The administration of deep brain stimulation (DBS) in patients with Parkinson's disease is commonly carried out with the patient in an awake state with conscious sedation. However, maintaining the airway and preventing desaturation can be challenging during the procedure. High-flow nasal cannula (HFNC) has been deemed to be a safe option for providing respiratory support in such patients, affording multiple benefits. We report the case of a 48-year-old male patient with Parkinson's disease who underwent DBS, during which HFNC was employed for respiratory support. The patient tolerated the HFNC well, and the procedure was conducted without any complications related to respiratory function.