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Topic: Cancer biology
Category: Review
Glioblastoma is recognized as the most aggressive tumor of the central nervous system, accounting for the majority of gliomas (57.3%) and approximately 15% of all brain tumors. Additionally, it represents 48.3% of primary malignant intracranial tumors. Overall survival extension among patients with glioblastoma remains challenging despite improvements in post-surgical treatments, including chemotherapy and radiotherapy. Consequently, the development of novel therapeutic approaches specifically targeting glioma is of critical clinical relevance. Long non-coding RNAs, a class of non-coding RNAs longer than 200 nucleotides (nt), once considered as “noise” of transcription, are now acknowledged to play a critical role in a variety of molecular processes at the transcriptional, post-transcriptional, and epigenetic levels, as well as in numerous physiological and pathological processes. A dysregulation of lncRNAs in glioma affects and alters many signaling pathways. A significant number of these lncRNAs have been discovered due to advances in high-throughput sequencing technology, which has also revealed their strong correlation with tumor development and progression, as well as their interaction with microRNAs. Nowadays, lncRNAs are thought to be promising targets for diagnostic, prognostic, and therapeutic purposes. In this review, we will describe some lncRNAs and detail their classification and cellular localization, as well as their mechanisms of action and how they affect and alter many signaling pathways in glioblastoma. We will also discuss several research strategies for identifying and characterizing lncRNAs in tumors.
To cite this article Bouchra O. Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco WCRJ 2024;
11
: e2845
DOI: 10.32113/wcrj_202411_2845
Submission date: 30 Apr 2024
Revised on: 17 Jun 2024
Accepted on: 27 Sep 2024
Published online: 25 Nov 2024
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