Objective Diabetes mellitus poses significant challenges to individuals' well-being, affecting various aspects of their lives beyond the physical symptoms of the disease. Understanding the multidimensional aspects of QoL among diabetic patients is crucial for providing holistic healthcare interventions and improving overall health outcomes. The study aims to evaluate the quality of life of Type II Diabetes Mellitus patients. Research Design and Methods Descriptive cross-sectional study was conducted among 334 diagnosed cases of Type 2 Diabetes Mellitus for more than or equal to 6 months attending the outpatient department of UCMS-TH. Non-probability purposive sampling technique was used to select samples for the study. The WHOQOL-BREF questionnaire was used to measure QoL. Data were analyzed with descriptive statistics (frequency, percentage, mean, standard deviation) and inferential statistics (t-tests or one way ANOVA) to explore associations between QoL domains and sociodemographic characteristics. Results More than half (56.6%) of the respondents were between the age group of 41-60 years with mean age of 58.42. Highest mean score ± SD was found in social domain (60.77 ± 13.83) followed by environmental domain (56.05 ± 10.38) and psychological domain (55.67 ±8.44) with least mean domain score in physical domain (49.99 ± 14.53). The results show that diabetic patients, particularly women and those with comorbid conditions, report lower quality of life in all domains. Additionally, no significant association was found between having a family history of diabetes and quality of life. There was high positive correlation between physical and environmental domain of quality of life (r = 0.70, p < 0.001). Conclusion Comprehensive management strategies focusing on all dimensions of health is necessary to improve the quality of life of patients with Diabetes Mellitus.

The authors have declared no competing interest.

The author(s) received no specific funding for this work.

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

This study has been approved by Institutional Review Committee of Universal College of Medical Sciences, Bhairahawa (UCMS/IRC/030/23)

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Yes

All relevant data are within the manuscript and its Supporting Information files.