A recent accreditation requirement for medical education calls for innovative approaches to creating a health promotion curriculum (HPC) and interprofessional education. We developed an interprofessional HPC focused on 10 evidence-based interventions (acceptance and commitment, active rest, emotional freedom, emotional intelligence, mindfulness, nutrition, physical activity, psychological detachment, sleep, yoga) that promote peer learning and skill enhancement with active, self-directed learning, practice activities, group interaction, and reflections for medical, nursing, physical therapy, social work, and counseling students. Quality improvement was performed using feedback from students and faculty. HPC was piloted with 552 learners, optimized, and redeployed with 132 learners. This approach and curriculum can be adopted by other institutions.