Richards GM, Tomé WA, Robins HI, Stewart JA, Welsh JS, Mahler PA, et al. Pulsed reduced dose-rate radiotherapy: a novel locoregional retreatment strategy for breast cancer recurrence in the previously irradiated chest wall, axilla, or supraclavicular region. Breast Cancer Res Treat. 2009;114(2):307–13.

Article  PubMed  Google Scholar 

Adkison JB, Tomé W, Seo S, Richards GM, Robins HI, Rassmussen K, et al. Reirradiation of large-volume recurrent glioma with pulsed reduced-dose-rate radiotherapy. Int J Radiat Oncol Biol Phys. 2011;79(3):835–41.

Article  PubMed  Google Scholar 

Ma CM, Lin MH, Dai XF, Koren S, Klayton T, Wang L, et al. Investigation of pulsed low dose rate radiotherapy using dynamic arc delivery techniques. Phys Med Biol. 2012;57(14):4613–26.

Article  PubMed  Google Scholar 

Lin MH, Price RA, Li J, Kang S, Li J, Ma CM. Investigation of pulsed IMRT and VMAT for re-irradiation treatments: dosimetric and delivery feasibilities. Phys Med Biol. 2013;58(22):8179–96.

Article  PubMed  Google Scholar 

Wang B, Ren J, Zhang P, Cvetkovic D, Chen X, Chen L, et al. An in-vivo study on pulsed low-dose-rate radiotherapy for prostate cancer. Mathews J Cancer Sci. 2019;4(2):1–7.

Article  Google Scholar 

Hall EJ, Giaccia AJ. Radiobiology for the Radiologist. Lippincott Williams & Wilkins; 2006. 572 p.

Tomé WA, Howard SP. On the possible increase in local tumour control probability for gliomas exhibiting low dose hyper-radiosensitivity using a pulsed schedule. Br J Radiol. 2007;80(949):32–7.

Article  PubMed  Google Scholar 

Ma CMC, Luxton G, Orton CG. Point/counterpoint: pulsed reduced dose rate radiation therapy is likely to become the treatment modality of choice for recurrent cancers. Med Phys. 2011;38(9):4909–11.

Article  PubMed  Google Scholar 

Ma CMC. Pulsed low dose-rate radiotherapy: radiobiology and dosimetry. Phys Med Biol. 2022;67(3):0301.

Article  Google Scholar 

Joiner MC, Marples B, Lambin P, Short SC, Turesson I. Low-dose hypersensitivity: current status and possible mechanisms. Int J Radiat Oncol Biol Phys. 2001;49(2):379–89.

Article  CAS  PubMed  Google Scholar 

Marples B, Collis SJ. Low-dose hyper-radiosensitivity: past, present, and future. Int J Radiat Oncol Biol Phys. 2008;70(5):1310–8.

Article  PubMed  Google Scholar 

Wykes SM, Piasentin E, Joiner MC, Wilson GD, Marples B. Low-dose hyper-radiosensitivity is not caused by a failure to recognize DNA double-strand breaks. Radiat Res. 2006;165(5):516–24.

Article  CAS  PubMed  Google Scholar 

Hall EJ, Brenner DJ. The dose-rate effect revisited: radiobiological considerations of importance in radiotherapy. Int J Radiat Oncol Biol Phys. 1991;21(6):1403–14.

Article  CAS  PubMed  Google Scholar 

Dai X, Tao D, Wu H, Cheng J. Low dose hyper-radiosensitivity in human lung cancer cell line A549 and its possible mechanisms. J Huazhong Univ Sci Technol Med Sci Hua Zhong Ke Ji Xue Xue Bao Yi Xue Ying Wen Ban Huazhong Keji Daxue Xuebao Yixue Yingdewen Ban. 2009;29(1):101–6.

Article  CAS  Google Scholar 

Singh B, Arrand JE, Joiner MC. Hypersensitive response of normal human lung epithelial cells at low radiation doses. Int J Radiat Biol. 1994;65(4):457–64.

Article  CAS  PubMed  Google Scholar 

Short SC, Kelly J, Mayes CR, Woodcock M, Joiner MC. Low-dose hypersensitivity after fractionated low-dose irradiation in vitro. Int J Radiat Biol. 2001;77(6):655–64.

Article  CAS  PubMed  Google Scholar 

Harney J, Short SC, Shah N, Joiner M, Saunders MI. Low dose hyper-radiosensitivity in metastatic tumors. Int J Radiat Oncol Biol Phys. 2004;59(4):1190–5.

Article  PubMed  Google Scholar 

Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, et al. Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-κB activity. Int J Radiat Oncol Biol Phys. 2009;75(2):534–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin LM, Marples B, Lynch TH, Hollywood D, Marignol L. Exposure to low dose ionising radiation: molecular and clinical consequences. Cancer Lett. 2014;349(1):98–106.

Article  CAS  PubMed  Google Scholar 

Joiner MC, Lambin P, Malaise EP, Robson T, Arrand JE, Skov KA, et al. Hypersensitivity to very-low single radiation doses: its relationship to the adaptive response and induced radioresistance. Mutat Res. 1996;358(2):171–83.

Article  PubMed  Google Scholar 

Marples B, Joiner MC, Skov KA. The effect of oxygen on low-dose hypersensitivity and increased radioresistance in Chinese hamster V79–379A cells. Radiat Res. 1994;138(1 Suppl):S17-20.

Article  CAS  PubMed  Google Scholar 

Xu B, Kim ST, Lim DS, Kastan MB. Two molecularly distinct G2/M checkpoints are induced by ionizing irradiation. Mol Cell Biol. 2002;22(4):1049–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Short SC, Woodcock M, Marples B, Joiner MC. Effects of cell cycle phase on low-dose hyper-radiosensitivity. Int J Radiat Biol. 2003;79(2):99–105.

Article  CAS  PubMed  Google Scholar 

Krempler A, Deckbar D, Jeggo PA, Löbrich M. An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle Georget Tex. 2007;6(14):1682–6.

Article  CAS  Google Scholar 

Leonard BE. Thresholds and transitions for activation of cellular radioprotective mechanisms - correlations between HRS/IRR and the “inverse” dose-rate effect. Int J Radiat Biol. 2007;83(7):479–89.

Article  CAS  PubMed  Google Scholar 

Mitchell CR, Folkard M, Joiner MC. Effects of exposure to low-dose-rate (60)co gamma rays on human tumor cells in vitro. Radiat Res. 2002;158(3):311–8.

Article  CAS  PubMed  Google Scholar 

Matsuya Y, McMahon SJ, Tsutsumi K, Sasaki K, Okuyama G, Yoshii Y, et al. Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates. Sci Rep. 2018;8(1):8287.

Article  PubMed  PubMed Central  Google Scholar 

Todorovic V, Prevc A, Zakelj MN, Savarin M, Bucek S, Groselj B, et al. Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity. Radiol Oncol. 2020;54(2):168–79.

Article  PubMed  PubMed Central  Google Scholar 

Liu H, Shen C, Klages P, Albuquerque K, Ma CM, Jia X. Investigation of dose-rate effects in pulsed low dose rate radiotherapy. Mathews J Cancer Sci. 2022;7(2):1–6.

Article  Google Scholar 

Ma C, Mu Z, Tafo AG, Chen L. Variation of cytotoxic effect with pulsed dose sequence and low dose rate radiation. Int J Radiat Oncol. 2010;78(3):S629.

Article  Google Scholar 

Zhang P, Wang B, Chen X, Cvetkovic D, Chen L, Lang J, et al. Local tumor control and normal tissue toxicity of pulsed low-dose rate radiotherapy for recurrent lung cancer. Dose-Response. 2015;13(2):1559325815588507.

Article  PubMed  PubMed Central  Google Scholar 

Dilworth JT, Krueger SA, Dabjan M, Grills IS, Torma J, Wilson GD, et al. Pulsed low-dose irradiation of orthotopic glioblastoma multiforme (GBM) in a pre-clinical model: effects on vascularization and tumor control. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2013;108(1):149–54.

Article  Google Scholar 

Park SS, Chunta JL, Robertson JM, Martinez AA, Oliver Wong CY, Amin M, et al. MicroPET/CT imaging of an orthotopic model of human glioblastoma multiforme and evaluation of pulsed low-dose irradiation. Int J Radiat Oncol. 2011;80(3):885–92.

Article  Google Scholar 

Meyer K, Krueger SA, Kane JL, Wilson TG, Hanna A, Dabjan M, et al. Pulsed radiation therapy with concurrent cisplatin results in superior tumor growth delay in a head and neck squamous cell carcinoma murine model. Int J Radiat Oncol Biol Phys. 2016;96(1):161–9.

Article  CAS  PubMed