Effects of radiotherapy on the hippocampus and hippocampal neurogenesis: a systematic review of preclinical studies

Toda T, Parylak SL, Linker SB, Gage FH (2019) The role of adult hippocampal neurogenesis in brain health and disease. Mol Psychiatry 24:67–87. https://doi.org/10.1038/s41380-018-0036-2

Article  PubMed  Google Scholar 

Surget A, Belzung C (2022) Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective. Mol Psychiatry 27:403–421. https://doi.org/10.1038/s41380-021-01136-8

Article  PubMed  Google Scholar 

Mineyeva OA, Bezriadnov DV, Kedrov AV, Lazutkin AA, Anokhin KV, Enikolopov GN (2018) Radiation induces distinct changes in defined Subpopulations of neural stem and progenitor cells in the adult hippocampus. Front Neurosci 12:1013. https://doi.org/10.3389/fnins.2018.01013

Article  PubMed  Google Scholar 

Gondi V, Tome WA, Mehta MP (2010) Why avoid the hippocampus? A comprehensive review. Radiother Oncol 97:370–376. https://doi.org/10.1016/j.radonc.2010.09.013

Article  PubMed  PubMed Central  Google Scholar 

Revell SH (1983) Relationships between chromosome damage and cell death. Radiation-induced chromosome damage in man, pp 215–233

Google Scholar 

Frey B, Borgmann K, Jost T, Greve B, Oertel M, Micke O, Eckert F (2023) DNA as the main target in radiotherapy—a historical overview from first isolation to anti-tumour immune response. Strahlenther Onkol 199:1080–1090. https://doi.org/10.1007/s00066-023-02122-5

Article  PubMed  Google Scholar 

DeAngelis LM, Delattre JY, Posner JB (1989) Radiation-induced dementia in patients cured of brain metastases. Neurology 39:789–796. https://doi.org/10.1212/wnl.39.6.789

Article  PubMed  Google Scholar 

Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu FC, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD et al (2012) Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat Res 178:46–56. https://doi.org/10.1667/rr2731.1

Article  PubMed  PubMed Central  Google Scholar 

Mulhern RK, Merchant TE, Gajjar A, Reddick WE, Kun LE (2004) Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol 5:399–408. https://doi.org/10.1016/S1470-2045(04)01507-4

Article  PubMed  Google Scholar 

Merchant TE, Schreiber JE, Wu S, Lukose R, Xiong X, Gajjar A (2014) Critical combinations of radiation dose and volume predict intelligence quotient and academic achievement scores after craniospinal irradiation in children with medulloblastoma. Int J Radiat Oncol Biol Phys 90:554–561. https://doi.org/10.1016/j.ijrobp.2014.06.058

Article  PubMed  PubMed Central  Google Scholar 

Brown PD, Jaeckle K, Ballman KV, Farace E, Cerhan JH, Anderson SK, Carrero XW, Barker FG 2nd, Deming R, Burri SH et al (2016) Effect of Radiosurgery alone vs Radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA 316:401–409. https://doi.org/10.1001/jama.2016.9839

Article  PubMed  PubMed Central  Google Scholar 

Gondi V, Pugh SL, Tome WA, Caine C, Corn B, Kanner A, Rowley H, Kundapur V, DeNittis A, Greenspoon JN et al (2014) Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol 32:3810–3816. https://doi.org/10.1200/JCO.2014.57.2909

Article  PubMed  PubMed Central  Google Scholar 

Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014) SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol 14:43. https://doi.org/10.1186/1471-2288-14-43

Article  PubMed  PubMed Central  Google Scholar 

Kuil LE, Seigers R, Loos M, de Gooijer MC, Compter A, Boogerd W, Van Tellingen O, Smit AB, Schagen SB (2022) Fractionated brain irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior and cognition in mice. https://doi.org/10.1101/2022.09.01.506166

Book  Google Scholar 

Peissner W, Kocher M, Treuer H, Gillardon F (1999) Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Res Mol Brain Res 71:61–68. https://doi.org/10.1016/s0169-328x(99)00170-9

Article  PubMed  Google Scholar 

Kuil LE, Seigers R, Loos M, de Gooijer MC, Compter A, Boogerd W, Van Tellingen O, Smit AB, Schagen SB (2024) Fractionated brain irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior and cognition in mice https://doi.org/10.1101/2022.09.01.506166

Book  Google Scholar 

Achanta P, Fuss M, Martinez JL Jr. (2009) Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesis. Behav Neurosci 123:1036–1045. https://doi.org/10.1037/a0016870

Article  PubMed  Google Scholar 

Lensu S, Waselius T, Mäkinen E, Kettunen H, Virtanen A, Tiirola M, Penttonen M, Pekkala S, Nokia MS (2021) Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats. Eur J Neurosci 53:1885–1904. https://doi.org/10.1111/ejn.15102

Article  PubMed  Google Scholar 

Balentova S, Hajtmanova E, Filova B, Borbelyova V, Lehotsky J, Adamkov M (2018) Effects of fractionated whole-brain irradiation on cellular composition and cognitive function in the rat brain. Int J Radiat Biol 94:238–247. https://doi.org/10.1080/09553002.2018.1425805

Article  PubMed  Google Scholar 

Hellström NA, Björk-Eriksson T, Blomgren K, Kuhn HG (2009) Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation. Stem Cells 27:634–641. https://doi.org/10.1634/stemcells.2008-0732

Article  PubMed  Google Scholar 

Madsen TM, Kristjansen PE, Bolwig TG, Wörtwein G (2003) Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 119:635–642. https://doi.org/10.1016/s0306-4522(03)00199-4

Article  PubMed  Google Scholar 

Rola R, Raber J, Rizk A, Otsuka S, VandenBerg SR, Morhardt DR, Fike JR (2004) Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol 188:316–330. https://doi.org/10.1016/j.expneurol.2004.05.005

Article  PubMed  Google Scholar 

Parihar VK, Acharya MM, Roa DE, Bosch O, Christie LA, Limoli CL (2014) Defining functional changes in the brain caused by targeted stereotaxic radiosurgery. Transl Cancer Res 3:124–137. https://doi.org/10.3978/j.issn.2218-676X.2013.06.02

Article  PubMed  Google Scholar 

Ji S, Ding X, Ji J, Wu H, Sun R, Li X, Zhang L, Tian Y (2018) Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A. Oncol Lett 15:2899–2904. https://doi.org/10.3892/ol.2017.7643

Article  PubMed  Google Scholar 

Son Y, Yang M, Kim JS, Kim J, Kim SH, Kim JC, Shin T, Wang H, Jo SK, Jung U et al (2014) Hippocampal dysfunction during the chronic phase following a single exposure to cranial irradiation. Exp Neurol 254:134–144. https://doi.org/10.1016/j.expneurol.2014.01.018

Article  PubMed  Google Scholar 

Schindler MK, Bourland JD, Forbes ME, Hua K, Riddle DR (2011) Neurobiological responses to stereotactic focal irradiation of the adult rodent hippocampus. J Neurol Sci 306:129–137. https://doi.org/10.1016/j.jns.2011.03.025

Article  PubMed  PubMed Central  Google Scholar 

Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S (2006) Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16:296–304. https://doi.org/10.1002/hipo.20163

Article  PubMed  Google Scholar 

Pius-Sadowska E, Kawa MP, Klos P, Roginska D, Rudnicki M, Boehlke M, Waloszczyk P, Machalinski B (2016) Alteration of selected Neurotrophic factors and their receptor expression in mouse brain response to whole-brain irradiation. Radiat Res 186:489–507. https://doi.org/10.1667/RR14457.1

Article  PubMed  Google Scholar 

Ding X, Wu HH, Ji SJ, Cai S, Dai PW, Xu ML, Zhang JJ, Zhang QX, Tian Y, Ma QH (2017) The p75 neurotrophin receptor regulates cranial irradiation-induced hippocampus-dependent cognitive dysfunction. Oncotarget 8:40544–40557. https://doi.org/10.18632/oncotarget.16492

Article  PubMed  PubMed Central  Google Scholar 

Hinzman CP, Baulch JE, Mehta KY, Gill K, Limoli CL, Cheema AK (2018) Exposure to ionizing radiation causes Endoplasmic reticulum stress in the mouse hippocampus. Radiat Res 190:483–493. https://doi.org/10.1667/RR15061.1

Article  PubMed 

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