Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424. https://doi.org/10.3322/caac.21492
Nagtegaal ID, Arends MJ, Salto-Tellez M (2019) Colorectal Adenocarcinoma. WHO classification of tumours. 5th ed. Digestive system tumour. Lyon: International Agency for Research on Cancer. p.177–187
Rawla P, Sunkara T, Barsouk A (2019) Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol 14(2):89–103. https://doi.org/10.5114/pg.2018.81072
Hamilton SR, Sekine S (2019) Conventional colorectal adenoma. WHO classification of tumours. 5th ed. Digestive system tumour. Lyon: International Agency for Research on Cancer. p.170–173
Pai RK (Rish), Mӓkinen MJ, Rosty C (2019) Colorectal serrated lesions, and polyps. WHO classification of tumours. 5th ed. Digestive system tumour. Lyon: International Agency for Research on Cancer. p.163–169
Odze RD, Harpaz N (2019) Inflammatory bowel disease-associated dysplasia of the colorectum. WHO classification of tumours. 5th ed. Digestive system tumour. Lyon: International Agency for Research on Cancer. p.174–176
Kudryavtseva AV, Lipatova AV, Zaretsky AR, Moskalev AA, Fedorova MS, Rasskazova AS, Shibukhova GA, Snezhkina AV, Kaprin AD, Alekseev BY, Dmitriev AA (2016) Important molecular genetic markers of colorectal cancer. Oncotarget 7(33):53959. https://doi.org/10.18632/oncotarget.9796
Article PubMed PubMed Central Google Scholar
Monsalve FA, Pyarasani RD, Delgado-Lopez F, Moore-Carrasco R (2013) Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases. Mediators Inflamm 2013:549627. https://doi.org/10.1155/2013/549627
Article CAS PubMed PubMed Central Google Scholar
Torra IP, Chinetti G, Duval C, Fruchart JC, Staels B (2001) Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. Curr Opin Lipidol 12(3):245–254. https://doi.org/10.1097/00041433-200106000-00002
Article CAS PubMed Google Scholar
Tyagi S, Gupta P, Saini AS, Kaushal C, Sharma S (2011) The peroxisome proliferator-activated receptor: a family of nuclear receptors role in various diseases. J Adv Pharm Technol Res 2(4):236. https://doi.org/10.4103/2231-4040.90879
Article CAS PubMed PubMed Central Google Scholar
Larsen TM, Toubro S, Astrup A (2003) PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? Int J Obes 27(2):147–161. https://doi.org/10.1038/sj.ijo.802223
Jakubowska K, Kisielewski W, Kańczuga-Koda L, Koda M, Famulski W (2017) Stromal and intraepithelial tumor-infiltrating lymphocytes in colorectal carcinoma. Oncol Lett 14(6):6421–6432. https://doi.org/10.3892/ol.2017.7013
Article CAS PubMed PubMed Central Google Scholar
Iseki Y, Shibutani M, Maeda K, Nagahara H, Fukuoka T, Matsutani S, Kashiwagi S, Tanaka H, Hirakawa K, Ohira M (2018) A new method for evaluating tumor-infiltrating lymphocytes (TILs) in colorectal cancer using hematoxylin and eosin (HE)-stained tumor sections. PLoS ONE 13(4):e0192744. https://doi.org/10.1371/journal.pone.0192744
Article CAS PubMed PubMed Central Google Scholar
Graham DM, Appelman HD (1990) Crohn’s-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator. Mod Pathol 3(3):332–335
Ueno H, Hashiguchi Y, Shimazaki H, Shinto E, Kajiwara Y, Nakanishi K, Kato K, Maekawa K, Miyai K, Nakamura T, Yamamoto J, Hase K (2013) Objective criteria for Crohn-like lymphoid reaction in colorectal cancer. Am J Clin Pathol 139(4):434–441. https://doi.org/10.1309/AJCPWHUEFTGBWKE4
Article CAS PubMed Google Scholar
Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK, Milburn MV (1998) Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 395(6698):137–143. https://doi.org/10.1038/25931
Article CAS PubMed Google Scholar
Elrod HA, Sun SY (2008) PPAR gamma and apoptosis in cancer. PPAR Res 2008:704165. https://doi.org/10.1155/2008/704165
Article CAS PubMed PubMed Central Google Scholar
Willson TM, Brown PJ, Sternbach DD, Henke BR (2000) The PPARs: from orphan receptors to drug discovery. J Med Chem 43:527–550. https://doi.org/10.1021/jm990554g
Article CAS PubMed Google Scholar
Sabatino L, Fucci A, Pancione M, Colantuoni V (2012) PPARG epigenetic deregulation and its role in colorectal tumorigenesis. PPAR Res 2012:687492. https://doi.org/10.1155/2012/687492
Article CAS PubMed PubMed Central Google Scholar
Ogino S, Shima K, Baba Y, Nosho K, Irahara N, Kure S et al (2009) Colorectal cancer expression of peroxisome proliferator-activated receptor γ (PPARG, PPARγ) is associated with good prognosis. Gastroenterology 136(4):1242–1250. https://doi.org/10.1053/j.gastro.2008.12.048
Article CAS PubMed Google Scholar
Saez E, Tontonoz P, Nelson MC et al (1998) Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat Med 4:1058–1061. https://doi.org/10.1038/2042
Article CAS PubMed Google Scholar
Yun SH, Roh MS, Jeong JS, Park JI (2018) Peroxisome proliferator-activated receptor γ coactivator-1α is a predictor of lymph node metastasis and poor prognosis in human colorectal cancer. Ann Diagn Pathol 33:11–16. https://doi.org/10.1016/j.anndiagpath.2017.11.007
Shimada T, Kojima K, Yoshiura K, Hiraishi H, Terano A (2002) Characteristics of the peroxisome proliferator-activated receptor γ (PPARγ) ligand-induced apoptosis in colon cancer cells. Gut 50(5):658–664. https://doi.org/10.1136/gut.50.5.658
Article CAS PubMed PubMed Central Google Scholar
Jackson L, Wahli W, Michalik L, Watson SA, Morris T, Anderton K et al (2003) Potential role for peroxisome proliferator-activated receptor (PPAR) in preventing colon cancer. Gut 52(9):1317–1322. https://doi.org/10.1136/gut.52.9.1317
Article CAS PubMed PubMed Central Google Scholar
Theocharis S, Giaginis C, Parasi A, Margeli A, Kakisis J, Agapitos E, Kouraklis G (2007) Expression of peroxisome proliferator-activated receptor-γ in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients’ survival. Dig Dis Sci 52(9):2305–2311. https://doi.org/10.1007/s10620-007-9794-4
Article CAS PubMed Google Scholar
Gustafsson A, Hansson E, Kressner U et al (2007) EP1-4 subtype, COX and PPAR gamma receptor expression in colorectal cancer in prediction of disease-specific mortality. Int J Cancer 121:232–240. https://doi.org/10.1002/ijc.22582
Article CAS PubMed Google Scholar
Yun SH, Han SH, Park JI (2018) Peroxisome proliferator-activated receptor γ and PGC-1α in cancer: dual actions as tumor promoter and suppressor. PPAR Res 21(2018):6727421. https://doi.org/10.1155/2018/6727421
Tsukahara T, Haniu H (2012) Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells. Biochem Biophys Res Commun 424(3):524–529. https://doi.org/10.1016/j.bbrc.2012.06.149
Article CAS PubMed Google Scholar
Aires V, Brassart B, Carlier A, Scagliarini A, Mandard S, Limagne E, Solary E, Martiny L, Tarpin M, Delmas D (2014) A role for peroxisome proliferator-activated receptor γ in resveratrol-induced colon cancer cell apoptosis. Mol Nutr Food Res 58(9):1785–1794. https://doi.org/10.1002/mnfr.201300962
Article CAS PubMed Google Scholar
Kwon AK, Yun J, Oh SY, Seo BG, Lee S, Lee JH, Kim SH, Choi HJ, Roh MS, Kim HJ (2016) Clinical significance of peroxisome proliferator-activated receptor γ and TRAP220 in patients with operable colorectal cancer. Cancer Res Treat 48(1):198–207. https://doi.org/10.4143/crt.2015.024
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