed Central  Google Scholar 

Lu C, Zhang J, Shi X, Miao S, Bi L, Zhang S, et al. Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson’s disease induced by MPTP. Int J Biol Sci. 2014;10(4):350–7.

Article  PubMed  PubMed Central  Google Scholar 

Wang C, Li Y, Yang X, Bi S, Zhang Y, Han D, et al. Tetramethylpyrazine and Astragaloside IV Synergistically Ameliorate Left Ventricular Remodeling and Preserve Cardiac Function in a Rat Myocardial Infarction Model. J Cardiovasc Pharmacol. 2017;69(1):34–40.

Article  CAS  PubMed  Google Scholar 

Wang L, Lu WG, Shi J, Zhang HY, Xu XL, Gao B, et al. Anti–osteoporotic effects of tetramethylpyrazine via promoting osteogenic differentiation and inhibiting osteoclast formation. Mol Med Rep. 2017;16(6):8307–14.

Article  CAS  PubMed  Google Scholar 

Jiang Y, Liu C, Chen W, Wang H, Wang C, Lin N. Tetramethylpyrazine enhances vascularization and prevents osteonecrosis in steroid-treated rats. Biomed Res Int. 2015;2015:315850.

Article  PubMed  PubMed Central  Google Scholar 

Mehmood K, Zhang H, Li K, Wang L, Rehman MU, Nabi F, et al. Effect of tetramethylpyrazine on tibial dyschondroplasia incidence, tibial angiogenesis, performance and characteristics via HIF-1α/VEGF signaling pathway in chickens. Sci Rep. 2018;8(1):2495.

Article  PubMed  PubMed Central  Google Scholar 

Zhang M, Gao F, Teng F, Zhang C. Tetramethylpyrazine promotes the proliferation and migration of brain endothelial cells. Mol Med Rep. 2014;10(1):29–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang C, Xu Y, Mendez T, Wang F, Yang Q, Li S. Effects of intravenous urocortin on angiotensin-converting enzyme in rats. Vascul Pharmacol. 2006;44(4):238–46.

Article  PubMed  Google Scholar 

Yalçınozan M, Türker M, Çırpar M. Effects of a novel biodegredable implant system on a rat tibia fracture model. Acta Orthop Traumatol Turc. 2020;54(4):453–60.

Article  PubMed  PubMed Central  Google Scholar 

Huang C, Ness VP, Yang X, Chen H, Luo J, Brown EB, et al. Spatiotemporal Analyses of Osteogenesis and Angiogenesis via Intravital Imaging in Cranial Bone Defect Repair. J Bone Min Res. 2015;30(7):1217–30.

Article  CAS  Google Scholar 

Ding L, Gu S, Zhou B, Wang M, Zhang Y, Wu S, et al. Ginsenoside Compound K Enhances Fracture Healing via Promoting Osteogenesis and Angiogenesis. Front Pharmacol. 2022;13:855393.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiu P, Li M, Chen K, Fang B, Chen P, Tang Z, et al. Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis. Biomaterials. 2020;227:119552.

Article  CAS  PubMed  Google Scholar 

Chim SM, Qin A, Tickner J, Pavlos N, Davey T, Wang H, et al. EGFL6 promotes endothelial cell migration and angiogenesis through the activation of extracellular signal-regulated kinase. J Biol Chem. 2011;286(25):22035–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Street J, Bao M, deGuzman L, Bunting S, Peale FV Jr., Ferrara N, et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A. 2002;99(15):9656–61.

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