Front. Med.

Sec. Ophthalmology

Volume 11 - 2024 | doi: 10.3389/fmed.2024.1517198

Provisionally accepted

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Background To review the etiology of corneal blindness and investigate the relative risk of corneal graft rejection in the Southern Liaoning Region. Methods The clinical record information of 359 patients (394 eyes) who underwent corneal transplantation at the Department of Keratoconus of the Third People's Hospital of Dalian from January 2019 to December 2023 was retrospectively analyzed, including patients' age, gender, occupation, diagnosis, surgical procedure, postoperative immune rejection, and neovascularization. Data were collected and descriptively analyzed to characterize the etiology of corneal blindness and to analyze the risk factors for postoperative immune rejection after corneal transplantation by logistic regression in the Southern Liaoning Region. Results The mean age of corneal transplant patients was 55.90±0.80 years, and there were more male patients than female patients with corneal blindness. Infectious keratitis (41.1%) was the leading cause of corneal blindness, and penetrating corneal transplantation is the main surgical procedure for recovery of sight. Preoperative corneal vascularization and penetrating corneal graft rejection were risk factors for immune rejection of corneal grafts. When preoperative corneal vascularization was present (P=0.044, OR=2.607). Penetrating keratoplasty was performed (P=0.024, OR=1.953) and deep lamellar keratoplasty was performed (P=0.801, OR=1.088). Viral infections (P

Keywords: Corneal blindness, Keratoplasty, Corneal graft rejection, neovascularization, Virus keratitis

Received: 25 Oct 2024; Accepted: 23 Dec 2024.

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