Bethlehem L, Echten-Deckert GV (2020) Ectoines as novel anti-inflammatory and tissue protective lead compounds with special focus on inflammatory bowel disease and lung inflammation. Pharmacol Res 164(1):105389. https://doi.org/10.1016/j.phrs.2020.105389

Article  CAS  PubMed  Google Scholar 

Cai D, Wei X, Qiu Y, Chen Y, Chen J, Wen Z, Chen S (2016) High-level expression of nattokinase in Bacillus licheniformis by manipulating signal peptide and signal peptidase. J Appl Microbiol 121(3):704–712. https://doi.org/10.1111/jam.13175

Article  CAS  PubMed  Google Scholar 

Cai D, Chen Y, He P, Wang S, Mo F, Li X, Wang Q, Nomura CT, Wen Z, Ma X, Chen S (2018) Enhanced production of poly-γ-glutamic acid by improving ATP supply in metabolically engineered Bacillus licheniformis. Biotechnol Bioeng 115(10):2541–2553. https://doi.org/10.1002/bit.26774

Article  CAS  PubMed  Google Scholar 

Chen J, Qiao D, Yuan T, Feng Y, Zhang P, Wang X, Zhang L (2024) Biotechnological production of ectoine: current status and prospects. Folia Microbiol (Praha) 69(2):247–258. https://doi.org/10.1007/s12223-023-01105-4

Article  CAS  PubMed  Google Scholar 

Feng Y, Qiu M, Shao L, Jiang Y, Zhang W, Jiang W, Xin F, Jiang M (2024) Strategies for the biological production of ectoine by using different chassis strains. Biotechnol Adv 70:108306. https://doi.org/10.1016/j.biotechadv.2023.108306

Article  CAS  PubMed  Google Scholar 

Gießelmann G, Dietrich D, Jungmann L, Kohlstedt M, Jeon EJ, Yim SS, Sommer F, Zimmer D, Mühlhaus T, Schroda M, Jeong KJ, Becker J, Wittmann C (2019) Metabolic Engineering of Corynebacterium glutamicum for High-Level Ectoine production: design, Combinatorial Assembly, and implementation of a transcriptionally balanced Heterologous Ectoine Pathway. Biotechnol J 14(9):e1800417. https://doi.org/10.1002/biot.201800417

Article  CAS  PubMed  Google Scholar 

Gu Y, Deng J, Liu Y, Li J, Shin HD, Du G, Chen J, Liu L (2017) Rewiring the Glucose Transportation and central metabolic pathways for overproduction of N-Acetylglucosamine in Bacillus subtilis. Biotechnol J 12(10). https://doi.org/10.1002/biot.201700020

Hahn MB, Smales GJ, Seitz H, Solomun T, Sturm H (2020) Ectoine interaction with DNA: influence on ultraviolet radiation damage. Phys Chem Chem Phys 22(13):6984–6992. https://doi.org/10.1039/d0cp00092b

Article  CAS  PubMed  Google Scholar 

He H, Zhang Y, Shi G, Li Y (2023) Recent biotechnological advances and future prospective of Bacillus licheniformis as microbial cell factories. SMAB 3(4):521–532. https://doi.org/10.1007/s43393-023-00162-7

Article  CAS  Google Scholar 

Hobmeier K, Oppermann M, Stasinski N, Kremling A, Pflüger-Grau K, Kunte HJ, Marin-Sanguino A (2022) Metabolic engineering of Halomonas elongata: ectoine secretion is increased by demand and supply driven approaches. Front Microbiol 13:968983. https://doi.org/10.3389/fmicb.2022.968983

Article  PubMed  PubMed Central  Google Scholar 

Hu S, He P, Zhang Y, Jiang M, Wang Q, Yang S, Chen S (2022) Transcription factor DegU-mediated multi-pathway regulation on lichenysin biosynthesis in Bacillus licheniformis. Metab Eng 74:108–120. https://doi.org/10.1016/j.ymben.2022.10.003

Article  CAS  PubMed  Google Scholar 

Hu S, Zhao C, Zhang Y, Wang X, He P, Chen S (2023) Construct a synthetic entner-doudoroff pathway in Bacillus licheniformis for enhancing lichenysin production. World J Microbiol Biotechnol 39(7):168. https://doi.org/10.1007/s11274-023-03619-y

Article  CAS  PubMed  Google Scholar 

Jebbar M, Talibart R, Gloux K, Bernard T, Blanco C (1992) Osmoprotection of Escherichia coli by ectoine: uptake and accumulation characteristics. J Bacteriol 174(15):5027–5035. https://doi.org/10.1128/jb.174.15.5027-5035.1992

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji Y, Li J, Liang Y, Li L, Wang Y, Pi L, Xing P, Nomura CT, Chen S, Zhu C, Wang Q (2024) Engineering the Tat-secretion pathway of Bacillus licheniformis for the secretion of cytoplasmic enzyme arginase. Appl Microbiol Biotechnol 108(1):89. https://doi.org/10.1007/s00253-023-12917-2

Article  CAS  PubMed  Google Scholar 

Kadam P, Barvkar VT, Darshetkar AM, Zinjarde S (2024) The tropical marine actinomycete Nocardiopsis dassonvillei NCIM 5124 as novel source of ectoine: genomic and transcriptomic insights. Gene 930:148860. https://doi.org/10.1016/j.gene.2024.148860

Article  CAS  PubMed  Google Scholar 

Lee WH, Kim JW, Park EH, Han NS, Kim MD, Seo JH (2013) Effects of NADH kinase on NADPH-dependent biotransformation processes in Escherichia coli. Appl Microbiol Biotechnol 97(4):1561–1569. https://doi.org/10.1007/s00253-012-4431-3

Article  CAS  PubMed  Google Scholar 

Liu Z, Yu W, Nomura CT, Li J, Chen S, Yang Y, Wang Q (2018) Increased flux through the TCA cycle enhances bacitracin production by Bacillus licheniformis DW2. Appl Microbiol Biotechnol 102(16):6935–6946. https://doi.org/10.1007/s00253-018-9133-z

Article  CAS  PubMed  Google Scholar 

Liu B, Sun X, Liu Y, Yang M, Wang L, Li Y, Wang J (2022a) Increased NADPH supply enhances glycolysis metabolic flux and L-methionine production in Corynebacterium glutamicum. Foods 11(7). https://doi.org/10.3390/foods11071031

Liu M, Wang C, Ren X, Gao S, Yu S, Zhou J (2022b) Remodelling metabolism for high-level resveratrol production in Yarrowia Lipolytica. Bioresour Technol 365:128178. https://doi.org/10.1016/j.biortech.2022.128178

Article  CAS  PubMed  Google Scholar 

Ma H, Zhao Y, Huang W, Zhang L, Chen GQ (2020) Rational flux-tuning of Halomonas bluephagenesis for co-production of bioplastic PHB and ectoine. Nat Commun 11(1). https://doi.org/10.1038/s41467-020-17223-3

Ma Z, Chang R, Zhu L, Zhu D, Deng Y, Guo X, Cheng Z, Chen X (2024) Metabolic Engineering of Corynebacterium glutamicum for highly efficient production of Ectoine. ACS Synth Biol 13(7):2081–2090. https://doi.org/10.1021/acssynbio.4c00019

Article  CAS  PubMed  Google Scholar 

MacMillan SV, Alexander DA, Culham DE, Kunte HJ, Marshall EV, Rochon D, Wood JM (1999) The ion coupling and organic substrate specificities of osmoregulatory transporter ProP in Escherichia coli. Biochim Biophys Acta 1420(1–2):30–44. https://doi.org/10.1016/s0005-2736(99)00085-1

Article  CAS  PubMed  Google Scholar 

Ning Y, Wu X, Zhang C, Xu Q, Chen N, Xie X (2016) Pathway construction and metabolic engineering for fermentative production of ectoine in Escherichia coli. Metab Eng 36:10–18. https://doi.org/10.1016/j.ymben.2016.02.013

Article  CAS  PubMed  Google Scholar 

Pérez-García F, Ziert C, Risse JM, Wendisch VF (2017) Improved fermentative production of the compatible solute ectoine by Corynebacterium glutamicum from glucose and alternative carbon sources. J Biotechnol 258:59. https://doi.org/10.1016/j.jbiotec.2017.04.039

Article  CAS  PubMed  Google Scholar 

Rao Y, Cai D, Wang H, Xu Y, Xiong S, Gao L, Xiong M, Wang Z, Chen S, Ma X (2020) Construction and application of a dual promoter system for efficient protein production and metabolic pathway enhancement in Bacillus licheniformis. J Biotechnol 312:1–10. https://doi.org/10.1016/j.jbiotec.2020.02.015

Article  CAS  PubMed  Google Scholar 

Rao Y, Li P, Xie X, Li J, Liao Y, Ma X, Cai D, Chen S (2021) Construction and characterization of a gradient strength promoter Library for Fine-tuned gene expression in Bacillus licheniformis. ACS Synth Biol 10(9):2331–2339. https://doi.org/10.1021/acssynbio.1c00242

Article  CAS  PubMed  Google Scholar 

Rao Y, Wang J, Yang X, Xie X, Zhan Y, Ma X, Cai D, Chen S (2023) A novel toolbox for precise regulation of gene expression and metabolic engineering in Bacillus licheniformis. Metab Eng 78:159–170. https://doi.org/10.1016/j.ymben.2023.06.004

Article  CAS  PubMed  Google Scholar 

Schrumpf B, Eggeling L, Sahm H (1992) Isolation and prominent characteristics of an L-lysine hyperproducing strain of Corynebacterium glutamicum. Appl Microbiol Biotechnol 37(5):566–571. https://doi.org/10.1007/BF00240726

Article  CAS  Google Scholar 

Shi J, Zhan Y, Zhou M, He M, Wang Q, Li X, Wen Z, Chen S (2019) High-level production of short branched-chain fatty acids from waste materials by genetically modified Bacillus licheniformis. Bioresour Technol 271:325–331. https://doi.org/10.1016/j.biortech.2018.08.134

Article  CAS  PubMed