Faul M, Coronado V (2015) Epidemiology of traumatic brain injury. Handb Clin Neurol 127:3–13

Article  PubMed  Google Scholar 

Williamson C, Rajajee V (2023) Traumatic brain injury: epidemiology, classification, and pathophysiology. In: Post TW (ed) UpToDate. UpToDate, Waltham

Capizzi A, Woo J, Verduzco-Gutierrez M (2020) Traumatic brain injury: an overview of epidemiology, pathophysiology, and medical management. Med Clin 104(2):213–238

Google Scholar 

McCrea MA, Giacino JT, Barber J et al (2021) Functional outcomes over the first year after moderate to severe traumatic brain injury in the prospective, longitudinal TRACK-TBI study. JAMA Neurol 78(8):982–992. https://doi.org/10.1001/jamaneurol.2021.2043

Article  PubMed  PubMed Central  Google Scholar 

Bonow RH, Barber J, Temkin NR, Videtta W, Rondina C, Petroni G, Lujan S, Alanis V, La Fuente G, Lavadenz A, Merida R, Jibaja M, Gonzáles L, Falcao A, Romero R, Dikmen S, Pridgeon J, Chesnut RM, Global Neurotrauma Research Group (2018) The outcome of severe traumatic brain injury in Latin America. World Neurosurg 111:e82–e90. https://doi.org/10.1016/j.wneu.2017.11.171

Sav A, Rotondo F, Syro LV, Serna CA, Kovacs K (2019) Pituitary pathology in traumatic brain injury: a review. Pituitary 22:201–211

Article  PubMed  Google Scholar 

Glynn N, Agha A (2019) The frequency and the diagnosis of pituitary dysfunction after traumatic brain injury. Pituitary 15(22):249–260

Article  Google Scholar 

Mele C, Pingue V, Caputo M, Zavattaro M, Pagano L, Prodam F, Nardone A, Aimaretti G, Marzullo P (2021) Neuroinflammation and hypothalamo-pituitary dysfunction: focus of traumatic brain injury. Int J Mol Sci 22(5):2686

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kałas M, Miksiewicz M, Kowalke A, Siemiński M (2023) Post-Traumatic Hypopituitarism: A Neglected Consequence of Traumatic Brain Injury. Neuroendocrinology 113(6):579–588

Article  PubMed  Google Scholar 

Temizkan S, Kelestimur F (2019) A clinical and pathophysiological approach to traumatic brain injury-induced pituitary dysfunction. Pituitary 22:220–228

Article  PubMed  Google Scholar 

Klose M, Feldt-Rasmussen U (2018) Chronic endocrine consequences of traumatic brain injury—what is the evidence? Nat Rev Endocrinol 14(1):57–62

Article  PubMed  CAS  Google Scholar 

Molaie AM, Maguire J (2018) Neuroendocrine abnormalities following traumatic brain injury: an important contributor to neuropsychiatric sequelae. Front Endocrinol 9:329644

Article  Google Scholar 

Pavlovic D, Pekic S, Stojanovic M, Popovic V (2019) Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae. Pituitary 22:270–282

Article  PubMed  Google Scholar 

Caputo M, Mele C, Prodam F, Marzullo P, Aimaretti G (2019) Clinical picture and the treatment of TBI-induced hypopituitarism. Pituitary 22:261–269

Article  PubMed  Google Scholar 

Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, McKenzie JE (2021) PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. BMJ 372:n160. https://doi.org/10.1136/bmj.n160

Peterson J, Welch V, Losos M, Tugwell P (2011) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Ottawa Hospital Research Institute, Ottawa

Balduzzi S, Rücker G, Schwarzer G (2019) How to perform a meta-analysis with R: a practical tutorial. BMJ Ment Health 22(4):153–160

Google Scholar 

Agha A, Phillips J, O’Kelly P, Tormey W, Thompson CJ (2005) The natural history of post-traumatic hypopituitarism: implications for assessment and treatment. Am J Med 118(12):1416-e1

Article  PubMed  Google Scholar 

Agha A, Rogers B, Sherlock M, O’Kelly P, Tormey W, Phillips J, Thompson CJ (2004) Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab 89(10):4929–36

Article  PubMed  CAS  Google Scholar 

Aimaretti G, Ambrosio MR, Di Somma C, Fusco A, Cannavò S, Gasperi M, Scaroni C, De Marinis L, Benvenga S, Uberti EC, Lombardi G (2004) Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: screening study at 3 months after the brain injury. Clin Endocrinol 61(3):320–6

Article  CAS  Google Scholar 

Aimaretti G, Ambrosio MR, Di Somma C, Gasperi M, Cannavo S, Scaroni C, Fusco A, Del Monte P, De Menis E, Faustini-Fustini M, Grimaldi F (2005) Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. J Clin Endocrinol Metab 90(11):6085–92

Article  PubMed  CAS  Google Scholar 

Alavi SA, Tan CL, Menon DK, Simpson HL, Hutchinson PJ (2016) Incidence of pituitary dysfunction following traumatic brain injury: A prospective study from a regional neurosurgical centre. Br J Neurosurg 30(3):302–6

Article  PubMed  Google Scholar 

Bavisetty S, Bavisetty S, McArthur DL, Dusick JR, Wang C, Cohan P, Boscardin WJ, Swerdloff R, Levin H, Chang DJ, Muizelaar JP (2008) Chronic hypopituitarism after traumatic brain injury: risk assessment and relationship to outcome. Neurosurgery 62(5):1080–94

PubMed  Google Scholar 

Bensalah M, Donaldson M, Labassen M, Cherfi L, Nebbal M, Haffaf EM, Abdennebi B, Guenane K, Kemali Z, Ould KS (2020) Prevalence of hypopituitarism and quality of life in survivors of post-traumatic brain injury. Endocrinol Diabetes Metab 3(3):e00146

Article  PubMed  PubMed Central  CAS  Google Scholar 

Berg C, Oeffner A, Schumm-Draeger PM, Badorrek F, Brabant G, Gerbert B, Bornstein S, Zimmermann A, Weber M, Broecker-Preuss M, Mann K (2010) Prevalence of anterior pituitary dysfunction in patients following traumatic brain injury in a German multi-centre screening program. Exp Clin Endocrinol Diabetes 118(02):139–44

Article  PubMed  CAS  Google Scholar 

Bondanelli M, De Marinis L, Ambrosio MR, Monesi M, Valle D, Zatelli MC, Fusco A, Bianchi A, Farneti M, Degli EC (2004) Occurrence of pituitary dysfunction following traumatic brain injury. J Neurotrauma 21(6):685–96

Article  PubMed  Google Scholar 

Bushnik T, Englander J, Katznelson L (2007) Fatigue after TBI: association with neuroendocrine abnormalities. Brain Inj 21(6):559–66

Article  PubMed  Google Scholar 

Choudhary A, Sobti S, Dev N, Kulshreshtha B, Sharma R, Kaushik K, Kumar A (2023) Dilemmas in the management of acute TBI: a prospective observational study of anterior pituitary dysfunction and its correlation with outcome. Indian J Neurotrauma 21. https://doi.org/10.1055/s-0043-1769802

Ciarlone SL, Statz JK, Goodrich JA, Norris JN, Goforth CW, Ahlers ST, Tschiffely AE (2020) Neuroendocrine function and associated mental health outcomes following mild traumatic brain injury in OEF-deployed service members. J Neurosci Res 98(6):1174–87

Article  PubMed  CAS  Google Scholar 

Eggertsdóttir Claessen LÓ, Kristjánsdóttir H, Jónsdóttir MK, Lund SH, Unnsteinsdóttir Kristensen I, Sigurjónsdóttir HÁ (2024) Pituitary dysfunction following mild traumatic brain injury in female athletes. Endocr Connect 13(2):e230363. https://doi.org/10.1530/EC-23-0363

Cuesta M, Hannon MJ, Crowley RK, Behan LA, Tormey W, Rawluk D, Delargy M, Agha A, Thompson CJ (2016) Symptoms of gonadal dysfunction are more predictive of hypopituitarism than nonspecific symptoms in screening for pituitary dysfunction following moderate or severe traumatic brain injury. Clin Endocrinol 84(1):92–8

Article  CAS  Google Scholar 

Daloglu OO, Unal MC, Kemaloglu CA, Bolatturk OF, Ozyazgan I, Tanriverdi F, Coruh AL, Kelestimur F (2024) Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures. J Endocrinol Invest 19:1–9

Google Scholar 

Dimopoulou I, Tsagarakis S, Theodorakopoulou M, Douka E, Zervou M, Kouyialis AT, Thalassinos N, Roussos C (2004) Endocrine abnormalities in critical care patients with moderate-to-severe head trauma: incidence, pattern and predisposing factors. Intensive Care Med 30:1051–7

Article  PubMed  Google Scholar 

Frendl I, Katko M, Galgoczi E, Boda J, Zsiros N, Nemeti Z, Bereczky Z, Hudak R, Kappelmayer J, Erdei A, Turchanyi B (2017) Plasminogen activator inhibitor type 1: a possible novel biomarker of late pituitary dysfunction after mild traumatic brain injury. J Neurotrauma 34(23):3238–44

Article  PubMed  Google Scholar 

Gupta P, Mittal RS, Sharma A, Kumar V (2021) Endocrine Dysfunction in Traumatic Subarachnoid Hemorrhage: A Prospective Study. Indian J Neurosurg 10(03):220–9

Article  Google Scholar 

Herrmann BL, Rehder J, Kahlke S, Wiedemayer H, Doerfler A, Ischebeck W, Laumer R, Forsting M, Stolke D, Mann K (2006) Hypopituitarism following severe traumatic brain injury. Exp Clin Endocrinol Diabetes 114(06):316–21

Article  PubMed  CAS  Google Scholar 

High WM Jr, Briones-Galang M, Clark JA, Gilkison C, Mossberg KA, Zgaljardic DJ, Masel BE, Urban RJ (2010) Effect of growth hormone replacement therapy on cognition after traumatic brain injury. J Neurotrauma 27(9):1565–75

Article  PubMed  PubMed Central  Google Scholar 

Jeong JH, Kim YZ, Cho YW, Kim JS (2010) Negative effect of hypopituitarism following brain trauma in patients with diffuse axonal injury. J Neurosurg 113(3):532–8

Article  PubMed  Google Scholar 

Kleindienst A, Brabant G, Bock C, Maser-Gluth C, Buchfelder M (2009) Neuroendocrine function following traumatic brain injury and subsequent intensive care treatment: a prospective longitudinal evaluation. J Neurotrauma 26(9):1435–46