Typical biosensing platforms are built on the "lock-and-key" approach, providing high specificity and sensitivity for monitoring environment and food safety, but unable to detect multiple analytes simultaneously. Owing to pattern identification methods, biosensor arrays can distinguish faint fluctuations caused by multi-analytes with similar features in complex systems. As a simple and efficient detection tool, optical biosensor arrays play a vital role in on-site and visible environmental and food safety monitoring. To expand their practical use, enzyme-like nanomaterial (nanozyme)-based biosensor arrays have been designed and employed in optical biosensing platforms due to their exposed active sites and tunable catalytic capabilities. To establish an optical biosensor array, multiple biosensing elements that can specifically interact with analytes to produce distinct "fingerprint" signals are essential, enabling discrimination of different targets via pattern identification. This review provides a comprehensive overview of nanozyme-based optical biosensor arrays for environmental and food safety monitoring. It covers the selective routes of nanozyme-based colorimetric and fluorescent biosensor arrays, compares the response detection platforms based on nanozyme systems, and focuses on the utilization of nanozyme-based optical biosensor arrays for environmental and food hazard monitoring. By evaluating current trends and summarizing the prospects and challenges, this review offers valuable guidance for the rational design of unique nanozyme-based optical biosensor arrays.

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