Breathing relies on unrestricted movement of the chest wall to maintain oxygen and carbon dioxide balance. Understanding the effects of chest and abdominal restrictions on respiratory function is critical for studying conditions such as respiratory diseases, extreme environments, and load-induced impairments. However, existing methods to simulate these restrictions are limited, lacking the ability to provide both static and dynamic conditions or precise load control. To address these gaps, we developed a novel chest wall and abdomen restriction device capable of independently applying and measuring static and dynamic loads with adjustable and reproducible force levels. Separate bands for the chest and abdomen enable targeted restrictions, with constant force springs providing resistance during dynamic conditions and immobilization during static conditions. Integrated sensors quantify applied loads and respiratory mechanics. To validate the device, healthy participants underwent pulmonary function testing and respiratory analysis under baseline, static restriction, and dynamic restriction conditions. Significant reductions in forced expiratory volume (FEV1) and forced vital capacity (FVC) were observed under restrictions compared to baseline. Other respiratory metrics, including inspiratory volume, inspiratory time, and peak inspiratory airflow, also showed significant differences, highlighting distinct effects of static and dynamic restrictions. Pressure variability tests confirmed the reproducibility and adjustability of applied loads, while displacement data from linear variable differential transducers (LVDTs) validated the device's ability to distinguish static and dynamic effects. This device addresses prior limitations by enabling precise, reproducible loading and independent control of chest and abdominal restrictions. Its versatility supports research into respiratory diseases, extreme environments, and respiratory mechanics. The results demonstrate the device's potential to advance respiratory function research and expand its clinical and experimental applications.
Competing Interest StatementThe authors have declared no competing interest.
Funding StatementThis work was supported by the Office of Naval Research (grant number N00014-22-1-2653).
Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Yes
The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
The study procedures were approved by the Institutional Review Board of the University of Florida.
I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.
Yes
Data AvailabilityAll data produced in the present study are available upon reasonable request to the authors.
留言 (0)