Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10:1–11.

Google Scholar 

Moheb M, Iraji A, Dastyafteh N, Khalili Ghomi M, Noori M, Mojtabavi S, et al. Synthesis and bioactivities evaluation of quinazolin-4 (3 H)-one derivatives as α-glucosidase inhibitors. BMC Chem. 2022;16:97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

DiNicolantonio JJ, Bhutani J, O’Keefe JH. Acarbose: safe and effective for lowering postprandial hyperglycaemia and improving cardiovascular outcomes. Open heart. 2015;2:e000327.

Article  PubMed  PubMed Central  Google Scholar 

Avery MA, Mizuno CS, Chittiboyina AG, Kurtz TW, Pershadsingh HA. Type 2 diabetes and oral antihyperglycemic drugs. Curr Med Chem. 2008;15:61–74.

Article  PubMed  Google Scholar 

Tundis R, Loizzo MR, Menichini F. Natural products as α-amylase and α-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update. Mini-Rev Med Chem. 2010;10:315–31.

Article  CAS  PubMed  Google Scholar 

Lebovitz HE. A new oral therapy for diabetes management: alpha-glucosidase inhibition with acarbose. Clinical diabetes. 1995;13:99–104.

Google Scholar 

Noori M, Davoodi A, Iraji A, Dastyafteh N, Khalili M, Asadi M, et al. Design, synthesis, and in silico studies of quinoline-based-benzo [d] imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors. Sci Rep. 2022;12:14019.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adib M, Peytam F, Rahmanian-Jazi M, Mohammadi-Khanaposhtani M, Mahernia S, Bijanzadeh HR, et al. Design, synthesis and in vitro α-glucosidase inhibition of novel coumarin-pyridines as potent antidiabetic agents. New J Chem. 2018;42:17268–78.

Article  CAS  Google Scholar 

Kazempour-Dizaji M, Mojtabavi S, Sadri A, Ghanbarpour A, Faramarzi MA, Navidpour L. Arylureidoaurones: Synthesis, in vitro α-glucosidase, and α-amylase inhibition activity. Bioorg Chem. 2023;139:106709.

Article  CAS  PubMed  Google Scholar 

Figueiredo-González M, Grosso C, Valentão P, Andrade PB. α-Glucosidase and α-amylase inhibitors from Myrcia spp.: a stronger alternative to acarbose? J Pharm Biomed Anal. 2016;118:322–7.

Article  PubMed  Google Scholar 

Kwon YI, Apostolidis E, Shetty K. Inhibitory potential of wine and tea against α‐amylase and α‐glucosidase for management of hyperglycemia linked to type 2 diabetes. J Food Biochem. 2008;32:15–31.

Article  CAS  Google Scholar 

Spasov AA, Yozhitsa IN, Bugaeva LI, Anisimova VA. Benzimidazole derivatives: Spectrum of pharmacological activity and toxicological properties (a review). Pharm Chem J. 1999;33:232–43.

Article  CAS  Google Scholar 

Keri RS, Hiremathad A, Budagumpi S, Nagaraja BM. Comprehensive review in current developments of benzimidazole‐based medicinal chemistry. Chem Biol Drug Des. 2015;86:19–65.

Article  PubMed  Google Scholar 

Wu K, Peng X, Chen M, Li Y, Tang G, Peng J, et al. Recent progress of research on anti‐tumor agents using benzimidazole as the structure unit. Chem Biol Drug Des. 2022;99:736–57.

Article  CAS  PubMed  Google Scholar 

Venugopal S, Kaur B, Verma A, Wadhwa P, Magan M, Hudda S, et al. Recent advances of benzimidazole as anticancer agents. Chem Biol Drug Des. 2023;102:357–76.

Article  CAS  PubMed  Google Scholar 

Flores-Carrillo P, Velázquez-López JM, Aguayo-Ortiz R, Hernández-Campos A, Trejo-Soto PJ, Yépez-Mulia L, et al. Synthesis, antiprotozoal activity, and chemoinformatic analysis of 2-(methylthio)-1H-benzimidazole-5-carboxamide derivatives: Identification of new selective giardicidal and trichomonicidal compounds. Eur J Med Chem. 2017;137:211–20.

Article  CAS  PubMed  Google Scholar 

Ibraheem F, Ahmad M, Ashfaq UA, Aslam S, Ali Khan Z, Sultan S. Synthesis, molecular docking and anti-diabetic studies of novel benzimidazole-pyrazoline hybrid molecules. Pak J Pharm Sci. 2020;23:847–54.

Google Scholar 

Patagar DN, Batakurki SR, Kusanur R, Patra SM, Saravanakumar S, Ghate M. Synthesis, antioxidant and anti-diabetic potential of novel benzimidazole substituted coumarin-3-carboxamides. J Mol Struct. 2023;1274:134589.

Article  CAS  Google Scholar 

Spasov AA, Vassiliev PM, Anisimova VA, Zhukovskaya ON Antidiabetogenic features of benzimidazoles. Chemistry and Applications of Benzimidazole and its Derivatives: IntechOpen. 2019;73–87.

Taha M, Rahim F, Adalath B, Imran S, Khan KM, Uddin N, et al. Synthesis of benzimidazole derivatives and their antiglycation, antioxidant, antiurease and molecular docking study. Arab J Chem. 2024;17:105700.

Article  CAS  Google Scholar 

Karimian S, Shekouhy M, Pirhadi S, Iraji A, Attarroshan M, Edraki N, et al. Synthesis and biological evaluation of benzimidazoles/1, 3, 5-triazine-2, 4-diamine hybrid compounds: a new class of multifunctional alzheimer targeting agents. New J Chem. 2022;46:15567–84.

Article  CAS  Google Scholar 

Faydalı N, Arpacı ÖT. Benzimidazole and Benzoxazole Derivatives Against Alzheimer’s Disease. Chem Biodivers. 2024;21:e202400123.

Article  PubMed  Google Scholar 

Machhi J, Prajapati N, Kanhed AM, Patel K, Giridhar R, Yadav MR. D3 Antagonist and Antipsychotic Potential of Some Novel Benzazepines. J Pharm Sci Pharmacol. 2015;2:123–33.

Article  Google Scholar 

Iqbal H, Yadav P, Verma AK, Mishra D, Vamadevan B, Singh D, et al. Anti-inflammatory, anti-oxidant and cardio-protective properties of novel fluorophenyl benzimidazole in L-NAME-induced hypertensive rats. Eur J Pharmacol. 2022;929:175132.

Article  CAS  PubMed  Google Scholar 

Bhandari SV, Nagras OG, Kuthe PV, Sarkate AP, Waghamare KS, Pansare DN, et al. Design, synthesis, molecular docking and antioxidant evaluation of benzimidazole-1, 3, 4 oxadiazole derivatives. J Mol Struct. 2023;1276:134747.

Article  CAS  Google Scholar 

Singh N, Pandurangan A, Rana K, Anand P, Ahamad A, Tiwari AK. Benzimidazole: A short review of their antimicrobial activities. Int Current Pharm J. 2012;1:119–27.

Article  CAS  Google Scholar 

Mao L, Wang S, Qu Y, Wang H, Zhao Y, Zhu C, et al. Design, synthesis, and anti-respiratory syncytial virus potential of novel 3-(1, 2, 3-triazol-1-yl) furoxazine-fused benzimidazole derivatives. Eur J Med Chem. 2023;261:115799.

Article  CAS  PubMed  Google Scholar 

Asgari MS, Mohammadi-Khanaposhtani M, Kiani M, Ranjbar PR, Zabihi E, Pourbagher R, et al. Biscoumarin-1, 2, 3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro α-glucosidase inhibition, kinetic, and docking studies. Bioorg Chem. 2019;92:103206.

Article  CAS  PubMed  Google Scholar 

Kumar L, Lal K, Yadav P, Kumar A, Paul AK. Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1, 2, 3-triazole hybrids. J Mol Struct. 2020;1216:128253.

Article  CAS  Google Scholar 

Jabeen F, Shehzadi SA, Fatmi MQ, Shaheen S, Iqbal L, Afza N, et al. Synthesis, in vitro and computational studies of 1, 4-disubstituted 1, 2, 3-triazoles as potential α-glucosidase inhibitors. Bioorg Med Chem Lett. 2016;26:1029–38.

Article  CAS  PubMed  Google Scholar 

Avula SK, Khan A, Halim SA, Al-Abri Z, Anwar MU, Al-Rawahi A, et al. Synthesis of novel (R)-4-fluorophenyl-1H-1, 2, 3-triazoles: A new class of α-glucosidase inhibitors. Bioorg Chem. 2019;91:103182.

Article  PubMed  Google Scholar 

Aroua LM, Almuhaylan HR, Alminderej FM, Messaoudi S, Chigurupati S, Al-Mahmoud S, et al. A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity. Bioorg Chem. 2021;114:105073.

Article  CAS  PubMed  Google Scholar 

Shayegan N, Iraji A, Bakhshi N, Moazzam A, Faramarzi MA, Mojtabavi S, et al. Design, synthesis, and in silico studies of benzimidazole bearing phenoxyacetamide derivatives as α-glucosidase and α-amylase inhibitors. J Mol Struct. 2022;1268:133650.

Article  CAS  Google Scholar 

Azizian H, Pedrood K, Moazzam A, Valizadeh Y, Khavaninzadeh K, Zamani A, et al. Docking study, molecular dynamic, synthesis, anti-α-glucosidase assessment, and ADMET prediction of new benzimidazole-Schiff base derivatives. Sci Rep. 2022;12:14870.

Article  CAS  PubMed  PubMed Central  Google Scholar