Short-term repeated oral intake of low dose cannabidiol: effects on liver enzyme activity and creatinine concentration during intense exercise

Alpy A, George Y, Troy S, Petrizzo J, Aquino M, Otto R, John W (2023) Topical cannabidiol and the progression rate of delayed onset muscle soreness. Int J Exercise Sci 16(3):1426–1439

Google Scholar 

Brisola-Santos MB, Gallinaro JG, de Mello E, Gil F, Sampaio-Junior B, Marin MCD, Andrade AG et al (2016) Prevalence and correlates of cannabis use among athletes—a systematic review. Am J Addict 25(7):518–528. https://doi.org/10.1111/ajad.12425

Article  PubMed  Google Scholar 

Burr JF, Cheung CP, Kasper AM, Gillham SH, Close GL (2021) Cannabis and Athletic Performance. Sports Med 51(Suppl 1):75–87. https://doi.org/10.1007/s40279-021-01505-x

Article  PubMed  PubMed Central  Google Scholar 

Calles-Escandon J, Cunningham JJ, Snyder P, Jacob R, Huszar G, Loke J, Felig P (1984) Influence of exercise on urea, creatinine, and 3-methylhistidine excretion in normal human subjects. Am J Physiol 246(4 Pt 1):E334-8. https://doi.org/10.1152/ajpendo.1984.246.4.E334

Article  CAS  PubMed  Google Scholar 

Cannaccord Genuity (2019) Estimated annual CBD usage rate in the United States from 2018-2024, 09.09.2019. Online verfügbar unter https.//www.statista.com/statistics/1065834/annual-cbd-usage-rate-us/

Caputi Theodore L (2022) Re: “observed impact of long-term consumption of oral cannabidiol on liver function in healthy adults” and a recent announcement of a new cannabidiol safety study. Cannabis Cannabinoid Res 7(6):896–897. https://doi.org/10.1089/can.2022.0191

Article  PubMed  PubMed Central  Google Scholar 

Chapman CL, Johnson BD, Vargas NT, Hostler D, Parker MD, Schlader ZJ (2020) Both hyperthermia and dehydration during physical work in the heat contribute to the risk of acute kidney injury. J Appl Physiol 128(4):715–728. https://doi.org/10.1152/japplphysiol.00787.2019

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Erlbaum, Hillsdale

Google Scholar 

Crippa JAS, Zuardi AW, Guimarães FS, Campos Alline C, Lima O, Loureiro SR et al (2021) Efficacy and safety of cannabidiol plus standard care vs standard care alone for the treatment of emotional exhaustion and burnout among frontline health care workers during the COVID-19 pandemic: a randomized clinical trial. JAMA Netw Open 4(8):e2120603. https://doi.org/10.1001/jamanetworkopen.2021.20603

Article  PubMed  PubMed Central  Google Scholar 

Dietz T, Gerstenlauer J, Sproll C, Walch SG, Lachenmeier DW (2022) Cannabidiol (CBD) in Lebensmitteln—Beurteilung der Sicherheit: Gesundheitsschädlich bei über 300 mg/Tag. Deutsche Lebensmittel-Rundschau 118(11):446–453. https://doi.org/10.5281/ZENODO.7350327

Article  Google Scholar 

Docter S, Khan M, Gohal C, Ravi B, Bhandari M, Gandhi R, Leroux T (2020) Cannabis use and sport: a systematic review. Sports Health 12(2):189–199. https://doi.org/10.1177/1941738120901670

Article  PubMed  PubMed Central  Google Scholar 

European Drug Report (2023): Cannabis—the current situation in Europe. Online verfügbar unter https://www.euda.europa.eu/publications/european-drug-report/2023/cannabis_en#level-1-section1

Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA et al (2019) Hepatotoxicity of a cannabidiol-rich cannabis extract in the mouse model. Molecules. https://doi.org/10.3390/molecules24091694

Article  PubMed  PubMed Central  Google Scholar 

García-Cardona D, Landázuri P, Sánchez-Muñoz O (2021) Effect of a shock micro-cycle on biochemical markers in university soccer players. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph18073581

Article  PubMed  PubMed Central  Google Scholar 

Gingrich J, Choudhuri S, Cournoyer P, Downey J, Jacobs M (2023) Review of the oral toxicity of cannabidiol (CBD). Food Chem Toxicol 176:113799. https://doi.org/10.1016/j.fct.2023.113799

Article  CAS  PubMed  Google Scholar 

Haynes B, Khan T, Willis R, Alexander-White C, Boobis A (2023) Joint position paper from the Advisory Committee on Novel Foods and Processes (ACNFP) & Committee on Toxicity (COT) on establishing a provisional acceptable daily intake (ADI) for pure form (≥98%) cannabidiol (CBD) in foods, based on new evidence

Isenmann E, Veit S, Starke L, Flenker U, Diel P (2021) Effects of cannabidiol supplementation on skeletal muscle regeneration after intensive resistance training. Nutrients. https://doi.org/10.3390/nu13093028

Article  PubMed  PubMed Central  Google Scholar 

Isenmann E, Veit S, Flenker U, Lesch A, Lachenmeier DW, Diel P (2024) Influence of short-term chronic oral cannabidiol application on muscle recovery and performance after an intensive training protocol—a randomized double-blind crossover study. J Int Soc Sports Nutr 21(1):2337252. https://doi.org/10.1080/15502783.2024.2337252

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaufmann R, Aqua K, Lombardo J, Lee M (2023) Observed impact of long-term consumption of oral cannabidiol on liver function in healthy adults. Cannabis Cannabinoid Res 8(1):148–154. https://doi.org/10.1089/can.2021.0114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaufmann R, Harris Bozer A, Jotte ARK, Aqua K (2023) The effects of long-term self-dosing of cannabidiol on drowsiness, testosterone levels, and liver function. Med Cannabis Cannabinoids 6(1):32–40. https://doi.org/10.1159/000529677

Article  PubMed  PubMed Central  Google Scholar 

Lachenmeier DW, Sproll C, Walch SG (2023) Does cannabidiol (CBD) in food supplements pose a serious health risk? Consequences of the European Food Safety Authority (EFSA) clock stop regarding novel food authorisation. Psychoactives 2(1):66–75. https://doi.org/10.3390/psychoactives2010005

Article  Google Scholar 

Lehmann M, Dickhuth HH, Gendrisch G, Lazar W, Thum M, Kaminski R et al (1991) Training-overtraining. A prospective, experimental study with experienced middle- and long-distance runners. Int J Sports Med 12(5):444–452. https://doi.org/10.1055/s-2007-1024711

Article  CAS  PubMed  Google Scholar 

Poortmans JR (1984) Exercise and renal function. Sports Med 1(2):125–153. https://doi.org/10.2165/00007256-198401020-00003

Article  CAS  PubMed  Google Scholar 

Poortmans JR, Vanderstraeten J (1994) Kidney function during exercise in healthy and diseased humans. An update. Sports medicine 18(6):419–437. https://doi.org/10.2165/00007256-199418060-00006

Article  CAS  PubMed  Google Scholar 

Rojas-Valverde Daniel, Fallas-Campos Andrea (2023) Cannabidiol in sports: insights on how CBD could improve performance and recovery. Front Pharmacol 14:1210202. https://doi.org/10.3389/fphar.2023.1210202

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenthal Robert, Rosnow Ralph L, Chiappetta Maria E (eds) (1991) Essentials of behavioral research. Methods and data analysis, 2nd edn. McGraw-Hill (McGraw-Hill series in psychology), New York

Google Scholar 

Ross B, Trojian T, Cushman DM (2023) Physician perceptions of cannabidiol (CBD) and cannabis in sports medicine and performance. Transla Sports Med 2023:8824466. https://doi.org/10.1155/2023/8824466

Article  Google Scholar 

Rubio-Arias JÁ, Ávila-Gandía V, López-Román FJ, Soto-Méndez F, Alcaraz PE, Ramos-Campo DJ (2019) Muscle damage and inflammation biomarkers after two ultra-endurance mountain races of different distances: 54 km vs 111 km. Physiol Behav 205:51–57. https://doi.org/10.1016/j.physbeh.2018.10.002

Article  CAS  PubMed  Google Scholar 

Santos Junior ERT, Salles BF, Dias I, Ribeiro AS, Simão R, Willardson JM (2021) Classification and determination model of resistance training status. Strength Condition J 43(5):77–86. https://doi.org/10.1519/SSC.0000000000000627

Article  Google Scholar 

Stohs SJ, Ray SD (2020) Is cannabidiol hepatotoxic or hepatoprotective: a review. Toxicol Res Appl 4:239784732092294. https://doi.org/10.1177/2397847320922944

Article  CAS  Google Scholar 

Takahashi A, Sekiya C, Yazaki Y, Ono M, Sato H, Hasebe C et al (1986) Hepatic GOT and GPT activities in patients with various liver diseases–especially alcoholic liver disease. Hokkaido J Med Sci 61(3):431–436

CAS  PubMed  Google Scholar 

Team RC (2014) R: A language and environment for statistical computing. MSOR connections, 1

Veit S, Isenmann E, Diel P (2020) Effect of acute cannabidiol supplementation on recovery after strenuous strength training.

Vilela LR, Gomides LF, David BA, Antunes MM, Diniz AB, Moreira FA, Menezes GB (2015) Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. Mediators Inflamm. https://doi.org/10.1155/2015/523418

Article  PubMed  PubMed Central  Google Scholar 

Ware MA, Jensen D, Barrette A, Vernec A, Derman W (2018) Cannabis and the health and performance of the elite athlete. Clin J Sport Med 28(5):480–484.

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