Objective Depression is a chronic condition that affects millions of people and requires effective interventions. Studies suggest that aerobic exercise can improve mental health and reduce depression symptoms, despite variations in exercise type and intensity. The aim of this study will be to analyze the effect of aerobic exercise on reducing depression in adults.

Methods This is a systematic review protocol, which will follow the PRISMA-P 2020 guidelines and has been registered in PROSPERO (no. CRD42024592700). The study search will be conducted in five databases: PubMed, Embase, Cochrane, BVS, and SPORTDiscus, using MeSH-based descriptors. Studies will be selected independently by two researchers using the Rayyan ‘QCRI’ software. Data extraction will be conducted with specific forms, and the methodological quality of the studies will be assessed using the Cochrane RoB 2.0 method. The certainty of evidence will be evaluated through the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).

Conclusions The systematic review is expected to identify the effective dose-response for reducing depression levels and provide understanding of the mechanisms through which aerobic exercise influences depression.

The authors have declared no competing interest.

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