Postprandial hypoglycaemia after gastric bypass in type 2 diabetes: pathophysiological mechanisms and clinical implications

Sjostrom L, Lindroos AK, Peltonen M et al (2004) Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351(26):2683–2693. https://doi.org/10.1056/NEJMoa035622

Article  PubMed  Google Scholar 

Schauer PR, Bhatt DL, Kirwan JP et al (2017) Bariatric surgery versus intensive medical therapy for diabetes - 5-year outcomes. N Engl J Med 376(7):641–651. https://doi.org/10.1056/NEJMoa1600869

Article  PubMed  PubMed Central  Google Scholar 

Patti ME, McMahon G, Mun EC et al (2005) Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 48(11):2236–2240. https://doi.org/10.1007/s00125-005-1933-x

Article  PubMed  Google Scholar 

Vaurs C, Brun JF, Bertrand M et al (2016) Post-prandial hypoglycemia results from a non-glucose-dependent inappropriate insulin secretion in Roux-en-Y gastric bypassed patients. Metabolism 65(3):18–26. https://doi.org/10.1016/j.metabol.2015.10.020

Article  PubMed  Google Scholar 

Marsk R, Jonas E, Rasmussen F, Naslund E (2010) Nationwide cohort study of post-gastric bypass hypoglycaemia including 5,040 patients undergoing surgery for obesity in 1986–2006 in Sweden. Diabetologia 53(11):2307–2311. https://doi.org/10.1007/s00125-010-1798-5

Article  PubMed  Google Scholar 

Pigeyre M, Vaurs C, Raverdy V, Hanaire H, Ritz P, Pattou F (2015) Increased risk of OGTT-induced hypoglycemia after gastric bypass in severely obese patients with normal glucose tolerance. Surg Obes Relat Dis 11(3):573–577. https://doi.org/10.1016/j.soard.2014.12.004

Article  PubMed  Google Scholar 

Abrahamsson N, Eden Engstrom B, Sundbom M, Karlsson FA (2015) Hypoglycemia in everyday life after gastric bypass and duodenal switch. Eur J Endocrinol 173(1):91–100. https://doi.org/10.1530/EJE-14-0821

Article  PubMed  Google Scholar 

Guarino D, Moriconi D, Mari A et al (2018) Postprandial hypoglycaemia after Roux-en-Y gastric bypass in individuals with type 2 diabetes. Diabetologia 62(1):178–186. https://doi.org/10.1007/s00125-018-4737-5

Article  PubMed  Google Scholar 

Salehi M, Woods SC, D’Alessio DA (2015) Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion. Obesity (Silver Spring) 23(10):2046–2052. https://doi.org/10.1002/oby.21186

Article  PubMed  Google Scholar 

Dirksen C, Eiken A, Bojsen-Moller KN et al (2016) No islet cell hyperfunction, but altered gut-islet regulation and postprandial hypoglycemia in glucose-tolerant patients 3 years after gastric bypass surgery. Obes Surg 26(9):2263–2267. https://doi.org/10.1007/s11695-016-2197-x

Article  PubMed  Google Scholar 

Hwang JJ, Parikh L, Lacadie C et al (2018) Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. J Clin Invest 128(4):1485–1495. https://doi.org/10.1172/JCI97696

Article  PubMed  PubMed Central  Google Scholar 

Hanefeld M, Frier BM, Pistrosch F (2016) Hypoglycemia and cardiovascular risk: is there a major link? Diabetes Care 39(Suppl 2):S205–S209. https://doi.org/10.2337/dcS15-3014

Article  PubMed  Google Scholar 

Puleio A, Sheehan A, Musen G, Patti ME (2024) Cognition in patients with post-bariatric hypoglycemia. Obesity 32(3):466–471. https://doi.org/10.1002/oby.23862

Article  PubMed  Google Scholar 

ElSayed NA, Aleppo G, Bannuru RR et al (2024) 6. Glycemic goals and hypoglycemia: Standards of Care in Diabetes—2024. Diabetes Care 47(Suppl 1):S111–S125. https://doi.org/10.2337/dc24-S006

Article  Google Scholar 

Trico D, Mengozzi A, Baldi S et al (2022) Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals. Metabolism 134:155247. https://doi.org/10.1016/j.metabol.2022.155247

Article  PubMed  Google Scholar 

Van Cauter E, Mestrez F, Sturis J, Polonsky KS (1992) Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41(3):368–377. https://doi.org/10.2337/diab.41.3.368

Article  PubMed  Google Scholar 

Mari A, Ferrannini E (2008) Beta-cell function assessment from modelling of oral tests: an effective approach. Diabetes Obes Metab 10(Suppl 4):77–87. https://doi.org/10.1111/j.1463-1326.2008.00946.x

Article  PubMed  Google Scholar 

Mengozzi A, Trico D, Nesti L et al (2020) Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and early major beta-cell function defects: a cross-sectional and longitudinal analysis of the Relationship between Insulin Sensitivity and Cardiovascular risk (RISC) study cohort. Metabolism 105:154185. https://doi.org/10.1016/j.metabol.2020.154185

Article  PubMed  Google Scholar 

Trico D, Moriconi D, Berta R et al (2021) Effects of low-carbohydrate versus mediterranean diets on weight loss, glucose metabolism, insulin kinetics and beta-cell function in morbidly obese individuals. Nutrients 13(4):1345. https://doi.org/10.3390/nu13041345

Article  PubMed  PubMed Central  Google Scholar 

Trico D, Galderisi A, Mari A, Santoro N, Caprio S (2019) One-hour post-load plasma glucose predicts progression to prediabetes in a multi-ethnic cohort of obese youths. Diabetes Obes Metab 21(5):1191–1198. https://doi.org/10.1111/dom.13640

Article  PubMed  PubMed Central  Google Scholar 

Trico D, Natali A, Mari A, Ferrannini E, Santoro N, Caprio S (2018) Triglyceride-rich very low-density lipoproteins (VLDL) are independently associated with insulin secretion in a multiethnic cohort of adolescents. Diabetes Obes Metab 20(12):2905–2910. https://doi.org/10.1111/dom.13467

Article  PubMed  PubMed Central  Google Scholar 

Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ (2001) A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24(3):539–548. https://doi.org/10.2337/diacare.24.3.539

Article  PubMed  Google Scholar 

Trico D, Mengozzi A, Frascerra S, Scozzaro MT, Mari A, Natali A (2019) Intestinal glucose absorption is a key determinant of 1-hour postload plasma glucose levels in nondiabetic subjects. J Clin Endocrinol Metab 104(6):2131–2139. https://doi.org/10.1210/jc.2018-02166

Article  PubMed  Google Scholar 

Gold AE, Macleod KM, Frier BM (1994) Frequency of severe hypoglycemia in patients with type i diabetes with impaired awareness of hypoglycemia. Diabetes Care 17(7):697–703. https://doi.org/10.2337/diacare.17.7.697

Article  PubMed  Google Scholar 

Clarke WL, Cox DJ, Gonder-Frederick LA, Julian D, Schlundt D, Polonsky W (1995) Reduced awareness of hypoglycemia in adults with IDDM: a prospective study of hypoglycemic frequency and associated symptoms. Diabetes Care 18(4):517–522. https://doi.org/10.2337/diacare.18.4.517

Article  PubMed  Google Scholar 

Deary IJ, Hepburn DA, MacLeod KM, Frier BM (1993) Partitioning the symptoms of hypoglycaemia using multi-sample confirmatory factor analysis. Diabetologia 36(8):771–777. https://doi.org/10.1007/bf00401150

Article  PubMed  Google Scholar 

Mueller ST, Piper BJ (2014) The Psychology Experiment Building Language (PEBL) and PEBL test battery. J Neurosci Methods 222:250–259. https://doi.org/10.1016/j.jneumeth.2013.10.024

Article  PubMed  Google Scholar 

Trico D, Masoni MC, Baldi S et al (2024) Early time-restricted carbohydrate consumption vs conventional dieting in type 2 diabetes: a randomised controlled trial. Diabetologia 67(2):263–274. https://doi.org/10.1007/s00125-023-06045-9

Article  PubMed  Google Scholar 

Patti ME, Li P, Goldfine AB (2015) Insulin response to oral stimuli and glucose effectiveness increased in neuroglycopenia following gastric bypass. Obesity (Silver Spring) 23(4):798–807. https://doi.org/10.1002/oby.21043

Article  PubMed  Google Scholar 

Salehi M, Gastaldelli A, D’Alessio DA (2014) Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia. J Clin Endocrinol Metab 99(6):2008–2017. https://doi.org/10.1210/jc.2013-2686

Article  PubMed  PubMed Central  Google Scholar 

Goldfine AB, Mun EC, Devine E et al (2007) Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab 92(12):4678–4685. https://doi.org/10.1210/jc.2007-0918

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