Mellouki A, Bentellis I, Morrone A, Doumerc N, Beauval J-B, Roupret M. et al. Evaluation of oncological outcomes of robotic partial nephrectomy according to the type of hilar control approach (On-clamp vs Off-clamp), a multicentric study of the French network of research on kidney cancer—UROCCR 58-NCT03293563. World J Urol. 2021;41:287–94.https://doi.org/10.1007/s00345-020-03558-5.

Article  PubMed  Google Scholar 

Kim SR, Kim K, Lee SA, Kwon SO, Lee JK, Keum N, et al. Effect of red, processed, and white meat consumption on the risk of gastric cancer: An overall and dose-response meta-analysis. Nutrients. 2019;11:826

Article  PubMed  PubMed Central  Google Scholar 

Kuntz S, Krieghoff-Henning E, Kather JN, Jutzi T, Höhn J, Kiehl L, et al. Gastrointestinal cancer classification and prognostication from histology using deep learning: Systematic review. Eur J Cancer. 2021;155:200–15.

Article  PubMed  Google Scholar 

Guan W-L, He Y, Xu R-H. Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol. 2023;16. https://doi.org/10.1186/s13045-023-01451-3.

Xingming D, Zhuofei L, Guan L, Bei L, Xinhan J, Guoqing L. Comparison of microbiota in patients treated by surgery or chemotherapy by 16S rRNA sequencing reveals potential biomarkers for colorectal cancer therapy. Front Microbiol. 2018;9:1607.

Article  Google Scholar 

Zhang S, Yang Y, Weng W, Guo B, Cai G, Ma Y, et al. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. J Exp Clin Cancer Res. 2019; 38.

Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015;350:1084–9.

Article  PubMed  PubMed Central  Google Scholar 

Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015;350:1079–84.

Article  PubMed  PubMed Central  Google Scholar 

Zheng C, Chen T, Wang Y, Gao Y, Kong Y, Liu Z, et al. A randomised trial of probiotics to reduce severity of physiological and microbial disorders induced by partial gastrectomy for patients with gastric cancer. J Cancer. 2019;10:568–76.

Article  PubMed  PubMed Central  Google Scholar 

Qian J-P, Jiang B, Lei X-D, Tian L-L, Zhou Y, Teng J-Q, et al. Influence of gut microecology in the development of malignant tumors and its potential therapeutic application: a review. Medicine. 2023;102:e34274.

Article  PubMed  PubMed Central  Google Scholar 

Xia C, Jiang C, Li W, Wei J, Hong H, Li J, et al. A phase II randomized clinical trial and mechanistic studies using improved probiotics to prevent oral mucositis induced by concurrent radiotherapy and chemotherapy in nasopharyngeal carcinoma. Front Immunol. 2021;12:618150.

Article  PubMed  PubMed Central  Google Scholar 

Huang F, Li S, Chen W, Han Y, Yao Y, Yang L, et al. Postoperative probiotics administration attenuates gastrointestinal complications and gut microbiota dysbiosis caused by chemotherapy in colorectal cancer patients. Nutrients. 2023;15:356.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Chen S, Lin H, Luo B, Qiu J. To investigate the effect of perioperative probiotic therapy on patients undergoing neoadjuvant chemotherapy combined with radical gastrectomy. Chin foreign Med Res. 2023;21:60–6.

Google Scholar 

Chen J. Effects of probiotics on intestinal flora and chemotherapy-related complications in patients with gastric cancer undergoing chemotherapy. Diet Health Care. 2019;6:62.

Google Scholar 

Chen Q, Zhu J, Xu Y. To investigate the effects of probiotics on nutritional status, inflammatory response and chemotherapy-related complications in patients with colorectal cancer undergoing chemotherapy. Health Res. 2020;40:4.

Google Scholar 

Chen W. Effect of probiotics combined with enteral nutrition preparation on patients with colorectal cancer undergoing postoperative chemotherapy. Hubei University of Medicine.

Dong J, Cheng X, Yang Z, LI M, Yu K. To observe the effect of Bifidobacterium triple viable capsule combined with oxaliplatin on intestinal flora and immune function after colorectal cancer surgery. West Med. 2019;31:5.

Google Scholar 

Lu H. Effects of synbiotics on postoperative chemotherapy side effects and intestinal flora in patients with colorectal cancer: a randomized controlled clinical trial. Tongji University.

Xu C, Han M, Xu F, Wang S. Clinical study on the effect of chemotherapy drugs on intestinal flora in patients with gastric cancer and the intervention effect of probiotics. Chin J Digest Dis Imaging (Electr Edition). 2016;6:154–9.

Google Scholar 

Yang Y, Zhao Y. To investigate the effect of alanyl-glutamine and Bifidobacterium triple viable capsule on intestinal barrier function in postoperative adjuvant chemotherapy for colorectal cancer. Chin J Mod Med. 2020 30, 15, 79-84.

Zhang Y To investigate the effect of probiotics combined with enteral nutrition on myelosuppression after chemotherapy in patients with gastric cancer. Chengde Medical College.

Zhuang Z, Yu J, Luo T. Effects of probiotics on the microecology of intestinal flora in patients with gastric cancer. Contemp Med. 2022;017:028.

Google Scholar 

Mego M, Chovanec J, Vochyanova-Andrezalova I, Konkolovsky P, Mikulova M, Reckova M, et al. Prevention of irinotecan induced diarrhea by probiotics: a randomized double blind, placebo controlled pilot study. Complement Ther Med. 2015;23:356–62.

Article  PubMed  Google Scholar 

Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, Porsok S, et al. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12®Lactobacillus rhamnosus LGG® in colorectal cancer patients. Front Oncol. 2023;13. https://doi.org/10.3389/fonc.2023.1168654.

Österlund P, Ruotsalainen T, Korpela R, Saxelin M, Ollus A, Valta P, et al. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. Br J cancer. 2007;97:1028–34.

Article  PubMed  PubMed Central  Google Scholar 

Zaharuddin L, Mokhtar NM, Muhammad Nawawi KN, Raja Ali RA. A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer. BMC Gastroenterol. 2019;19:131.

Article  PubMed  PubMed Central  Google Scholar 

Shadnoush M, Hosseini RS, Mehrabi Y, Delpisheh A, Alipoor E, Faghfoori Z, et al. Probiotic yogurt affects pro- and anti-inflammatory factors in patients with inflammatory bowel disease. Iran J Pharmaceut Res. 2013;12:929–36.

Google Scholar 

Liang S, Xu L, Zhang D, Wu Z. Effect of probiotics on small intestinal bacterial overgrowth in patients with gastric and colorectal cancer. Turkish J Gastroenterol. 2016;27:227–32.

Article  Google Scholar 

Wang S, Wang J, Chen C. Research progress on the mechanism and prevention of chemotherapy-induced intestinal barrier dysfunction. Shandong Med. 2021;61:88–91.

Google Scholar 

Qian X, Zha J, Xu W. To investigate the effect of probiotics assisted conventional therapy on postoperative serum laboratory indexes and safety in patients with early gastric cancer. Med Innov China. 2022;19:4.

Google Scholar 

Huang J, Lucero-Prisno DE, 3rd, Zhang L, Xu W, Wong SH, et al. Updated epidemiology of gastrointestinal cancers in East Asia. Nat Rev Gastroenterol Hepatol. 2023; 20: 271-87. e-pub ahead of print 20230111; https://doi.org/10.1038/s41575-022-00726-3

Tan D, Yao H. Application of Livzon Enterle in chemotherapy of malignant tumors of digestive tract. Contemp Med. 2001;7:3.

Google Scholar 

Ciorba MA, Hallemeier CL, Stenson WF, Parikh PJ. Probiotics to prevent gastrointestinal toxicity from cancer therapy: an interpretive review and call to action. Curr Opin Support Palliat Care. 2015;9:157.

Article  PubMed  PubMed Central  Google Scholar 

Lu D, Yan J, Liu F, Ding P, Sun Z. Probiotics in preventing and treating chemotherapy-induced diarrhea: a meta-analysis. Asia Pac J Clin Nutr. 2019;28:701–10.

PubMed  Google Scholar 

SL A, YS B. The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer: A systematic review and meta-analysis based on 23 randomized studies. Int J Surg. 2020;84:69–77.

Article  Google Scholar 

Dasari S, Kathera C, Janardhan A, Kumar AP, Viswanath B. Surfacing role of probiotics in cancer prophylaxis and therapy: a systematic review. Clin Nutr. 2017;36:1465–72.

Article  PubMed  Google Scholar 

Bowen JM, Stringer AM, Gibson RJ, Yeoh AS, Hannam S, Keefe DM. VSL#3 probiotic treatment reduces chemotherapy-induced diarrhoea and weight loss. Cancer Biol Ther. 2007;9:1449–54.

Google Scholar 

Yeung CY, Chan WT, Jiang CB, Cheng ML, Liu CY, Chang SW, et al. Amelioration of chemotherapy-induced intestinal mucositis by orally administered probiotics in a mouse model. Plos One. 2015;10:e0138746.

Article  PubMed  PubMed Central  Google Scholar 

Liang Q, Zhang L, Duan S, Wang P, Zhang Y, Luo J, et al. Effects of intestinal flora imbalance on immune and hematopoietic function in mice. Chin J Pediatrics. 2004;42:4.

Google Scholar 

Liang Z, Ga W, LI P, Dong Z, Du M, Wang J. Effect of oral probiotics on intestinal flora in patients with colorectal cancer undergoing chemotherapy: a Meta-analysis. J Baotou Med Coll. 2023;39:32–6.

Google Scholar 

Liu Y, Zhang L, Yuan Q, Xu Y, Hu Y, Jin Q, et al. Efficacy of probiotics combined with enteral nutrition versus enteral nutrition alone in improving the prognosis of patients with gastric cancer surgery: a Meta-analysis. Chin J Microecol. 2021;33:7.

Google Scholar