Hirasawa R, Chiba H, Kaneda M, et al. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 2008;22:1607–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ménézo Y, Lichtblau I. Elder K New insights into human pre-implantation metabolism in vivo and in vitro. J Assist Reprod Genet. 2013;30:293–303.

Article  PubMed  PubMed Central  Google Scholar 

Hoffman M. Hypothesis: hyperhomocysteinhemia is an indicator of oxidant stress. Med Hypotheses. 2011;77:1088–93.

Article  CAS  PubMed  Google Scholar 

Yi P, Melnyk S, Pogribna M, et al. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem. 2000;275(38):29318–23.

Article  CAS  PubMed  Google Scholar 

James SJ, Melnyk S, Pogribna M, et al. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr. 2002;132(Suppl. 8):S2361–6.

Article  Google Scholar 

Zhang T, Huang D, Hou J, et al. High concentration homocysteine inhibits mitochondrial respiration function and production of reactive oxygen species in neuron cells. J Stroke Cerebrovasc Dis. 2020;29:105109.

Article  PubMed  Google Scholar 

Kaye AD, Jeha GM, Pham AD, et al. Folic acid supplementation in patients with elevated homocysteine levels. Adv Ther. 2020;37:4149–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Menezo Y, Elder K, Clement A. Clement P folic acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and one-carbon cycles. Biomolecules. 2022;12:197.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bailey S, Ayling JE. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci USA. 2009;106:15424–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yverneau M, Leroux S, Imbard A, et al. Influence of early identification and therapy on long-term outcomes in early-onset MTHFR deficiency. J Inherit Metab Dis. 2022;45:848–61.

Article  CAS  PubMed  Google Scholar 

Škovierová H, Vidomanová E, Mahmood S, et al. The molecular and cellular effect of homocysteine metabolism imbalance on human health. Int J Mol Sci. 2016;17:E1733.

Article  Google Scholar 

Ducker GS, Rabinowitz JD. One-carbon metabolism in health and disease. Cell Metab. 2017;25(1):27–42.

Article  CAS  PubMed  Google Scholar 

Aitken RJ, Flanagan HM, Connaughton H, et al. Involvement of homocysteine, homocysteine thiolactone, and paraoxonase type 1 (PON-1) in the etiology of defective human sperm function. Andrology. 2016;4:345–60.

Article  CAS  PubMed  Google Scholar 

Troesch B, Demmelmair J, Gimpfl M, et al. MEFOLIN Study Group. Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: a randomized-controlled trial. PLoS ONE. 2019;14:0216790.

Article  Google Scholar 

Obeid R, Warnke I, Bendik I, et al. Infants’ folate markers and postnatal growth in the first 4 months of life in relation to breastmilk and maternal plasma folate MEFOLIN Study Group. Nutrients. 2023;15:1495.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prinz-Langenohl R, Brämswig S, et al. [6S]-5-Methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C–>T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009;158:2014–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clement A, Amar E, Clement P, et al. Hyperhomocysteinemia in hypofertile male patients can be alleviated by supplementation with 5MTHF associated with one carbon cycle support. Front Reprod Health. 2023;5:1229997.

Article  PubMed  PubMed Central  Google Scholar 

Kucuk T, Horozal PE, Karakulak A, Timucin E. Dattilo M Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients. J Assist Reprod Genet. 2023;40:1933–41.

Article  PubMed  PubMed Central  Google Scholar 

Golestanfar A, Niasari-Naslaji A, Jafarpour F, et al. Metabolic enhancement of the one carbon metabolism (OCM) in bovine oocytes IVM increases the blastocyst rate: evidences for a OCM checkpoint. Sci Rep. 2022;12:20629.

Article  CAS  PubMed  PubMed Central  Google Scholar 

El Aarabi M, San Gabriel MC, Chan D, et al. High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism. Hum Mol Genet. 2015;24:6301–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Servy EJ, Jacquesson-Fournols L, Cohen M, Menezo YJR.J MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series. J Assist Reprod Genet 2018; 35:1431–1435

Clement A, Alvarez S, Jacquesson-Fournols L, et al. Women are more protected than men against Hhcy (hyperhomocysteinhemia) during their reproductive life: gener-related differences in one-carbon and folates cycles metabolism. Arch Clin Biomed Res. 2023;7:345–52.

Article  Google Scholar 

Ménézo Y, Patrizio P, Alvarez S, et al. MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility. J Assist Reprod Genet. 2021;38:2383–9.

Article  PubMed  PubMed Central  Google Scholar 

Bergwerff CE, Luman M, Blom HJ, Oosterlaan J. Scand Paediatric reference values for total homocysteine, tryptophan, tyrosine and phenylalanine in blood spots. J Clin Lab Invest. 2017;77:410–4.

Article  CAS  Google Scholar 

Guida V, Calzari L, Fadda MT, et al. Genome-wide DNA methylation analysis of a cohort of 41 patients affected by oculo-auriculo-vertebral spectrum (OAVS). Int J Mol Sci. 2021;22:1190.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai C, Fei Y, Li J, Shi Y, Yang X. A novel review of homocysteine and pregnancy complications. Biomed Res Int. 2021;2021(1):6652231.

PubMed  PubMed Central  Google Scholar 

Boxmeer JC, Macklon NS, Lindemans J, et al. IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid. Hum Reprod. 2009;24:1059–66.

Article  CAS  PubMed  Google Scholar 

Menezo Y, Elder K, Clement P, et al. Biochemical hazards during three phases of assisted reproductive technology: repercussions associated with epigenesis and imprinting. Int J Mol Sci. 2022;23:8916.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berker B, Kaya C, Aytac R, Satiroglu H. Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction. Hum Reprod. 2009;24:2293–302.

Article  CAS  PubMed  Google Scholar 

Rubini E, Snoek KM, Schoenmakers S, Willemsen SP, Sinclair KD, et al. First trimester maternal homocysteine and embryonic and fetal growth: the Rotterdam Periconception Cohort. Nutrients. 2022;14:1129.

Article  PubMed  PubMed Central  Google Scholar 

Schenkelaars N, Schoenmakers S, Rousian M, et al. Periconceptional maternal supplement intake and human embryonic growth, development, and birth outcomes: the Rotterdam Periconception Cohort. Hum Reprod. 2024;39:1925–33.

Article  CAS  PubMed  PubMed Central  Google Scholar