Rudd KE, Johnson SC, Agesa KM et al (2020) Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet Lond Engl 395:200–211. https://doi.org/10.1016/S0140-6736(19)32989-7
Shankar-Hari M, Phillips GS, Levy ML et al (2016) Developing a new definition and assessing new clinical criteria for septic shock. JAMA 315:775–787. https://doi.org/10.1001/jama.2016.0289
Article CAS PubMed PubMed Central Google Scholar
Vincent J-L, Jones G, David S et al (2019) Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis. Crit Care 23:196. https://doi.org/10.1186/s13054-019-2478-6
Article PubMed PubMed Central Google Scholar
Kwok AJ, Allcock A, Ferreira RC et al (2023) Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis. Nat Immunol 24:767–779. https://doi.org/10.1038/s41590-023-01490-5
Article CAS PubMed Google Scholar
Johnson CL, Soeder Y, Dahlke MH (2017) Concise review: mesenchymal stromal cell-based approaches for the treatment of acute respiratory distress and sepsis syndromes. Stem Cells Transl Med 6:1141–1151. https://doi.org/10.1002/sctm.16-0415
Article PubMed PubMed Central Google Scholar
Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801. https://doi.org/10.1001/jama.2016.0287
Article CAS PubMed PubMed Central Google Scholar
Ghimire S, Ravi S, Budhathoki R et al (2021) Current understanding and future implications of sepsis-induced thrombocytopenia. Eur J Haematol 106:301–305. https://doi.org/10.1111/ejh.13549
Loftus TJ, Mohr AM, Moldawer LL (2018) Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult. Curr Opin Hematol 25:37–43. https://doi.org/10.1097/MOH.0000000000000395
Article CAS PubMed PubMed Central Google Scholar
Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 13:862–874. https://doi.org/10.1038/nri3552
Article CAS PubMed PubMed Central Google Scholar
Liu VX, Fielding-Singh V, Greene JD et al (2017) The timing of early antibiotics and hospital mortality in sepsis. Am J Respir Crit Care Med 196:856–863. https://doi.org/10.1164/rccm.201609-1848OC
Article PubMed PubMed Central Google Scholar
Rhodes A, Evans LE, Alhazzani W et al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Crit Care Med 45:486–552. https://doi.org/10.1097/CCM.0000000000002255
Seymour CW, Gesten F, Prescott HC et al (2017) Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med 376:2235–2244. https://doi.org/10.1056/NEJMoa1703058
Article PubMed PubMed Central Google Scholar
Laroye C, Gibot S, Huselstein C, Bensoussan D (2020) Mesenchymal stromal cells for sepsis and septic shock: lessons for treatment of COVID-19. Stem Cells Transl Med 9:1488–1494. https://doi.org/10.1002/sctm.20-0239
Article CAS PubMed PubMed Central Google Scholar
Lalu MM, Sullivan KJ, Mei SH et al (2016) Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial. Elife. https://doi.org/10.7554/eLife.17850
Article PubMed PubMed Central Google Scholar
Mei SHJ, Haitsma JJ, Dos Santos CC et al (2010) Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med 182:1047–1057. https://doi.org/10.1164/rccm.201001-0010OC
Article CAS PubMed Google Scholar
Németh K, Leelahavanichkul A, Yuen PST et al (2009) Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15:42–49. https://doi.org/10.1038/nm.1905
Article CAS PubMed Google Scholar
McIntyre LA, Stewart DJ, Mei SHJ et al (2018) Cellular immunotherapy for septic shock. A Phase I clinical trial. Am J Respir Crit Care Med 197:337–347. https://doi.org/10.1164/rccm.201705-1006OC
Article CAS PubMed Google Scholar
Schlosser K, Wang J-P, Dos Santos C et al (2019) Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients. Crit Care Med 47:918–925. https://doi.org/10.1097/CCM.0000000000003657
Article CAS PubMed PubMed Central Google Scholar
Le Blanc K, Davies LC (2015) Mesenchymal stromal cells and the innate immune response. Immunol Lett 168:140–146. https://doi.org/10.1016/j.imlet.2015.05.004
Article CAS PubMed Google Scholar
Abbasi B, Shamsasenjan K, Ahmadi M et al (2022) Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications. Stem Cell Res Ther 13:97. https://doi.org/10.1186/s13287-022-02777-4
Article CAS PubMed PubMed Central Google Scholar
Quaglia M, Fanelli V, Merlotti G et al (2022) Dual role of extracellular vesicles in sepsis-associated kidney and lung injury. Biomedicines 10:2448. https://doi.org/10.3390/biomedicines10102448
Article CAS PubMed PubMed Central Google Scholar
Cheng Y, Cao X, Qin L (2020) Mesenchymal stem cell-derived extracellular vesicles: a novel cell-free therapy for sepsis. Front Immunol 11:647. https://doi.org/10.3389/fimmu.2020.00647
Article CAS PubMed PubMed Central Google Scholar
Herrera MB, Bruno S, Buttiglieri S et al (2006) Isolation and Characterization of a Stem Cell Population from Adult Human Liver. Stem Cells 24:2840–2850. https://doi.org/10.1634/stemcells.2006-0114
Article CAS PubMed Google Scholar
Bruno S, Herrera Sanchez MB, Chiabotto G et al (2021) Human liver stem cells: a liver-derived mesenchymal stromal cell-like population with pro-regenerative properties. Front Cell Dev Biol 9:644088. https://doi.org/10.3389/fcell.2021.644088
Article PubMed PubMed Central Google Scholar
Bruno S, Herrera Sanchez MB, Pasquino C et al (2019) Human liver-derived stem cells improve fibrosis and inflammation associated with nonalcoholic steatohepatitis. Stem Cells Int 2019:6351091. https://doi.org/10.1155/2019/6351091
Article CAS PubMed PubMed Central Google Scholar
Herrera MB, Fonsato V, Bruno S et al (2013) Human liver stem cells improve liver injury in a model of fulminant liver failure. Hepatology 57:311–319. https://doi.org/10.1002/hep.25986
Article CAS PubMed Google Scholar
Fonsato V, Lena MD, Tritta S, et al (2018) Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation. Oncotarget 9:36151. https://doi.org/10.18632/oncotarget.26319
Fanelli V, Puntorieri V, Assenzio B et al (2010) Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema. Intensive Care Med 36:1935–1945. https://doi.org/10.1007/s00134-010-2018-y
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