Herein, we have reported a mild, efficient, and strategic rapid approach for the preparation of CF3-phenanthridones through a cross-conjugated vinylogous [4+2] benzannulation of easily accessible 4-methyl-3-trifluoroacetylquinolones and nitro-olefins. The present transformation is superior to previous approaches for CF3-phenanthridones, which proceeds exclusively with the assistance of a simple base, eliminating the necessity of any transition metal catalyst and oxidant. The strong electron-withdrawing nature of the CF3-group present in quinolone moiety promotes the formation of reactive cross-conjugated vinylogous enolate.

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