This review article comprehensively examines the synthesis, application, and future of carbon-phosphorus (C-P) bond chemistry. It begins by highlighting the essential role of C-P bonds in biological and industrial contexts and traces the historical progression of C-P bond research. The article critically analyzes current methodologies, emphasizing the transition from traditional to modern synthetic methods, and assesses their efficiency, scalability, and environmental impact. It contrasts biotechnological and chemical synthesis, underlining the importance of precision and innovation in developing novel C-P structures. The review addresses the integration of green chemistry principles in C-P compound synthesis and outlines strategies to overcome scalability and compound stability challenges. A forward-looking perspective is presented on the role of computational tools and machine learning in optimizing C-P synthesis and discovering new compounds. The article concludes by exploring the transformative potential of C-P compounds in healthcare and agriculture and calls for increased collaboration across disciplines to drive scientific and technological advancements.

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