Abstract Background: Edentulism in a major global burden that contributes to disability and impairment. Globally, edentulous patients frequently receive removable complete dentures (RCDs) and though crucial, effective adaptation is still difficult. RCD remains a preferred treatment modality for edentulous patients worldwide. The frequency of full edentulism varies both within and between countries.  In Uganda, 1.8% of people aged 20 years and above are edentulous. Despite advances in dental technology and material science, the successful adaptation of RCDs remains a challenge for both patients and dental professionals. Our present study aimed to explore the post-insertion challenges patients presented to dental practitioners during their rehabilitation with removable complete dentures in Makerere University Dental Hospital. Methods: This was a qualitative study using a phenomenological technique and purposive sampling to select 25 participants. After obtaining institutional review board approval and written informed consent, semi-structured in-depth and key informant interviews of dental practitioners were conducted and the data were analyzed thematically. Results: It was revealed that patients with RCDs commonly reported substantial post-insertion challenges like pain and discomfort, drooling, difficulty speaking, eating, oral hygiene and salivating. Patients' confidence and self-esteem were severely influenced by their displeasure with the way their dentures looked. Furthermore, patients frequently had denture instability. In addition, patients received helpful post-insertion advice that emphasized the significance of oral health education and support from dental practitioners. This advice included instructions on denture cleaning, maintenance, and adaption. Conclusion: The present study identified several post-insertion challenges faced by patients after receiving RCDs. It is important to provide integrated support for patients and practitioners to enhance effective RCD therapy.

The authors declare that there is no conflict of interests.

The author(s) received no specific funding for this work.

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

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The study protocol was approved by Makerere University School of Health Sciences Research Ethics Committee (Reference Number: MAKSHSREC-2023-486) and Uganda National Council for Science and Technology (Reference Number: HS3092ES). The administration of the Makerere University Dental Hospital granted permission to conduct the study.

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